13 results on '"Sumihito Nobusawa"'
Search Results
2. Systemic inflammation caused by an intracranial mesenchymal tumor with a EWSR1 :: CREM fusion presenting associated with <scp>IL</scp> ‐6/ <scp>STAT3</scp> signaling
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Keishiro Hojo, Takuya Furuta, Satoru Komaki, Yukako Yoshikane, Jin Kikuchi, Hideo Nakamura, Mizuki Ide, Saho Shima, Yusuke Hiyoshi, Junichiro Araki, Seiji Tanaka, Shuichi Ozono, Akihiko Yoshida, Sumihito Nobusawa, Motohiro Morioka, and Ryuta Nishikomori more...
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Neurology (clinical) ,General Medicine ,Pathology and Forensic Medicine - Published
- 2022
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Catalog
3. Brainstem astroblastoma with MN1 translocation
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Sun Ah Shin, Seung-Ki Kim, Hyoung Jin Kang, Sumihito Nobusawa, Takashi Komori, Bokyung Ahn, and Sung Hye Park
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medicine.medical_specialty ,Pathology ,medicine.diagnostic_test ,Glial fibrillary acidic protein ,Astroblastoma ,General Medicine ,Gene rearrangement ,Biology ,medicine.disease ,Pathology and Forensic Medicine ,Meningioma ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Glioma ,medicine ,biology.protein ,Histopathology ,Neurology (clinical) ,Brainstem ,030217 neurology & neurosurgery ,Fluorescence in situ hybridization - Abstract
Astroblastoma is a rare glial neoplasm that occurs mostly in the cerebral hemisphere of children, adolescents and young adults. Although astroblastic perivascular pseudorosettes are unique histopathology of this neoplasm, diagnosis is usually challenging. Recently, it was discovered that the meningioma 1 gene (MN1)-altered pediatric central nervous system high-grade neuroepithelial tumors are actually astroblastomas. This case report presents a rare brainstem astroblastoma, with an unusual immunoprofile: negative for glial fibrillary acidic protein and oligodendrocyte transcription factor 2, but with a robust expression of pancytokeratin and epithelial membrane antigen. The diagnosis was confirmed based on the detection of MN1 rearrangement in a fluorescence in situ hybridization study, in addition to typical histopathology. Here we discuss the diagnostic pitfalls and unclear grading system along with a literature review. more...
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- 2018
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4. Anaplastic ganglioglioma with epithelioid cell components
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Masanori Aihara, Junko Hirato, Chiaki Murakami, Hayato Ikota, Sumihito Nobusawa, Ryosuke Shintoku, Hideaki Yokoo, Nozomi Matsumura, Yuhei Yoshimoto, and Tatsuya Yamazaki
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0301 basic medicine ,Pleomorphic xanthoastrocytoma ,Pathology ,medicine.medical_specialty ,General Medicine ,Radiological examination ,Biology ,medicine.disease ,Pathology and Forensic Medicine ,Ganglioglioma ,BRAF V600E ,03 medical and health sciences ,Epithelioid Glioblastoma ,030104 developmental biology ,0302 clinical medicine ,hemic and lymphatic diseases ,Anaplastic Ganglioglioma ,medicine ,Neurology (clinical) ,Epithelioid cell ,030217 neurology & neurosurgery ,Glioblastoma - Abstract
A 40-year-old man was admitted to our hospital because of disorientation and mild left-sided weakness. Radiological examination revealed a solid and cystic tumor in the right temporal lobe, and total resection was performed. Histologically, the tumor was composed mainly of low-grade gangiloglioma and had some high-grade glial components with focal necrosis and microvascular proliferations. In the high-grade component, there were epithelioid cells with round cytoplasm and eccentric nuclei. The high-grade area with epithelioid cells was intermingled within the low-grade area, which suggests that epithelioid cells were an anaplastic transformation of ganglioglioma. The epithelioid cells were histologically similar to neoplastic cells of epithelioid glioblastoma (E-GBM), a rare aggressive variant of isocitric dehydrogenase wild-type glioblastoma. A BRAF V600E mutation, frequently observed in E-GBM, was detected in both the ganglioglioma and epithelioid cell components. The epithelioid cells were mitotically active, which suggests that if the surgery was delayed, the histological appearance might have eventually evolved into E-GBM. Indeed, a case of pleomorphic xanthoastrocytoma which transformed into E-GBM after a long latency was reported elsewhere. This is the first report to describe focal epithelioid cells in anaplastic ganglioglioma. more...
