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34 results on '"Cross, J."'

1. Hypothalamic Hamartomas: Evolving Understanding and Management

Author

Cohen, Nathan T., Cross, J. Helen, Arzimanoglou, Alexis, Berkovic, Samuel F., Kerrigan, John F., Miller, Ilene Penn, Webster, Erica, Soeby, Lisa, Cukiert, Arthur, Hesdorffer, Dale K., Kroner, Barbara L., Saper, Clifford B., Schulze-Bonhage, Andreas, Gaillard, William D., Berkovic, Samuel Frank, Berl, Madison, Biesecker, Leslie G., Boerwinkle, Varina L., Brandt, Carrin, Bulteau, Christine, Chen, Xi, Cohen, Nathan T., Cross, J. Helen, Cukiert, Arthur, Curry, Daniel J., Dacks, Penny, De Palma, Luca, Ferrand-Sorbets, Sarah, Fulton, John B., Gaillard, William Davis, Geiger, Maximilian J., Grinspan, Zachary, Gupta, Ajay, Hamdi, Hussein M., Hauptman, Jason, Hildebrand, Michael S., Jacobs, Julia, Kerrigan, John (Jack) F., Klotz, Kerstin Alexandra, Koh, Sookyong, Liang, HoLan, Mathern, Gary W., Mbwana, Juma, Miller, Ian, Miller, Ilene Penn, Not, Emma, Oatman, Oliver J., Oluigbo, Chima, Packer, Roger J., Ragheb, John, Régis, Jean, Rekate, Harold, Rizk, Tamer, Rosenfeld, Jeffrey V., Roth, Christian L., Salpekar, Jay A., Saper, Clifford B., Schulze-Bonhage, Andreas, Shirozu, Hiroshi, Soeby, Lisa, Tatsi, Christina, Theodore, William H., Vezina, Gilbert, Webster, Erica, West, Peter J., Yang, Zhiquan, and Yuen, Kevin C. J.

Published
2021
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3. Cardiac phenotype in ATP1A3-related syndromes: A multicenter cohort study

Author

Balestrini, Simona, Mikati, Mohamad A., Álvarez-García-Rovés, Reyes, Carboni, Michael, Hunanyan, Arsen S., Kherallah, Bassil, McLean, Melissa, Prange, Lyndsey, De Grandis, Elisa, Gagliardi, Alessandra, Pisciotta, Livia, Stagnaro, Michela, Veneselli, Edvige, Campistol, Jaume, Fons, Carmen, Pias-Peleteiro, Leticia, Brashear, Allison, Miller, Charlotte, Samões, Raquel, Brankovic, Vesna, Padiath, Quasar S., Potic, Ana, Pilch, Jacek, Vezyroglou, Aikaterini, Bye, Ann M.E., Davis, Andrew M., Ryan, Monique M., Semsarian, Christopher, Hollingsworth, Georgina, Scheffer, Ingrid E., Granata, Tiziana, Nardocci, Nardo, Ragona, Francesca, Arzimanoglou, Alexis, Panagiotakaki, Eleni, Carrilho, Inês, Zucca, Claudio, Novy, Jan, Dzieżyc, Karolina, Parowicz, Marek, Mazurkiewicz-Bełdzińska, Maria, Weckhuysen, Sarah, Pons, Roser, Groppa, Sergiu, Sinden, Daniel S., Pitt, Geoffrey S., Tinker, Andrew, Ashworth, Michael, Michalak, Zuzanna, Thom, Maria, Cross, J. Helen, Vavassori, Rosaria, Kaski, Juan P., and Sisodiya, Sanjay M.

