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4 results on '"Arindam Biswas"'

1. Genetic Polymorphisms in DRD4 and Risk for Parkinson's Disease Among Eastern Indians

Author

Dipanwita, Sadhukhan, Arindam, Biswas, Atanu, Biswas, Kunal, Ray, and Jharna, Ray

Subjects
Genetic polymorphisms -- Research, Dopamine receptors -- Genetic aspects -- Health aspects, Neurological research, Parkinson's disease -- Risk factors -- Genetic aspects -- Demographic aspects, Health
Abstract

Byline: Sadhukhan. Dipanwita, Biswas. Arindam, Biswas. Atanu, Ray. Kunal, Ray. Jharna Background: Genetic factors, including causal gene and modifier genes, contribute significantly in PD pathogenesis in an ethnicity-dependent manner. Dopamine [...]

Published
2022

2. Mitochondrial DNA Haplogroups and Three Independent Polymorphisms have no Association with the Risk of Parkinson's Disease in East Indian Population

Author

Arindam Biswas, Mainak Sengupta, Kunal Ray, Rajashree Chakraborty, Tania Saha, Shyamal Kumar Das, Somrita Roy, and Jharna Ray

Subjects
Genetics, education.field_of_study, Mitochondrial DNA, Parkinson's disease, Genotype, business.industry, Population, India, Single-nucleotide polymorphism, Parkinson Disease, medicine.disease, DNA, Mitochondrial, Polymorphism, Single Nucleotide, Haplogroup, Neurology, Asian People, Haplotypes, Medicine, SNP, Humans, Neurology (clinical), business, education, Genetic association, Human mitochondrial DNA haplogroup
Abstract

Background Parkinson's disease (PD) is a multifaceted illness affecting ~ 0.3% of the world population. The genetic complexity of PD has not been, fully elucidated. Several studies suggest that mitochondrial DNA variants are associated with PD. Objective Here, we have explored the possibility of genetic association between mitochondrial haplogroups as well as three independent SNPs with PD in a representative east Indian population. Methods and material The Asian mtDNA haplogroups: M, N, R, B, D, M7, and 3 other SNPs: 4336 T/C, 9055 G/A, 13708 G/A were genotyped in 100 sporadic PD patients and 100 matched controls via conventional PCR-RFLP-sequencing approach. Results The distribution of mtDNA haplogroups, as well as 3 single polymorphisms, did not show any significant differences (P > 0.05) between patients and controls. Conclusion This is the first of its kind of study from India that suggests no association of selected mitochondrial DNA variations with PD.

Published
2021

3. Genetic Polymorphisms in and Risk for Parkinson's Disease Among Eastern Indians.

Author

Dipanwita, Sadhukhan, Arindam, Biswas, Atanu, Biswas, Kunal, Ray, and Jharna, Ray

Subjects
*CELL receptors, *GENETIC polymorphisms, *ALLELES, *PARKINSON'S disease, *HAPLOTYPES, *GENOTYPES
Abstract

Background: Genetic factors, including causal gene and modifier genes, contribute significantly in PD pathogenesis in an ethnicity-dependent manner. Dopamine Receptor 4 (DRD4), involved in dopamine metabolism is one such modifier locus for PD.Objective: To identify the potential association of DRD4 polymorphic variants with PD among Eastern Indians.Methods and Materials: PD-related DRD4 variants were genotyped among 291 PD patients and 265 ethnically matched controls from Eastern India.Results and Conclusion: Among the three DRD4 variants, only the 120 bp duplicated allele [P = 0.036; Odds ratio: 1.323; 95% CI: 1.014-1.725] and its homozygous genotype [P = 0.034; Odds ratio: 1.452; 95% CI: 1.025-2.057] were found as risk factors for overall PD and sporadic PD among Eastern Indians. However, no other disease-associated variant or haplotype was identified. Therefore, in conclusion, our study demonstrates that DRD4 plays a small role in PD pathogenesis among Eastern Indians. [ABSTRACT FROM AUTHOR]

Published
2022
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4. Movement disorders: Indian scenario: a clinico-genetic review

Author

Gautami Das, Arindam Biswas, Shyamal Kumar Das, Jharna Ray, and Bhaskar Ghosh

Subjects
medicine.medical_specialty, Neurology, Movement disorders, Movement Disorders, business.industry, Alternative medicine, Disease Management, India, Indian scenario, Survival Rate, Risk Factors, Epidemiology, Prevalence, Medicine, Humans, Neurology (clinical), medicine.symptom, business, Psychiatry
Abstract

Movement disorder (MD) is an important branch of neurology and has great potentiality in management because of improved diagnosis and therapeutic strategies. Over the last three decades, emphasis has been laid on the evaluation of various MDs in India by a limited number of interested neurologists and basic scientists. In this review, we want to highlight common problems of MDs in India with regard to epidemiology, clinical features and genetics.

Published
2013

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