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- 2018
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5. Gliosarcoma with primitive neuronal, chondroid, osteoid and ependymal elements
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Hayato Ikota, Hideaki Yokoo, Sumihito Nobusawa, Yuka Yoshida, Nozomi Matsumura, Hiroya Fujimaki, and Munenori Ide
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Mutation ,Pathology ,medicine.medical_specialty ,Gliosarcoma ,Ependymal Cell ,biology ,Slug ,Osteoid ,General Medicine ,biology.organism_classification ,medicine.disease ,medicine.disease_cause ,Pathology and Forensic Medicine ,03 medical and health sciences ,0302 clinical medicine ,Recurrent Gliosarcoma ,030220 oncology & carcinogenesis ,medicine ,Synaptophysin ,biology.protein ,Neurology (clinical) ,Fibrosarcoma ,030217 neurology & neurosurgery - Abstract
A 51-year-old man presented with a 2-week history of malaise. MRI revealed a large solid and cystic lesion with ring enhancement measuring 6.5 cm in diameter in the right frontal lobe. Histologically, the tumor consisted of various components: diffuse growth of atypical astrocytic cells consistent with glioblastoma, fascicular proliferation of atypical spindle cells such as fibrosarcoma, clusters of primitive neuronal cells, and foci of ependymal cells. The sarcomatous component also focally exhibited chondroid and osteoid differentiation. Immunohistochemically, tumor cells in the primitive neuronal component were immunoreactive for synaptophysin and CD56. The spindle cells were immunopositive for Slug and Twist, regulators of epithelial-mesenchymal transition. Direct DNA sequencing demonstrated C228T mutation in the TERT promoter in astrocytic, sarcomatous and primitive neuronal components, suggesting their identical origin. Although a few cases of gliosarcoma with primitive neuronal differentiation have previously been described, the finding that neuronal, glial and sarcomatous components share an identical mutation of the TERT promoter has not been reported. The tumor recurred at the original site 11 months after the first surgery. Interestingly, the recurrent tumor was composed exclusively of a glioblastomatous component, unlike past cases of recurrent gliosarcoma. more...
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- 2018
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6. Dentatorubral-pallidoluysian atrophy (DRPLA) with a small ganglioglioma component containing neurofibrillary tangles and polyglutamine aggregation
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Kazuyuki Mizushima, Satoshi Nakata, Tatsuya Yamazaki, Yasuo Harigaya, Hayato Ikota, Munenori Ide, Hideaki Yokoo, Junko Hirato, Seiji Yamada, and Sumihito Nobusawa
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0301 basic medicine ,Pathology ,medicine.medical_specialty ,Dentatorubral-pallidoluysian atrophy ,Neurodegeneration ,Central nervous system ,General Medicine ,Normal aging ,Autopsy case ,Biology ,medicine.disease ,Pathology and Forensic Medicine ,Ganglioglioma ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Atrophy ,medicine.anatomical_structure ,medicine ,Neurology (clinical) ,Brain examination ,030217 neurology & neurosurgery - Abstract
Dentatorubral-pallidoluysian atrophy (DRPLA), one of the polyglutamine diseases, has not been reported in combination with ganglioglioma (GG). Herein, we report an autopsy case of a 72-year-old man with DRPLA with a small GG component harboring neurofibrillary tangles (NFTs) and polyglutamine aggregates. NFTs, cytoplasmic accumulations of hyper-phosphorylated tau, are mainly observed in Alzheimer's disease (AD) and other tau-associated neurodegenerative disorders. NFTs can also be present in normal aging, and are occasionally observed in low-grade central nervous system (CNS) neoplasms such as GG. In the present case, whole brain examination demonstrated widespread deposition of polyglutamine aggregates, including GG, whereas NFTs were restricted to the GG component. In addition, no other AD or aging-related neuropathological structures were detected throughout the CNS. These findings may provide us with clues to elucidate the pathogenetic mechanisms that neuronal neoplasms may have to develop NFTs regardless of aging, and that polyglutamine may accumulate in neoplastic neurons in polyglutamine disease. more...
