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679 results on '"Rocca A"'

1. Tumefactive Demyelination in MOG Ab–Associated Disease, Multiple Sclerosis, and AQP-4-IgG–Positive Neuromyelitis Optica Spectrum Disorder

Author

Cacciaguerra, Laura, Morris, Pearse, Tobin, William O, Chen, John J, Banks, Samantha A., Elsbernd, Paul, Redenbaugh, Vyanka, Tillema, Jan-Mendelt, Montini, Federico, Sechi, Elia, Lopez-Chiriboga, A. Sebastian, Zalewski, Nicholas, Guo, Yong, Rocca, Maria A., Filippi, Massimo, Pittock, Sean J., Lucchinetti, Claudia Francesca, and Flanagan, Eoin P.

Published
2023
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7. Effects of Cognitive Rehabilitation on Brain Grey Matter Volume and Go-noGo Activity in Progressive Multiple Sclerosis: Results from the CogEx Study (S42.010)

Author

Rocca, Maria, primary, Valsasina, Paola, additional, Romano, Francesco, additional, Motl, Rob, additional, Amato, Maria, additional, Brichetto, Giampaolo, additional, Boccia, Daniele Vincenzo, additional, Chataway, Jeremy, additional, Chiaravalloti, Nancy, additional, Cutter, Gary, additional, Dalgas, Ulrik, additional, DeLuca, John, additional, Farrell, Rachel, additional, Feys, Peter, additional, Freeman, Jennifer, additional, Inglese, Matilde, additional, Meza, Cecilia, additional, Salter, Amber, additional, Sandroff, Brian, additional, Feinstein, Anthony, additional, and Filippi, Massimo, additional

Published
2024
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15. Brain MRI atrophy quantification in MS

Author

Rocca, Maria A, Battaglini, Marco, Benedict, Ralph HB, De Stefano, Nicola, Geurts, Jeroen JG, Henry, Roland G, Horsfield, Mark A, Jenkinson, Mark, Pagani, Elisabetta, and Filippi, Massimo

Subjects
Bioengineering, Neurosciences, Autoimmune Disease, Multiple Sclerosis, Clinical Research, Brain Disorders, Biomedical Imaging, Neurodegenerative, Neurological, Atrophy, Brain, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Clinical Sciences, Cognitive Sciences, Neurology & Neurosurgery
Abstract

Patients with the main clinical phenotypes of multiple sclerosis (MS) manifest varying degrees of brain atrophy beyond that of normal aging. Assessment of atrophy helps to distinguish clinically and cognitively deteriorating patients and predicts those who will have a less-favorable clinical outcome over the long term. Atrophy can be measured from brain MRI scans, and many technological improvements have been made over the last few years. Several software tools, with differing requirements on technical ability and levels of operator intervention, are currently available and have already been applied in research or clinical trial settings. Despite this, the measurement of atrophy in routine clinical practice remains an unmet need. After a short summary of the pathologic substrates of brain atrophy in MS, this review attempts to guide the clinician towards a better understanding of the methods currently used for quantifying brain atrophy in this condition. Important physiologic factors that affect brain volume measures are also considered. Finally, the most recent research on brain atrophy in MS is summarized, including whole brain and various compartments thereof (i.e., white matter, gray matter, selected CNS structures). Current methods provide sufficient precision for cohort studies, but are not adequate for confidently assessing changes in individual patients over the scale of months or a few years.

Published
2017

19. Timing and Predictors of T2-Lesion Resolution in Patients With Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease

Author

Cacciaguerra, Laura, primary, Redenbaugh, Vyanka, additional, Chen, John J., additional, Morris, Pearse, additional, Sechi, Elia, additional, Syc-Mazurek, Stephanie B., additional, Lopez-Chiriboga, A. Sebastian, additional, Tillema, Jan-Mendelt, additional, Rocca, Maria A., additional, Filippi, Massimo, additional, Pittock, Sean J., additional, and Flanagan, Eoin P., additional

Published
2023
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20. Association Between Fluctuations in Blood Lipid Levels Over Time With Incident Alzheimer Disease and Alzheimer Disease–Related Dementias

Author

Moser, Ethan D., primary, Manemann, Sheila M., additional, Larson, Nicholas B., additional, St Sauver, Jennifer L., additional, Takahashi, Paul Y., additional, Mielke, Michelle M., additional, Rocca, Walter A., additional, Olson, Janet E., additional, Roger, Véronique L., additional, Remaley, Alan T., additional, Decker, Paul A., additional, Killian, Jill M., additional, and Bielinski, Suzette J., additional