Published
2020
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4. Keeping people with epilepsy safe during the COVID-19 pandemic

Author

French, Jacqueline A., Brodie, Martin J., Caraballo, Roberto, Devinsky, Orrin, Ding, Ding, Jehi, Lara, Jette, Nathalie, Kanner, Andres, Modi, Avani C., Newton, Charles R., Patel, Archana A., Pennell, Page B., Perucca, Emilio, Sander, Josemir W., Scheffer, Ingrid E., Singh, Gagandeep, Williams, Emma, Wilmshurst, Jo, and Cross, J. Helen

Published
2020
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5. Neurologic phenotypes associated with COL4A1/2 mutations: Expanding the spectrum of disease

Author

Zagaglia, Sara, Selch, Christina, Nisevic, Jelena Radic, Mei, Davide, Michalak, Zuzanna, Hernandez-Hernandez, Laura, Krithika, S., Vezyroglou, Katharina, Varadkar, Sophia M., Pepler, Alexander, Biskup, Saskia, Leão, Miguel, Gärtner, Jutta, Merkenschlager, Andreas, Jaksch, Michaela, Møller, Rikke S., Gardella, Elena, Kristiansen, Britta Schlott, Hansen, Lars Kjærsgaard, Vari, Maria Stella, Helbig, Katherine L., Desai, Sonal, Smith-Hicks, Constance L., Hino-Fukuyo, Naomi, Talvik, Tiina, Laugesaar, Rael, Ilves, Pilvi, Õunap, Katrin, Körber, Ingrid, Hartlieb, Till, Kudernatsch, Manfred, Winkler, Peter, Schimmel, Mareike, Hasse, Anette, Knuf, Markus, Heinemeyer, Jan, Makowski, Christine, Ghedia, Sondhya, Subramanian, Gopinath M., Striano, Pasquale, Thomas, Rhys H., Micallef, Caroline, Thom, Maria, Werring, David J., Kluger, Gerhard Josef, Cross, J. Helen, Guerrini, Renzo, Balestrini, Simona, and Sisodiya, Sanjay M.

Published
2018
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6. Fenfluramine Treatment Is Associated With Improvement in Everyday Executive Function in Adults With Lennox-Gastaut Syndrome: Post-Hoc Analysis of Dose Effects From a Phase 3 Trial Rationale (P11-1.001)

Author

Bishop, Kim, primary, Isquith, Peter, additional, Knupp, Kelly, additional, Sullivan, Joseph, additional, Nabbout, Rima, additional, Gil-Nagel, Antonio, additional, Scheffer, Ingrid, additional, Auvin, Stéphane, additional, Cross, J Helen, additional, Guerrini, Renzo, additional, Roth, Robert, additional, Gioia, Gerard, additional, Lothe, Amélie, additional, and Polega, Shikha, additional

Published
2023
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7. European trends in epilepsy surgery

Author

Baud, Maxime O., Perneger, Thomas, Rácz, Attila, Pensel, Max C., Elger, Christian, Rydenhag, Bertil, Malmgren, Kristina, Cross, J. Helen, McKenna, Grainne, Tisdall, Martin, Lamberink, Herm J., Rheims, Sylvain, Ryvlin, Philippe, Isnard, Jean, Mauguière, François, Arzimanoglou, Alexis, Akkol, Serdar, Deniz, Kaancan, Ozkara, Cigdem, Lossius, Morten, Rektor, Ivan, Kälviäinen, Reetta, Vanhatalo, Lotta-Maria, Dimova, Petia, Minkin, Krassimir, Staack, Anke Maren, Steinhoff, Bernhard J., Kalina, Adam, Krsek, Pavel, Marusic, Petr, Jordan, Zsofia, Fabo, Daniel, Carrette, Evelien, Boon, Paul, Rocka, Saulius, Mameniškienė, Rūta, Vulliemoz, Serge, Pittau, Francesca, Braun, Kees P.J., and Seeck, Margitta

Published
2018
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9. Clinical and molecular characterization of KCNT1-related severe early-onset epilepsy