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- 2017
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7. Adult-onset atypical teratoid/rhabdoid tumor featuring long spindle cells with nuclear palisading and perivascular pseudorosettes
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Tadashi Miyamoto, Shinichi Uyama, Sumihito Nobusawa, Naomi Fujimoto, Hideaki Yokoo, Hidehisa Horiguchi, Satoshi Nakata, and Hiromi Ueta
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Pathology ,medicine.medical_specialty ,medicine.diagnostic_test ,biology ,Cell ,Mesenchymal stem cell ,Schwann cell ,Vimentin ,General Medicine ,medicine.disease ,Pathology and Forensic Medicine ,Staining ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Atypical teratoid rhabdoid tumor ,medicine ,biology.protein ,Neurology (clinical) ,030217 neurology & neurosurgery ,Actin ,Fluorescence in situ hybridization - Abstract
Atypical teratoid/rhabdoid tumors (AT/RTs) are rare malignant neoplasms of the CNS that preferentially affect young children. We herein report an adult case of AT/RT surviving for more than 5 years with the residual tumor. The patient, a 24-year-old man at onset, presented with a contrast-enhancing mass lesion in the left occipital lobe, and underwent partial tumor resection. Histologically, the tumor was predominantly composed of long spindle cells exhibiting nuclear palisading and perivascular pseudorosettes, which appeared to mimic mesenchymal, ependymal and Schwann cell tumors. A small number of isolated rhabdoid cells did not initially attract attention, and a tentative pathological diagnosis of a malignant mesenchymal tumor was made. In a later examination focusing on the small areas of rhabdoid cells, the extensive loss of the nuclear expression of INI1 was detected in all areas. Diffuse staining with vimentin and focal immunoreactivity for epithelial membrane antigen and alpha smooth muscle actin were observed not only in AT/RT foci, but also in spindle cell areas. Thus, polyphenotypic immunoreactivity was evident. Fluorescence in situ hybridization revealed a homozygous deletion of chromosome 22q covering the INI1 locus. Histopathological differences between infant and adult AT/RTs currently remain unclear. In the case of a malignant adult brain tumor showing a hardly classifiable morphology and immunophenotypic diversity, an analysis of the INI1 status may contribute to an accurate diagnosis. more...
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- 2016
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8. A case of an epithelioid glioblastoma with the BRAF V600E mutation colocalized with BRAF intact low-grade diffuse astrocytoma
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Shigetoshi Yano, Jun-ichiro Kuroda, Ryuta Ueda, Jun Ichi Kuratsu, Keishi Makino, Hideo Nakamura, Sumihito Nobusawa, and Hideaki Yokoo
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Pathology ,medicine.medical_specialty ,medicine.disease_cause ,Pathology and Forensic Medicine ,03 medical and health sciences ,0302 clinical medicine ,Diffuse Astrocytoma ,hemic and lymphatic diseases ,medicine ,neoplasms ,Mutation ,integumentary system ,business.industry ,Astrocytoma ,Histology ,General Medicine ,medicine.disease ,nervous system diseases ,BRAF V600E ,Epithelioid Glioblastoma ,030220 oncology & carcinogenesis ,Cancer research ,Neurology (clinical) ,business ,030217 neurology & neurosurgery ,V600E ,Calcification - Abstract
Epithelioid glioblastomas are one of the rarest histological variants of glioblastomas, which are not formally recognized by the World Health Organization (WHO) classification. Epithelioid glioblastomas usually occur as primary lesions, but there have been several reports of secondary epithelioid glioblastomas or epithelioid glioblastomas with pre- or co-existing lesions to date. The serine/threonine-protein kinase B-Raf (BRAF) V600E mutation has been found at a high frequency of 54% in epithelioid glioblastomas. We present a case of a 26-year-old female patient with an epithelioid glioblastoma with the BRAF V600E mutation in her right frontal lobe. In the present case, a low-grade diffuse astrocytoma component had colocalized with the epithelioid glioblastoma. The component presented prominent calcification on neuroimages as well as by histology, and low-grade diffuse astrocytoma was considered to be a precursor lesion of an epithelioid glioblastoma. However, the BRAF V600E mutation was detected only in epithelioid glioblastoma but not in low-grade diffuse astrocytoma. To the best of our knowledge, this is the first report demonstrating a discrepancy in the BRAF V600E mutation states between epithelioid glioblastoma and colocalized low-grade astrocytoma. more...
