1. Neural correlates of naming errors across different neurodegenerative diseases: An FDG-PET study
- Author
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Alberto Pupi, Luca Presotto, Sandro Iannaccone, Stefano F. Cappa, Valentina Berti, Valentina Esposito, Cristina Polito, Massimo Filippi, Eleonora Catricalà, Sandro Sorbi, Celeste Gasparri, Giuseppe Magnani, Arianna Sala, Daniela Perani, Francesca Conca, Catricalà, Eleonora, Polito, Cristina, Presotto, Luca, Esposito, Valentina, Sala, Arianna, Conca, Francesca, Gasparri, Celeste, Berti, Valentina, Filippi, Massimo, Pupi, Alberto, Sorbi, Sandro, Iannaccone, Sandro, Magnani, Giuseppe, Cappa, Stefano F., Perani, Daniela, Catricala, E, Polito, C, Presotto, L, Esposito, V, Sala, A, Conca, F, Gasparri, C, Berti, V, Filippi, M, Pupi, A, Sorbi, S, Iannaccone, S, Magnani, G, Cappa, S, and Perani, D
- Subjects
Male ,medicine.medical_specialty ,Audiology ,Statistical parametric mapping ,050105 experimental psychology ,Lateralization of brain function ,Temporal lobe ,neuroscience ,Primary progressive aphasia ,03 medical and health sciences ,0302 clinical medicine ,Alzheimer Disease ,Fluorodeoxyglucose F18 ,Aphasia ,medicine ,Connectome ,Humans ,Speech ,0501 psychology and cognitive sciences ,Aged ,Language ,Retrospective Studies ,Aged, 80 and over ,Neural correlates of consciousness ,Fusiform gyrus ,business.industry ,05 social sciences ,Neurodegenerative Diseases ,medicine.disease ,Temporal Lobe ,image processing ,Semantics ,PET ,Aphasia, Primary Progressive ,Pattern Recognition, Visual ,Frontotemporal Dementia ,Positron-Emission Tomography ,Dementia ,Female ,Neurology (clinical) ,Occipital Lobe ,Supranuclear Palsy, Progressive ,medicine.symptom ,Occipital lobe ,business ,030217 neurology & neurosurgery - Abstract
ObjectiveTo investigate the types of errors produced in a picture naming task by patients with neurodegenerative dementia due to different etiologies and their neural correlates.MethodsThe same standardized picture naming test was administered to a consecutive sample of patients (n = 148) who had been studied with [18F] FDG-PET. The errors were analyzed in 3 categories (visual, semantic, and phonologic). The PET data were analyzed using an optimized single-subject procedure, and the statistical parametric mapping multiple regression design was used to explore the correlation between each type of error and brain hypometabolism in the whole group. Metabolic connectivity analyses were run at the group level on 7 left hemisphere cortical areas corresponding to an a priori defined naming network.ResultsSemantic errors were predominant in most patients, independent of clinical diagnosis. In the whole group analysis, visual errors correlated with hypometabolism in the right inferior occipital lobe and in the left middle occipital lobe. Semantic errors correlated with hypometabolism in the left fusiform gyrus, the inferior and middle temporal gyri, and the temporal pole. Phonologic errors were associated with hypometabolism in the left superior and middle temporal gyri. Both positive (occipital–posterior fusiform) and negative (anterior fusiform gyrus and the superior anterior temporal lobe) connectivity changes were associated with semantic errors.ConclusionsNaming errors reflect the dysfunction of separate stages of the naming process and are specific markers for different patterns of brain involvement. These correlations are not limited to primary progressive aphasia but extend to other neurodegenerative dementias.
- Published
- 2020