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6 results on '"Holmes, L."'

1. Practice Parameter update: Management issues for women with epilepsy--Focus on pregnancy (an evidence-based review): Vitamin K, folic acid, blood levels, and breastfeeding: Report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and American Epilepsy Society

Author

Harden, C. L., primary, Pennell, P. B., additional, Koppel, B. S., additional, Hovinga, C. A., additional, Gidal, B., additional, Meador, K. J., additional, Hopp, J., additional, Ting, T. Y., additional, Hauser, W. A., additional, Thurman, D., additional, Kaplan, P. W., additional, Robinson, J. N., additional, French, J. A., additional, Wiebe, S., additional, Wilner, A. N., additional, Vazquez, B., additional, Holmes, L., additional, Krumholz, A., additional, Finnell, R., additional, Shafer, P. O., additional, and Le Guen, C., additional

Published
2009
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2. Practice Parameter update: Management issues for women with epilepsy--Focus on pregnancy (an evidence-based review): Teratogenesis and perinatal outcomes: Report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and American Epilepsy Society

Author

Harden, C. L., primary, Meador, K. J., additional, Pennell, P. B., additional, Hauser, W. A., additional, Gronseth, G. S., additional, French, J. A., additional, Wiebe, S., additional, Thurman, D., additional, Koppel, B. S., additional, Kaplan, P. W., additional, Robinson, J. N., additional, Hopp, J., additional, Ting, T. Y., additional, Gidal, B., additional, Hovinga, C. A., additional, Wilner, A. N., additional, Vazquez, B., additional, Holmes, L., additional, Krumholz, A., additional, Finnell, R., additional, Hirtz, D., additional, and Le Guen, C., additional

Published
2009
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3. Practice Parameter update: Management issues for women with epilepsy--Focus on pregnancy (an evidence-based review): Obstetrical complications and change in seizure frequency: Report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and American Epilepsy Society

Author

Harden, C. L., primary, Hopp, J., additional, Ting, T. Y., additional, Pennell, P. B., additional, French, J. A., additional, Hauser, W. A., additional, Wiebe, S., additional, Gronseth, G. S., additional, Thurman, D., additional, Meador, K. J., additional, Koppel, B. S., additional, Kaplan, P. W., additional, Robinson, J. N., additional, Gidal, B., additional, Hovinga, C. A., additional, Wilner, A. N., additional, Vazquez, B., additional, Holmes, L., additional, Krumholz, A., additional, Finnell, R., additional, and Le Guen, C., additional

Published
2009
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6. Increased rate of major malformations in offspring exposed to valproate during pregnancy.

Author

Wyszynski DF, Nambisan M, Surve T, Alsdorf RM, Smith CR, and Holmes LB

Subjects
Abnormalities, Drug-Induced physiopathology, Adult, Female, Humans, Infant, Newborn, Interviews as Topic, Male, North America epidemiology, Pregnancy, Pregnancy Trimester, First drug effects, Prenatal Exposure Delayed Effects physiopathology, Prevalence, Prospective Studies, Registries statistics & numerical data, Risk Factors, Abnormalities, Drug-Induced epidemiology, Anticonvulsants adverse effects, Epilepsy drug therapy, Prenatal Exposure Delayed Effects epidemiology, Valproic Acid adverse effects
Abstract

Objective: To determine the rate of occurrence of major malformations in infants whose mothers had taken the drug valproic acid (VPA) as monotherapy during the first trimester of pregnancy and had enrolled in the North American Antiepileptic Drug Pregnancy Registry., Methods: Data were collected from pregnant women throughout the United States and Canada through telephone-based interviews. Each woman was interviewed at enrollment, at 7 months' gestation, and postpartum. With her written permission, the medical records of each mother and her infant were obtained. The major malformations tabulated were those identified at or before 5 days of age. The prevalence of congenital malformations among offspring of monotherapy VPA-exposed women was compared with that among infants of women exposed to all other antiepileptic drugs (internal comparison group) and with that among newborns in the Active Malformations Surveillance Program at Brigham and Women's Hospital (external comparison group)., Results: Sixteen affected cases were identified among 149 VPA-exposed women (proportion: 10.7%; 95% CI: 6.3 to 16.9%). The prevalence in the internal comparison group was 2.9% (95% CI: 2.0 to 4.1%; odds ratio: 4.0, 95% CI: 2.1 to 7.4; p < 0.001). Assuming a 1.62% prevalence in the external comparison group, the relative risk of having an affected offspring for VPA-exposed women was 7.3 (95% CI: 4.4 to 12.2; p < 0.001)., Conclusion: Maternal exposure to valproic acid during the first trimester of pregnancy significantly increased the risk of major malformations.

Published
2005
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