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- 2015
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9. Localized overexpression of alpha-internexin within nodules in multinodular and vacuolating neuronal tumors
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Ryotaro Suzuki, Akio Hyodo, Masaya Nagaishi, Yoshihiro Tanaka, Yoshiko Fujii, Yoshiki Sugiura, Sumihito Nobusawa, Kensuke Suzuki, and Hideaki Yokoo
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Pathology ,medicine.medical_specialty ,General Medicine ,Biology ,Pathology and Forensic Medicine ,Doublecortin ,OLIG2 ,Lesion ,Immunolabeling ,medicine.anatomical_structure ,nervous system ,Internexin ,Neuropil ,medicine ,biology.protein ,Synaptophysin ,Neurology (clinical) ,medicine.symptom ,NeuN - Abstract
Multinodular and vacuolating neuronal tumors (MVNT) have been recently referred to as a distinctive neuronal tumor entity based on histopathological findings. They are characterized by multiple tumor nodules, vacuolar alteration and widespread immunolabeling for human neuronal protein HuC/HuD. Only 13 cases have been reported in the literature to date and little is known about the histopathology of these tumors. Herein, we report a case of MVNT with additional confirmation of immunohistochemical features. A 22-year-old woman presented with a continuous headache. MRI showed a subcortical white matter lesion with multiple satellite nodules in the frontal lobe appearing as T2/fluid-attenuated inversion recovery (FLAIR) hyperintensities. Histological examination of the resected lesion revealed well-defined multiple nodules composed of predominant vacuolating tumor cells. The tumor cells exhibited consistent immunolabeling for doublecortin, as well as HuC/HuD, both representative neuronal biomarkers associated with earlier stages of neuronal development. Immunopositivity for oligodendrocyte transcription factor 2 (Olig2) and S100 was also detected in tumor cells. Additionally, significant overexpression of alpha-internexin was observed in the background neuropil limited to tumor nodules. Neuronal nuclear antigen (NeuN), synaptophysin and neurofilament, markers for mature neurons, were either negative or weakly positive. The expression profile of neuronal biomarkers can be distinguished from that of classic neuronal tumors and is the immunohistochemical hallmark of MVNT. In summary, we identified the characteristic tumoral expression of HuC/HuD and doublecortin and the presence of abundant neuropil localized in MVNT tumor nodules, which exhibited widespread alpha-internexin expression. These results supported the presumption that MVNT is a distinct histopathological entity. more...
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- 2015
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10. Malignant meningioma with adenocarcinoma-like metaplasia: Demonstration of intestinal phenotype
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Hayato Ikota, Sumihito Nobusawa, Hiroki Ishigame, Jun Nakayama, Hitoshi Watanabe, Junko Hirato, Ikuo Ochiai, Yoshiyasu Takayama, and Hideaki Yokoo
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Pathology ,medicine.medical_specialty ,Malignant meningioma ,General Medicine ,Biology ,medicine.disease ,Pathology and Forensic Medicine ,Metastatic carcinoma ,Meningioma ,Cytokeratin ,Metaplasia ,medicine ,Adenocarcinoma ,Neurology (clinical) ,medicine.symptom ,Anaplasia ,Secretory Meningioma - Abstract
Meningiomas show a diverse histopathologic appearance, often referred to as metaplastic changes; however, adenocarcinoma-like metaplasia is an extremely rare condition. Here, we present a novel case. A dura-based bulky mass located in the right frontotemporal region was identified radiologically in an 83-year-old woman. The tumor, yellow to ash-gray in color, was subtotally removed. Histopathological examination revealed robust adenocarcinoma-like structures within a conventional meningothelial neoplasm. Meningioma elements showed a WHO grade I to III histology. Morphological and immunophenotypic transition between meningothelial and columnar epithelial cells was confirmed on detailed observation. It was of note that the adenocarcinomatous components shared an immunophenotype with intestinal epithelium, expressing CDX2, MUC2 and cytokeratin 20. The present case could be differentiated from secretory meningioma based on distinct cellular atypia, lack of intracytoplasmic lumina and pseudosammoma bodies, and the intact status of the KLF4 gene. In addition, the morphological and immunophenotypic transition excluded the possibility of metastatic carcinoma within meningioma. This is the first reported case of meningioma with adenocarcinoma-like metaplasia harboring an intestinal immunophenotype. more...
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- 2014
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11. Cerebral astroblastoma in an adult: An immunohistochemical, ultrastructural and genetic study
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Shigekazu Takeuchi, Atsushi Shiga, Kouichirou Okamoto, Sumihito Nobusawa, Junko Hirato, Akiyoshi Kakita, Yong-Juan Fu, Yoshinori Taniguchi, Hitoshi Takahashi, and Yoichi Nakazato
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Pathology ,medicine.medical_specialty ,Ependymal Differentiation ,Astroblastoma ,General Medicine ,Anatomy ,Glial tumor ,Histogenesis ,Biology ,medicine.disease ,Pathology and Forensic Medicine ,OLIG2 ,Cytokeratin ,Diffuse Astrocytoma ,medicine ,Neurology (clinical) ,Hyaline - Abstract
Astroblastoma is a rare glial tumor of unknown origin, usually affecting the cerebral hemispheres of children and young adults. Here we report an unusual cerebral tumor in a 60-year-old woman. On MRI, the tumor appeared as a well circumscribed lesion in the left frontal lobe. Histopathologically, it was composed of rounded eosinophilic cells, and was divisible into two areas. One area was characterized by a collection of GFAP-positive cells around sclerotic blood vessels (astroblastic pseudorosettes and perivascular hyalinization), and had a Ki-67 labeling index of 2.8%. However, the other area was highly cellular, showing many GFAP-negative cells often with a rhabdoid appearance, mitoses and a Ki-67 index of 15.7%. Thus, a final diagnosis of malignant astroblastoma was made. In both areas of the tumor, nearly all the cells were positive for epithelial membrane antigen, and many were positive for oligodendrocyte transcription factor 2 (Olig2). Focal expression of cytokeratin was also evident. With regard to genetic markers, the tumor cells were positive for INI1 and negative for mutant IDH1. The p53 labeling index was more...