Author

McTague, Amy, Nair, Umesh, Malhotra, Sony, Meyer, Esther, Trump, Natalie, Gazina, Elena V., Papandreou, Apostolos, Ngoh, Adeline, Ackermann, Sally, Ambegaonkar, Gautam, Appleton, Richard, Desurkar, Archana, Eltze, Christin, Kneen, Rachel, Kumar, Ajith V., Lascelles, Karine, Montgomery, Tara, Ramesh, Venkateswaran, Samanta, Rajib, Scott, Richard H., Tan, Jeen, Whitehouse, William, Poduri, Annapurna, Scheffer, Ingrid E., Chong, W.K. “Kling”, Cross, J. Helen, Topf, Maya, Petrou, Steven, and Kurian, Manju A.

Published
2018
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10. Evolving Understanding and Management

Author

Cohen, Nathan T., Cross, J. Helen, Arzimanoglou, Alexis, Berkovic, Samuel F., Kerrigan, John F., Miller, Ilene Penn, Webster, Erica, Soeby, Lisa, Cukiert, Arthur, Hesdorffer, Dale K., Kroner, Barbara L., Saper, Clifford B., Schulze-Bonhage, Andreas, and Gaillard, William D.

Subjects
Epilepsy, Hamartoma, Humans, Review, Comorbidity, Child, Hypothalamic Diseases
Abstract

Hypothalamic hamartomas (HH) are rare, basilar developmental lesions with widespread comorbidities often associated with refractory epilepsy and encephalopathy. Imaging advances allow for early, even prenatal, detection. Genetic studies suggest mutations in GLI3 and other patterning genes are involved in HH pathogenesis. About 50%–80% of children with HH have severe rage and aggression and a majority of patients exhibit externalizing disorders. Behavioral disruption and intellectual disability may predate epilepsy. Neuropsychological, sleep, and endocrine disorders are typical. The purpose of this article is to provide a summary of the current understanding of HH and to highlight opportunities for future research.

Published
2021

11. The Phenotypic Continuum of ATP1A3-Related Disorders

Author

Vezyroglou, Aikaterini, primary, Akilapa, Rhoda, additional, Barwick, Katy, additional, Koene, Saskia, additional, Brownstein, Catherine A., additional, Holder-Espinasse, Muriel, additional, Fry, Andrew E., additional, Németh, Andrea H., additional, Tofaris, George K., additional, Hay, Eleanor, additional, Hughes, Imelda, additional, Mansour, Sahar, additional, Mordekar, Santosh R., additional, Splitt, Miranda, additional, Turnpenny, Peter D., additional, Demetriou, Demetria, additional, Koopmann, Tamara T., additional, Ruivenkamp, Claudia A.L., additional, Agrawal, Pankaj B., additional, Carr, Lucinda, additional, Clowes, Virginia, additional, Ghali, Neeti, additional, Holder, Susan Elizabeth, additional, Radley, Jessica, additional, Male, Alison, additional, Sisodiya, Sanjay M., additional, Kurian, Manju A., additional, Cross, J. Helen, additional, and Balasubramanian, Meena, additional

Published
2022
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14. RHOBTB2 Mutations Expand the Phenotypic Spectrum of Alternating Hemiplegia of Childhood

Author

Zagaglia, Sara, primary, Steel, Dora, additional, Krithika, S., additional, Hernandez-Hernandez, Laura, additional, Custodio, Helena Martins, additional, Gorman, Kathleen M., additional, Vezyroglou, Aikaterini, additional, Møller, Rikke S., additional, King, Mary D., additional, Hammer, Trine Bjørg, additional, Spaull, Robert, additional, Fazeli, Walid, additional, Bartolomaeus, Tobias, additional, Doummar, Diane, additional, Keren, Boris, additional, Mignot, Cyril, additional, Bednarek, Nathalie, additional, Cross, J. Helen, additional, Mallick, Andrew A., additional, Sanchis-Juan, Alba, additional, Basu, Anna, additional, Raymond, F. Lucy, additional, Lynch, Bryan J., additional, Majumdar, Anirban, additional, Stamberger, Hannah, additional, Weckhuysen, Sarah, additional, Sisodiya, Sanjay M., additional, and Kurian, Manju A., additional

Published
2021
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16. Mutations Expand the Phenotypic Spectrum of Alternating Hemiplegia of Childhood.