Published
2023
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21. Association of Hypertensive Disorders of Pregnancy With Cognition in Later Life

Author

Michelle M. Mielke, Ryan D. Frank, Luke R. Christenson, Julie A. Fields, Walter A. Rocca, and Vesna D. Garovic

Subjects
Neurology (clinical)
Abstract

Background and ObjectivesStudies of hypertensive disorders of pregnancy (HDP), including gestational or chronic hypertension (GH/CH) and preeclampsia/eclampsia (PE/E), suggest associations with early-life and mid-life cognition but have been limited by self-report or use of diagnostic codes, exclusion of nulliparous women, and lack of measurement of cognition in later life. We examined the effects of any HDP, GH/CH, PE/E, and nulliparity on cognition in later life.MethodsParticipants included 2,239 women (median age 73) enrolled in the Mayo Clinic Study of Aging with medical record–abstracted pregnancy information. A cognitive battery of 9 tests was conducted every 15 months. Global cognitive and domain-specific z scores (memory, executive/attention, visuospatial, and language) were outcomes. Linear mixed-effect models evaluated associations between pregnancy history (all normotensive, any HPD, HPD subtype [GH/CH, PE/E], or nulliparous) and cognitive decline, adjusting for age and education. Additional models adjusted for APOE, smoking, hypertension, dyslipidemia, body mass index (BMI), diabetes, stroke, and heart disease. Interactions between pregnancy history and age or education on cognitive performance were examined.ResultsOf the 2,239 women, 1,854 (82.8%) had at least 1 pregnancy (1,607 all normotensive, 100 GH/CH, and 147 PE/E); 385 (17.2%) were nulliparous. Cognitive performance did not cross-sectionally differ for women with a history of any HDP, GH/CH, or PE/E vs women with a history of all normotensive pregnancies; women who were nulliparous had lower global and domain-specific cognition (allp< 0.05) in age- and education-adjusted models. There was an interaction (p= 0.015) between nulliparity and education such that the lower cognitive performance was most pronounced among nulliparous women with ≤12 years of education (beta = −0.42,p< 0.001) vs 12 + years (b = −0.11,p= 0.049). Longitudinally, women with any HDP had greater declines in global cognition and attention/executive z scores compared with women with all normotensive pregnancies. When stratified by HDP type, only women with PE/E had greater declines in global cognition (beta = −0.04,p< 0.001), language (beta = −0.03,p= 0.001), and attention (beta = −0.04,p< 0.001) z scores. Adjustment for vascular risk factors, BMI, smoking, andAPOEdid not attenuate results.DiscussionWomen with a history of HDP, especially PE/E, are at greater risk of cognitive decline in later life.

Published
2023

29. Clinically relevant cranio-caudal patterns of cervical cord atrophy evolution in MS

Author

Rocca, Maria A., Valsasina, Paola, Meani, Alessandro, Gobbi, Claudio, Zecca, Chiara, Rovira, Àlex, Montalban, Xavier, Kearney, Hugh, Ciccarelli, Olga, Matthews, Lucy, Palace, Jacqueline, Gallo, Antonio, Bisecco, Alvino, Gass, Achim, Eisele, Philipp, Lukas, Carsten, Bellenberg, Barbara, Barkhof, Frederik, Vrenken, Hugo, Preziosa, Paolo, Comi, Giancarlo, and Filippi, Massimo

Published
2019
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30. Unraveling treatment response in multiple sclerosis: A clinical and MRI challenge

Author

Gasperini, Claudio, Prosperini, Luca, Tintoré, Mar, Sormani, Maria Pia, Filippi, Massimo, Rio, Jordi, Palace, Jacqueline, Rocca, Maria A., Ciccarelli, Olga, Barkhof, Frederik, Sastre-Garriga, Jaume, Vrenken, Hugo, Frederiksen, Jette L., Yousry, Tarek A., Enzinger, Christian, Rovira, Alex, Kappos, Ludwig, Pozzilli, Carlo, Montalban, Xavier, and De Stefano, Nicola

Published
2019
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34. Association of Gray Matter Atrophy Patterns With Clinical Phenotype and Progression in Multiple Sclerosis

