1. Long-Term Dementia Risk in Parkinson Disease.
- Author
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Gallagher, Julia, Gochanour, Caroline, Caspell-Garcia, Chelsea, Dobkin, Roseanne, Aarsland, Dag, Alcalay, Roy, Barrett, Matthew, Chahine, Lana, Chen-Plotkin, Alice, Coffey, Christopher, Dahodwala, Nabila, Eberling, Jamie, Espay, Alberto, Leverenz, James, Litvan, Irene, Mamikonyan, Eugenia, Morley, James, Richard, Irene, Rosenthal, Liana, Siderowf, Andrew, Simuni, Tatyana, York, Michele, Willis, Allison, Xie, Sharon, and Weintraub, Daniel
- Subjects
Humans ,Parkinson Disease ,Dementia ,Male ,Female ,Aged ,Middle Aged ,Prospective Studies ,Cohort Studies ,Risk Factors ,Disease Progression ,Neuropsychological Tests ,Mental Status and Dementia Tests - Abstract
BACKGROUND AND OBJECTIVES: It is widely cited that dementia occurs in up to 80% of patients with Parkinson disease (PD), but studies reporting such high rates were published over two decades ago, had relatively small samples, and had other limitations. We aimed to determine long-term dementia risk in PD using data from two large, ongoing, prospective, observational studies. METHODS: Participants from the Parkinsons Progression Markers Initiative (PPMI), a multisite international study, and a long-standing PD research cohort at the University of Pennsylvania (Penn), a single site study at a tertiary movement disorders center, were recruited. PPMI enrolled de novo, untreated PD participants and Penn a convenience cohort from a large clinical center. For PPMI, a cognitive battery is administered annually, and a site investigator makes a cognitive diagnosis. At Penn, a comprehensive cognitive battery is administered either annually or biennially, and a cognitive diagnosis is made by expert consensus. Interval-censored survival curves were fit for time from PD diagnosis to stable dementia diagnosis for each cohort, using cognitive diagnosis of dementia as the primary end point and Montreal Cognitive Assessment (MoCA) score
- Published
- 2024