Author

Zagaglia, Sara, Steel, Dora, Krithika, S., Hernandez-Hernandez, Laura, Custodio, Helena Martins, Gorman, Kathleen M., Vezyroglou, Aikaterini, Møller, Rikke S., King, Mary D., Hammer, Trine Bjørg, Spaull, Robert, Fazeli, Walid, Bartolomaeus, Tobias, Doummar, Diane, Keren, Boris, Mignot, Cyril, Bednarek, Nathalie, Cross, J. Helen, Mallick, Andrew A., and Sanchis-Juan, Alba

Published
2021
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18. Clinical and molecular characterization of KCNT1-related severe early-onset epilepsy

Author

McTague, Amy, primary, Nair, Umesh, additional, Malhotra, Sony, additional, Meyer, Esther, additional, Trump, Natalie, additional, Gazina, Elena V., additional, Papandreou, Apostolos, additional, Ngoh, Adeline, additional, Ackermann, Sally, additional, Ambegaonkar, Gautam, additional, Appleton, Richard, additional, Desurkar, Archana, additional, Eltze, Christin, additional, Kneen, Rachel, additional, Kumar, Ajith V., additional, Lascelles, Karine, additional, Montgomery, Tara, additional, Ramesh, Venkateswaran, additional, Samanta, Rajib, additional, Scott, Richard H., additional, Tan, Jeen, additional, Whitehouse, William, additional, Poduri, Annapurna, additional, Scheffer, Ingrid E., additional, Chong, W.K. “Kling”, additional, Cross, J. Helen, additional, Topf, Maya, additional, Petrou, Steven, additional, and Kurian, Manju A., additional

Published
2017
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19. Practice guideline summary: Sudden unexpected death in epilepsy incidence rates and risk factors

Author

Harden, Cynthia, primary, Tomson, Torbjörn, additional, Gloss, David, additional, Buchhalter, Jeffrey, additional, Cross, J. Helen, additional, Donner, Elizabeth, additional, French, Jacqueline A., additional, Gil-Nagel, Anthony, additional, Hesdorffer, Dale C., additional, Smithson, W. Henry, additional, Spitz, Mark C., additional, Walczak, Thaddeus S., additional, Sander, Josemir W., additional, and Ryvlin, Philippe, additional

Published
2017
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21. TBC1D24genotype–phenotype correlation

Author

Balestrini, Simona, primary, Milh, Mathieu, additional, Castiglioni, Claudia, additional, Lüthy, Kevin, additional, Finelli, Mattea J., additional, Verstreken, Patrik, additional, Cardon, Aaron, additional, Stražišar, Barbara Gnidovec, additional, Holder, J. Lloyd, additional, Lesca, Gaetan, additional, Mancardi, Maria M., additional, Poulat, Anne L., additional, Repetto, Gabriela M., additional, Banka, Siddharth, additional, Bilo, Leonilda, additional, Birkeland, Laura E., additional, Bosch, Friedrich, additional, Brockmann, Knut, additional, Cross, J. Helen, additional, Doummar, Diane, additional, Félix, Temis M., additional, Giuliano, Fabienne, additional, Hori, Mutsuki, additional, Hüning, Irina, additional, Kayserili, Hulia, additional, Kini, Usha, additional, Lees, Melissa M., additional, Meenakshi, Girish, additional, Mewasingh, Leena, additional, Pagnamenta, Alistair T., additional, Peluso, Silvio, additional, Mey, Antje, additional, Rice, Gregory M., additional, Rosenfeld, Jill A., additional, Taylor, Jenny C., additional, Troester, Matthew M., additional, Stanley, Christine M., additional, Ville, Dorothee, additional, Walkiewicz, Magdalena, additional, Falace, Antonio, additional, Fassio, Anna, additional, Lemke, Johannes R., additional, Biskup, Saskia, additional, Tardif, Jessica, additional, Ajeawung, Norbert F., additional, Tolun, Aslihan, additional, Corbett, Mark, additional, Gecz, Jozef, additional, Afawi, Zaid, additional, Howell, Katherine B., additional, Oliver, Karen L., additional, Berkovic, Samuel F., additional, Scheffer, Ingrid E., additional, de Falco, Fabrizio A., additional, Oliver, Peter L., additional, Striano, Pasquale, additional, Zara, Federico, additional, Campeau, Phillipe M., additional, and Sisodiya, S.M., additional

