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6. IFN-beta decreases adhesion and transmigration capacities of lymphocytes in Guillain-Barré syndrome.

Author

Créange A, Chazaud B, Plonquet A, Sharshar T, Poron F, Sonnet C, Raphaël JC, and Gherardi RK

Subjects
Cell Adhesion drug effects, Cell Adhesion immunology, Cell Movement drug effects, Cell Movement immunology, Dose-Response Relationship, Drug, Flow Cytometry, Humans, In Vitro Techniques, Integrin alpha4beta1, Integrins analysis, Lymphocyte Function-Associated Antigen-1 analysis, Lymphocytes chemistry, Receptors, Lymphocyte Homing analysis, Vascular Cell Adhesion Molecule-1 pharmacology, Adjuvants, Immunologic administration & dosage, Guillain-Barre Syndrome drug therapy, Guillain-Barre Syndrome immunology, Interferon-beta administration & dosage, Lymphocytes cytology
Abstract

The adhesion capacities, transmigration capacities, and integrin expression of lymphocytes from patients with Guillain-Barré syndrome incubated with interferon-beta were studied. Interferon-beta induced a dose-dependent inhibition of lymphocyte adhesion to recombinant vascular adhesion molecule-1 (p < 0.0001) and recombinant intercellular adhesion molecule-1 (rICAM-1) (p < 0.01) without modulation of very late activation molecule-4 and lymphocyte function-associated antigen-1 expressions and a dose-dependent decrease of lymphocyte transmigration across fibronectin (p < 0.0001). Inhibition of adhesion to rICAM-1 was similar after long (18 hours) or short (5 minutes) incubation time. These results support the potential therapeutic benefit of interferon-beta in Guillain-Barré syndrome.

Published
2001
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