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1. Multiorgan dysfunction and disseminated intravascular coagulation in children receiving lamotrigine and valproic acid.

Author

Chattergoon DS, McGuigan MA, Koren G, Hwang P, and Ito S

Subjects
Child, Child, Preschool, Drug Interactions, Drug Therapy, Combination, Female, Humans, Lamotrigine, Male, Anticonvulsants adverse effects, Disseminated Intravascular Coagulation chemically induced, Multiple Organ Failure chemically induced, Triazines adverse effects, Valproic Acid adverse effects
Abstract

Two children developed multiorgan dysfunction with disseminated intravascular coagulation 9 days after lamotrigine was added to their antiepileptic therapy, which included valproic acid. During the episodes, rhabdomyolysis was detected in one of them, while being seizure-free, suggesting that this adverse reaction may involve muscular tissue.

Published
1997
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