Published
2016
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22. TBC1D24 genotype-phenotype correlation: Epilepsies and other neurologic features.

Author

Balestrini, Simona, Milh, Mathieu, Castiglioni, Claudia, Lüthy, Kevin, Finelli, Mattea J, Verstreken, Patrik, Cardon, Aaron, Stražišar, Barbara Gnidovec, Holder, J Lloyd Jr, Lesca, Gaetan, Mancardi, Maria M, Poulat, Anne L, Repetto, Gabriela M, Banka, Siddharth, Bilo, Leonilda, Birkeland, Laura E, Bosch, Friedrich, Brockmann, Knut, Cross, J Helen, and Doummar, Diane

Published
2016
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23. Definition and diagnostic criteria of sleep-related hypermotor epilepsy.

Author

Tinuper, Paolo, Bisulli, Francesca, Cross, J. H., Hesdorffer, Dale, Kahane, Philippe, Nobili, Lino, Provini, Federica, Tassi, Laura, Vignatelli, Luca, Cirignotta, Fabio, Derry, Christopher, Gambardella, Antonio, Guerrini, Renzo, Halasz, Peter, Licchetta, Laura, Mahowald, Mark, Manni, Raffaele, Marini, Carla, Mostacci, Barbara, and Naldi, Ilaria

Published
2016
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26. Absence of antibodies to glutamate receptor type 3 (GluR3) in Rasmussen encephalitis

Author

Watson, R., primary, Jiang, Y., additional, Bermudez, I., additional, Houlihan, L., additional, Clover, L., additional, McKnight, K., additional, Cross, J. H., additional, Hart, I. K., additional, Roubertie, A., additional, Valmier, J., additional, Hart, Y., additional, Palace, J., additional, Beeson, D., additional, Vincent, A., additional, and Lang, B., additional

Published
2004
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27. Contrast-enhanced MR angiography for carotid disease

Author

U-King-Im, J. M., primary, Trivedi, R. A., additional, Graves, M. J., additional, Higgins, N. J., additional, Cross, J. J., additional, Tom, B. D., additional, Hollingworth, W., additional, Eales, H., additional, Warburton, E. A., additional, Kirkpatrick, P. J., additional, Antoun, N. M., additional, and Gillard, J. H., additional

Published
2004
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32. Outcome of Epilepsy Surgery in MRI-Negative Patients Without Histopathologic Abnormalities in the Resected Tissue.

