1. Cerebrospinal fluid beta-2-microglobulin in multiple sclerosis and AIDS dementia complex
- Author
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A Ponticiello, A. Maiorino, G A Buscaino, Pietro Biagio Carrieri, Oreste Perrella, A Indaco, Liberti A, Carrieri, Pb, Indaco, A, Maiorino, A, Buscaino, Ga, Ponticiello, Antonio, Liberti, A, and Perrella, O.
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,AIDS Dementia Complex ,Multiple Sclerosis ,cerebrospinal fluid, Nervous System Disease ,cerebrospinal fluid ,Cerebrospinal fluid ,cerebrospinal fluid, beta 2-Microglobulin ,AIDS dementia complex ,HIV Seropositivity ,cerebrospinal fluid, Adult, Female, HIV Seropositivity, Humans, Male, Multiple Sclerosi ,medicine ,Humans ,business.industry ,Beta-2 microglobulin ,Multiple sclerosis ,General Medicine ,Serum concentration ,medicine.disease ,Hiv seropositivity ,body regions ,Neurology ,Female ,Neurology (clinical) ,Nervous System Diseases ,business ,beta 2-Microglobulin - Abstract
Cerebrospinal fluid (CSF) and serum concentrations of beta-2-microglobulin (beta-2-m) were evaluated in 19 patients with clinically definite multiple sclerosis (MS), in 21 with AIDS dementia complex (ADC), and in 20 subjects with other neurological diseases (OND). CSF beta-2-m and CSF/serum beta-2-m ratio were significantly higher in the patients with ADC than in the MS and OND patients. The CSF and serum levels of beta-2-m in MS patients were not significantly different from those of OND patients. These findings indicate that CSF beta-2-m and CSF/serum ratio may be a useful marker in the diagnosis of ADC. In MS patients the beta-2-m CSF determinations are of no value.
- Published
- 1992