1. CD62L test at 2 years of natalizumab predicts progressive multifocal leukoencephalopathy
- Author
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Béatrice, Pignolet, Nicholas, Schwab, Tilman, Schneider-Hohendorf, Florence, Bucciarelli, Damien, Biotti, Delphine, Averseng-Peaureaux, Olivier, Outteryck, Jean-Claude, Ongagna, Jérôme, de Sèze, Bruno, Brochet, Jean-Christophe, Ouallet, Marc, Debouverie, Sophie, Pittion, Gilles, Defer, Nathalie, Derache, Patrick, Hautecoeur, Ayman, Tourbah, Pierre, Labauge, Giovanni, Castelnovo, Pierre, Clavelou, Eric, Berger, Jean, Pelletier, Audrey, Rico, Hélène, Zéphir, David, Laplaud, Sandrine, Wiertlewski, William, Camu, Eric, Thouvenot, Olivier, Casez, Thibault, Moreau, Agnès, Fromont, Sandra, Vukusic, Caroline, Papeix, Patrick, Vermersch, Manuel, Comabella, Christine, Lebrun-Frenay, Heinz, Wiendl, David, Brassat, Pôle neurosciences [Hôpital de Purpan - Toulouse], CHU Toulouse [Toulouse], Centre de Physiopathologie Toulouse Purpan (CPTP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Lille, CHU Strasbourg, Hôpital Pellegrin, CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Groupe Hospitalier de l'Institut Catholique de Lille (GHICL), Centre Hospitalier Universitaire de Reims (CHU Reims), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), CHU Clermont-Ferrand, Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Hôpital de la Timone [CHU - APHM] (TIMONE), Centre hospitalier universitaire de Nantes (CHU Nantes), CHU Grenoble, CHU Dijon, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Hospices Civils de Lyon (HCL), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre Hospitalier Universitaire de Nice (CHU Nice), Pôle Neurosciences [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Université catholique de Lille (UCL)
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Multiple Sclerosis ,genetic structures ,Sensitivity and Specificity ,03 medical and health sciences ,0302 clinical medicine ,Natalizumab ,Ophthalmology ,Sensation ,medicine ,Humans ,Immunologic Factors ,Prospective Studies ,L-Selectin ,ComputingMilieux_MISCELLANEOUS ,Retina ,business.industry ,Progressive multifocal leukoencephalopathy ,Leukoencephalopathy, Progressive Multifocal ,medicine.disease ,Prognosis ,eye diseases ,3. Good health ,030104 developmental biology ,medicine.anatomical_structure ,Phosphene ,Visual cortex ,Leukocytes, Mononuclear ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,sense organs ,Neurology (clinical) ,business ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,030217 neurology & neurosurgery ,Biomarkers ,medicine.drug ,Follow-Up Studies - Abstract
Flashes of light or phosphenes are the sensation of light without light actually entering the eye. This phenomenon can be evoked by stimulation of the retina or the visual cortex of the brain and can appear unilaterally or bilaterally. From an ophthalmologic perspective, phosphenes can arise from photoreceptor induction by mechanical,1,2 inflammatory,3 or vascular4 stimuli. Therefore, it is necessary to determine the origin of phosphenes for further management. We encountered a patient who reported having phosphenes while moving his eyes laterally. We performed various ophthalmologic imaging studies to identify the origin of these phosphenes. Acknowledgment: The authors thank Florence Umuhoza, Lise Scandella, and Sarah Exbrayat for technical assistance and the patients for participation in the study.
- Published
- 2016