Author

Sanders MW, Van der Wolf I, Jansen FE, Aronica E, Helmstaedter C, Racz A, Surges R, Grote A, Becker AJ, Rheims S, Catenoix H, Duncan JS, De Tisi J, Jacques TS, Cross JH, Kalviainen R, Rauramaa T, Chassoux F, Devaux BC, Di Gennaro G, Esposito V, Bodi I, Honavar M, Bien CG, Cloppenborg T, Coras R, Hamer HM, Marusic P, Kalina A, Pieper T, Kudernatsch M, Hartlieb TS, Von Oertzen TJ, Aichholzer M, Dorfmuller G, Chipaux M, Noachtar S, Kaufmann E, Schulze-Bonhage A, Scheiwe CF, Özkara C, Grunwald T, Koenig K, Guerrini R, Barba C, Buccoliero AM, Giordano F, Rosenow F, Menzler K, Garbelli R, Deleo F, Krsek P, Straka B, Arzimanoglou AA, Toulouse J, Van Paesschen W, Theys T, Pimentel J, Loução De Amorim IM, Specchio N, De Palma L, Feucht M, Scholl T, Roessler K, Toledano Delgado R, Gil-Nagel A, Raicevic S, Ristic AJ, Schijns O, Beckervordersandforth J, San Antonio-Arce V, Rumia J, Blumcke I, and Braun KP

Subjects
Humans, Cohort Studies, Electroencephalography, Magnetic Resonance Imaging, Retrospective Studies, Seizures, Treatment Outcome, Epilepsies, Partial diagnostic imaging, Epilepsies, Partial surgery, Epilepsy diagnostic imaging, Epilepsy surgery, Epilepsy, Temporal Lobe surgery
Abstract

Background and Objective: Patients with presumed nonlesional focal epilepsy-based on either MRI or histopathologic findings-have a lower success rate of epilepsy surgery compared with lesional patients. In this study, we aimed to characterize a large group of patients with focal epilepsy who underwent epilepsy surgery despite a normal MRI and had no lesion on histopathology. Determinants of their postoperative seizure outcomes were further studied., Methods: We designed an observational multicenter cohort study of MRI-negative and histopathology-negative patients who were derived from the European Epilepsy Brain Bank and underwent epilepsy surgery between 2000 and 2012 in 34 epilepsy surgery centers within Europe. We collected data on clinical characteristics, presurgical assessment, including genetic testing, surgery characteristics, postoperative outcome, and treatment regimen., Results: Of the 217 included patients, 40% were seizure-free (Engel I) 2 years after surgery and one-third of patients remained seizure-free after 5 years. Temporal lobe surgery (adjusted odds ratio [AOR]: 2.62; 95% CI 1.19-5.76), shorter epilepsy duration (AOR for duration: 0.94; 95% CI 0.89-0.99), and completely normal histopathologic findings-versus nonspecific reactive gliosis-(AOR: 4.69; 95% CI 1.79-11.27) were significantly associated with favorable seizure outcome at 2 years after surgery. Of patients who underwent invasive monitoring, only 35% reached seizure freedom at 2 years. Patients with parietal lobe resections had lowest seizure freedom rates (12.5%). Among temporal lobe surgery patients, there was a trend toward favorable outcome if hippocampectomy was part of the resection strategy (OR: 2.94; 95% CI 0.98-8.80). Genetic testing was only sporadically performed., Discussion: This study shows that seizure freedom can be reached in 40% of nonlesional patients with both normal MRI and histopathology findings. In particular, nonlesional temporal lobe epilepsy should be regarded as a relatively favorable group, with almost half of patients achieving seizure freedom at 2 years after surgery-even more if the hippocampus is resected-compared with only 1 in 5 nonlesional patients who underwent extratemporal surgery. Patients with an electroclinically identified focus, who are nonlesional, will be a promising group for advanced molecular-genetic analysis of brain tissue specimens to identify new brain somatic epilepsy genes or epilepsy-associated molecular pathways.

Published
2024
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33. Neurologic phenotypes associated with COL4A1 / 2 mutations: Expanding the spectrum of disease.

