1. Malignant epidermoid cyst of the pineal region with lumbar metastasis
- Author
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Ambrogio Brenna, Fabio Pagni, Giuseppe Isimbaldi, Biagio Eugenio Leone, Francesco Vergani, Pagni, F, Brenna, A, Leone, B, Vergani, F, and Isimbaldi, G
- Subjects
squamous cell carcinoma ,Pathology ,medicine.medical_specialty ,Epidermal Cyst ,Pathology and Forensic Medicine ,Metastasis ,Lesion ,Lumbar ,medicine ,Carcinoma ,Humans ,pineal region ,Spinal Cord Neoplasms ,Aged ,Gastrointestinal tract ,Lung ,business.industry ,epidermoid malignant cyst ,General Medicine ,Epidermoid cyst ,medicine.disease ,Hydrocephalus ,Cell Transformation, Neoplastic ,medicine.anatomical_structure ,hydrocephalu ,Carcinoma, Squamous Cell ,lumbar metastasi ,Female ,Neurology (clinical) ,Intracranial Hypertension ,medicine.symptom ,business ,Pinealoma - Abstract
This report describes a malignant neoplasia of the pineal region in a 65-year-old woman who presented with symptoms of intracranial hypertension and dissemination to CSF with radiologically documented lumbar intradural localizations. The histological examination of the lesion showed fragments of a cystic malignant neoplasia with epithelial elements resembling squamous cell carcinoma. We excluded the possibility of a cerebral metastasis from a squamous cell carcinoma arising in the genital or gastrointestinal tract, lung and skin. We propose this unique report for cyto- histological correlation and, as suggested in the American and Japanese literature, we discuss the hypothesis of the development of a squamous cell carcinoma arising from the malignant degeneration of a cerebral epidermoid cyst and we show by cytological examination of the CSF the exceptional presence of malignant cells and by lumbar MRI their intradural localizations.
- Published
- 2007
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