Author

Maria A, Rocca, Paola, Valsasina, Alessandro, Meani, Claudio, Gobbi, Chiara, Zecca, Alex, Rovira, Jaume, Sastre-Garriga, Hugh, Kearney, Olga, Ciccarelli, Lucy, Matthews, Jacqueline, Palace, Antonio, Gallo, Alvino, Bisecco, Carsten, Lukas, Barbara, Bellenberg, Frederik, Barkhof, Hugo, Vrenken, Paolo, Preziosa, Massimo, Filippi, Tarek, Yousry, Rocca, M. A., Valsasina, P., Meani, A., Gobbi, C., Zecca, C., Rovira, A., Sastre-Garriga, J., Kearney, H., Ciccarelli, O., Matthews, L., Palace, J., Gallo, A., Bisecco, A., Lukas, C., Bellenberg, B., Barkhof, F., Vrenken, H., Preziosa, P., Filippi, M., Anatomy and neurosciences, Radiology and nuclear medicine, Amsterdam Neuroscience - Brain Imaging, Amsterdam Neuroscience - Neuroinfection & -inflammation, Rocca, Maria A, Valsasina, Paola, Meani, Alessandro, Gobbi, Claudio, Zecca, Chiara, Rovira, Alex, Sastre-Garriga, Jaume, Kearney, Hugh, Ciccarelli, Olga, Matthews, Lucy, Palace, Jacqueline, Gallo, Antonio, Bisecco, Alvino, Lukas, Carsten, Bellenberg, Barbara, Barkhof, Frederik, Vrenken, Hugo, Preziosa, Paolo, and Filippi, Massimo

Subjects
0301 basic medicine, Adult, Male, medicine.medical_specialty, Multiple Sclerosis, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Atrophy, Internal medicine, medicine, Humans, In patient, Gray Matter, Clinical phenotype, Clinically isolated syndrome, business.industry, Multiple sclerosis, Area under the curve, Brain, Odds ratio, Middle Aged, medicine.disease, Magnetic Resonance Imaging, 030104 developmental biology, Phenotype, Brain size, Disease Progression, Female, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

ObjectivesGay matter (GM) involvement is clinically relevant in multiple sclerosis (MS). Using source-based morphometry (SBM), we characterized GM atrophy and its 1-year evolution across different MS phenotypes.MethodsClinical and MRI data were obtained at 8 European sites from 170 healthy controls (HCs) and 398 patients with MS (34 with clinically isolated syndrome [CIS], 226 with relapsing-remitting MS [RRMS], 95 with secondary progressive MS [SPMS], and 43 with primary progressive MS [PPMS]). Fifty-seven HCs and 144 with MS underwent 1-year follow-up. Baseline GM loss, atrophy progression, and correlations with disability and 1-year clinical worsening were assessed.ResultsSBM identified 26 cerebellar, subcortical, sensory, motor, and cognitive GM components. GM atrophy was found in patients with MS vs HCs in almost all components (p range R2 = 0.65) with baseline lower normalized brain volume (β = −0.13, p = 0.001), greater sensorimotor GM atrophy (β = −0.12, p = 0.002), and longer disease duration (β = 0.09, p = 0.04). Baseline normalized GM volume (odds ratio 0.98, p = 0.008) and cerebellar GM atrophy (odds ratio 0.40, p = 0.01) independently predicted clinical worsening (area under the curve 0.83).ConclusionGM atrophy differed across disease phenotypes and progressed at 1 year in MS. In addition to global atrophy measures, sensorimotor and cerebellar GM atrophy explained baseline disability and clinical worsening.

Published
2020

36. Dynamic gray matter volume changes in pediatric multiple sclerosis

Author

Pierangelo Veggiotti, Massimo Filippi, Lucia Moiola, Maria A. Rocca, Ermelinda De Meo, Alessandro Meani, Angelo Ghezzi, De Meo, E., Meani, A., Moiola, L., Ghezzi, A., Veggiotti, P., Filippi, M., and Rocca, M. A.

