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4 results on '"Painter, Michio"'

1. Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS.

Author

Omura, Takao, Omura, Kumiko, Tedeschi, Andrea, Riva, Priscilla, Painter, Michio W, Rojas, Leticia, Martin, Joshua, Lisi, Véronique, Huebner, Eric A, Latremoliere, Alban, Yin, Yuqin, Barrett, Lee B, Singh, Bhagat, Lee, Stella, Crisman, Tom, Gao, Fuying, Li, Songlin, Kapur, Kush, Geschwind, Daniel H, Kosik, Kenneth S, Coppola, Giovanni, He, Zhigang, Carmichael, S Thomas, Benowitz, Larry I, Costigan, Michael, and Woolf, Clifford J

Subjects
Neurosciences, Cognitive Sciences, Neurology & Neurosurgery, Psychology
Published
2016

2. Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS.

Author

Omura, Takao, Omura, Kumiko, Tedeschi, Andrea, Riva, Priscilla, Painter, Michio W, Rojas, Leticia, Martin, Joshua, Lisi, Véronique, Huebner, Eric A, Latremoliere, Alban, Yin, Yuqin, Barrett, Lee B, Singh, Bhagat, Lee, Stella, Crisman, Tom, Gao, Fuying, Li, Songlin, Kapur, Kush, Geschwind, Daniel H, Kosik, Kenneth S, Coppola, Giovanni, He, Zhigang, Carmichael, S Thomas, Benowitz, Larry I, Costigan, Michael, and Woolf, Clifford J

Subjects
Ganglia, Spinal, Axons, Animals, Mice, Inbred C3H, Mice, Inbred C57BL, Mice, Inbred DBA, Mice, Inbred NOD, Mice, Spinal Cord Injuries, Sciatic Neuropathy, Nerve Regeneration, Mice, 129 Strain, Ganglia, Spinal, Inbred C3H, Inbred C57BL, Inbred DBA, Inbred NOD, Strain, Spinal Cord Injury, Neurosciences, Injury - Trauma -, Genetics, Neurodegenerative, Regenerative Medicine, Brain Disorders, Stem Cell Research - Nonembryonic - Non-Human, Stem Cell Research, Injury (total) Accidents/Adverse Effects, 1.1 Normal biological development and functioning, Neurological, Neurology & Neurosurgery, Cognitive Sciences, Psychology
Abstract

Axon regeneration in the CNS requires reactivating injured neurons' intrinsic growth state and enabling growth in an inhibitory environment. Using an inbred mouse neuronal phenotypic screen, we find that CAST/Ei mouse adult dorsal root ganglion neurons extend axons more on CNS myelin than the other eight strains tested, especially when pre-injured. Injury-primed CAST/Ei neurons also regenerate markedly in the spinal cord and optic nerve more than those from C57BL/6 mice and show greater sprouting following ischemic stroke. Heritability estimates indicate that extended growth in CAST/Ei neurons on myelin is genetically determined, and two whole-genome expression screens yield the Activin transcript Inhba as most correlated with this ability. Inhibition of Activin signaling in CAST/Ei mice diminishes their CNS regenerative capacity, whereas its activation in C57BL/6 animals boosts regeneration. This screen demonstrates that mammalian CNS regeneration can occur and reveals a molecular pathway that contributes to this ability.

Published
2015

3. Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway

Author

Latremoliere, Alban, Latini, Alexandra, Andrews, Nick, Cronin, Shane J., Fujita, Masahide, Gorska, Katarzyna, Hovius, Ruud, Romero, Carla, Chuaiphichai, Surawee, Painter, Michio, Miracca, Giulia, Babaniyi, Olusegun, Remor, Aline Pertile, Duong, Kelly, Riva, Priscilla, Barrett, Lee B., Ferreirós, Nerea, Naylor, Alasdair, Penninger, Josef M., Tegeder, Irmgard, Zhong, Jian, Blagg, Julian, Channon, Keith M., Johnsson, Kai, Costigan, Michael, and Woolf, Clifford J.

Published
2015
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