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There are presented the results of combined examination of the state of vegetative nervous system in 94 patients with rheumatoid arthritis. By studying the variablity of cardiac rhythm in the sphere of vegetative regulation in patients dominance of sympathic tonicity mainly with asympathicotonic reactivity and deficient vegetative support of activity is determined. In majority of patients (90,4%) symptom complexes of vegetative dysfunction are found. Inclusion of dimephosphonum in combined therapy of rheumatoid arthritis led to normalization of indices of vegetative regulation and to significant diminishing of clinical manifestations of vegetative dysfunction.