Author

Zagaglia S, Selch C, Nisevic JR, Mei D, Michalak Z, Hernandez-Hernandez L, Krithika S, Vezyroglou K, Varadkar SM, Pepler A, Biskup S, Leão M, Gärtner J, Merkenschlager A, Jaksch M, Møller RS, Gardella E, Kristiansen BS, Hansen LK, Vari MS, Helbig KL, Desai S, Smith-Hicks CL, Hino-Fukuyo N, Talvik T, Laugesaar R, Ilves P, Õunap K, Körber I, Hartlieb T, Kudernatsch M, Winkler P, Schimmel M, Hasse A, Knuf M, Heinemeyer J, Makowski C, Ghedia S, Subramanian GM, Striano P, Thomas RH, Micallef C, Thom M, Werring DJ, Kluger GJ, Cross JH, Guerrini R, Balestrini S, and Sisodiya SM

Subjects
Adolescent, Adult, Child, Child, Preschool, Epilepsy genetics, Female, Genetic Association Studies, Humans, Male, Mutation, Young Adult, Collagen Type IV genetics, Nervous System Diseases genetics, Nervous System Diseases pathology
Abstract

Objective: To characterize the neurologic phenotypes associated with COL4A1/2 mutations and to seek genotype-phenotype correlation., Methods: We analyzed clinical, EEG, and neuroimaging data of 44 new and 55 previously reported patients with COL4A1/COL4A2 mutations., Results: Childhood-onset focal seizures, frequently complicated by status epilepticus and resistance to antiepileptic drugs, was the most common phenotype. EEG typically showed focal epileptiform discharges in the context of other abnormalities, including generalized sharp waves or slowing. In 46.4% of new patients with focal seizures, porencephalic cysts on brain MRI colocalized with the area of the focal epileptiform discharges. In patients with porencephalic cysts, brain MRI frequently also showed extensive white matter abnormalities, consistent with the finding of diffuse cerebral disturbance on EEG. Notably, we also identified a subgroup of patients with epilepsy as their main clinical feature, in which brain MRI showed nonspecific findings, in particular periventricular leukoencephalopathy and ventricular asymmetry. Analysis of 15 pedigrees suggested a worsening of the severity of clinical phenotype in succeeding generations, particularly when maternally inherited. Mutations associated with epilepsy were spread across COL4A1 and a clear genotype-phenotype correlation did not emerge., Conclusion: COL4A1/COL4A2 mutations typically cause a severe neurologic condition and a broader spectrum of milder phenotypes, in which epilepsy is the predominant feature. Early identification of patients carrying COL4A1/COL4A2 mutations may have important clinical consequences, while for research efforts, omission from large-scale epilepsy sequencing studies of individuals with abnormalities on brain MRI may generate misleading estimates of the genetic contribution to the epilepsies overall., (Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.)

Published
2018
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34. Lateralization of brain function in childhood revealed by magnetic resonance spectroscopy.

Author

Gadian DG, Isaacs EB, Cross JH, Connelly A, Jackson GD, King MD, Neville BG, and Vargha-Khadem F

Subjects
Adolescent, Brain pathology, Child, Child, Preschool, Epilepsy, Temporal Lobe psychology, Female, Humans, Intelligence, Language Tests, Male, Models, Neurological, Neuropsychological Tests, Paired-Associate Learning, Brain physiopathology, Epilepsy, Temporal Lobe diagnosis, Epilepsy, Temporal Lobe physiopathology, Functional Laterality, Magnetic Resonance Spectroscopy
Abstract

We used proton magnetic resonance spectroscopy (1H MRS) for the assessment of focal brain pathology in 22 right-handed children with a diagnosis of intractable temporal lobe epilepsy, and we related this pathology to cognitive dysfunction. Cognitive assessment was based on measurements of verbal IQ, performance IQ, and the Paired Associate Learning subtest of the Wechsler Memory Scale. Five of the 22 children showed no abnormalities of the temporal lobes on 1H MRS, seven showed unilateral pathology, and 10 showed bilateral abnormalities. We found that left-sided pathology is associated with a loss of verbal cognitive functions, whereas right-sided pathology is associated with a loss of nonverbal functions. These findings are consistent with the pattern of lateralization of brain function that has been observed in adults.

Published
1996
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