Subjects
Male, 0301 basic medicine, medicine.medical_specialty, Multiple Sclerosis, Adolescent, computer.software_genre, White matter, Lesion, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Atrophy, Voxel, Internal medicine, Humans, Medicine, Clinical significance, Longitudinal Studies, Gray Matter, Child, Cerebral Cortex, Intelligence Tests, medicine.diagnostic_test, Intelligence quotient, business.industry, Multiple sclerosis, Magnetic resonance imaging, medicine.disease, Magnetic Resonance Imaging, 030104 developmental biology, medicine.anatomical_structure, Child, Preschool, Disease Progression, Linear Models, Cardiology, Female, Neurology (clinical), medicine.symptom, business, computer, 030217 neurology & neurosurgery, Follow-Up Studies
Abstract

ObjectivesTo assess, using MRI, the spatial patterns of gray matter (GM) atrophy in pediatric patients with multiple sclerosis (MS), their dynamic changes over time, and their clinical relevance.MethodsSixty-eight pediatric patients with MS (30 with a clinical and MRI follow-up after 3.5 years) and 26 healthy controls (HC) underwent clinical and MRI evaluation. To overcome difficulties in obtaining longitudinal scans in pediatric HC, a group of 317 pediatric HC from an NIH-funded MRI Study of Normal Brain Development was used to estimate GM developmental trajectories. In pediatric patients with MS, deviations from normative GM volume values at the voxel level were assessed at baseline and during the follow-up, using linear mixed-effects models. Correlations between GM volume deviations and disability, IQ, and white matter (WM) lesion volumes (LV) were estimated.ResultsPediatric patients with MS showed failures in GM development in several cortical and subcortical regions, as well as GM atrophy progression in most of these regions, which were only partially related to focal WM LV. Significant correlations were found between regional GM atrophy (particularly of deep GM regions) and disability, whereas higher IQ was associated with reduced deviations from age-expected GM volumes of specific GM regions at baseline and during the follow-up.ConclusionsImpaired GM maturation occurs in pediatric patients with MS, which is only partially driven by WM inflammation, suggesting that early neurodegenerative phenomena contribute to disability. High IQ, a measure of reserve, may offer protection by promoting remodeling of GM pruning in this young age.

Published
2019

41. Exploring in-vivo brain microstructural damage in multiple sclerosis through T1w/T2w-ratio mapping: a multicenter study (P14-4.009)

Author

Margoni, Monica, primary, Pagani, Elisabetta, additional, Meani, Alessandro, additional, Storelli, Loredana, additional, Mesaros, Sarlota, additional, Drulovic, Jelena, additional, Barkhof, Frederik, additional, Vrenken, Hugo, additional, Gallo, Antonio, additional, Bisecco, Alvino, additional, Pareto, Debora, additional, Sastre-Garriga, Jaume, additional, Ciccarelli, Olga, additional, Yiannakas, Marios, additional, Palace, Jacqueline, additional, Preziosa, Paolo, additional, Rocca, Maria A., additional, and Filippi, Massimo, additional

Published
2022
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47. Cortical remyelination failure predicts cortical atrophy and clinical progression in early multiple sclerosis (P2-4.008)

Author

Lazzarotto, Andrea, primary, Hamzaoui, Mariem, additional, Tonietto, Matteo, additional, Ricigliano, Vito, additional, Boffa, Giacomo, additional, Khalil, Michael, additional, Pirpamer, Lukas, additional, Ropele, Stefan, additional, Enzinger, Christian, additional, Battaglini, Marco, additional, Stromillo, Maria Laura, additional, De Stefano, Nicola, additional, Rocca, Maria, additional, Gallo, Paolo, additional, Gasperini, Claudio, additional, Stankoff, Bruno, additional, and Bodini, Benedetta, additional

Published
2022
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49. Spinal Cord Lesions and Brain Grey Matter Atrophy Independently Predict Clinical Worsening in Multiple Sclerosis: A 5-Year, Multicentre Study (P16-4.004)

Author

Rocca, Maria A., primary, Valsasina, Paola, additional, Meani, Alessandro, additional, Gobbi, Claudio, additional, Zecca, Chiara, additional, Barkhof, Frederik, additional, Schoonheim, Menno M., additional, Strijbis, Eva, additional, Vrenken, Hugo, additional, Gallo, Antonio, additional, Bisecco, Alvino, additional, Ciccarelli, Olga, additional, Yiannakas, Marios, additional, Rovira, Alex, additional, Sastre-Garriga, Jaume, additional, Palace, Jacqueline, additional, Matthews, Lucy, additional, Gass, Achim, additional, Eisele, Philipp, additional, Lukas, Carsten, additional, Bellenberg, Barbara, additional, Margoni, Monica, additional, Preziosa, Paolo, additional, and Filippi, Massimo, additional

Published
2022
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