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- 2012
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12. Cytoplasmic iron deposition is associated with the expression of oxidative DNA damage marker in meningiomas
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Hayato Ikota, Yuko Tanaka, Tadashi Osawa, Yoichi Nakazato, Sumihito Nobusawa, Yuhei Yoshimoto, Masaya Nagaishi, and Hideaki Yokoo
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Pathology ,medicine.medical_specialty ,8-Hydroxy-2'-deoxyguanosine ,Microcystic Meningioma ,Transferrin receptor ,General Medicine ,Biology ,Cystic Change ,medicine.disease_cause ,medicine.disease ,nervous system diseases ,Pathology and Forensic Medicine ,Meningioma ,Benign Meningioma ,otorhinolaryngologic diseases ,medicine ,Neurology (clinical) ,neoplasms ,Pathological ,Oxidative stress - Abstract
Angiomatous meningiomas are rare meningioma subtypes, which are characterized by abundant, well-formed vessels. We encountered two cases of newly diagnosed angiomatous meningiomas exhibiting tumor cells with brown pigments, which were histochemically proven to be iron. In an attempt to understand its pathological significance, we assessed this unusual finding in representatives for each grade of meningiomas and immunoexpression of transferrin receptor (CD71) and the oxidative DNA damage marker, 8-hydroxy-2'-deoxyguanosine (8-OHdG). Iron deposition in the tumor cells was observed in 8/15 (53%) angiomatous meningioma cases, 2/6 (33%) microcystic meningiomas and 2/20 (10%) meningothelial meningiomas, which included clustered microvessels, but not in fibrous, atypical or anaplastic meningiomas (P = 0.001). Cytoplasmic CD71 expression was largely negative in angiomatous meningioma cases, but positive in meningothelial and high-grade meningiomas, suggesting that the transferrin-dependent iron transporter was involved in iron uptake in meningiomas. Nuclear expression of 8-OHdG was observed in ≥ 50% of the tumor cells in all 15 cases of angiomatous meningioma and was associated with the presence of regressive histopathological findings, such as hyalinized vessels and cystic changes. In addition, the fraction of iron-containing tumor cells was correlated to those expressing 8-OHdG (P = 0.005). Our finding indicates that cytoplasmic iron deposition in tumor cells is characteristic of highly vascularized benign meningiomas and related to increased oxidative DNA damage markers. more...
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- 2013
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13. Immunohistochemical and ultrastructural characterization of brain tumors in S100β-v-erbB transgenic rats
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Sumihito Nobusawa, Yoichi Nakazato, Hiroko Ohgaki, Yuko Tanaka, and Hideaki Yokoo
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Male ,Pathology ,medicine.medical_specialty ,Neurofilament ,Oligodendroglioma ,Brain tumor ,Nerve Tissue Proteins ,S100 Calcium Binding Protein beta Subunit ,Histogenesis ,Biology ,Pathology and Forensic Medicine ,OLIG2 ,ErbB ,Glioma ,Glial Fibrillary Acidic Protein ,Basic Helix-Loop-Helix Transcription Factors ,medicine ,Animals ,Nerve Growth Factors ,Homeodomain Proteins ,Brain Neoplasms ,S100 Proteins ,Nuclear Proteins ,Oncogene Proteins v-erbB ,General Medicine ,Oligodendrocyte Transcription Factor 2 ,Zebrafish Proteins ,medicine.disease ,Immunohistochemistry ,Rats ,Microscopy, Electron ,Homeobox Protein Nkx-2.2 ,Female ,Neurology (clinical) ,Rats, Transgenic ,Neuroglia ,Transcription Factors - Abstract
Transgenic rats expressing v-erbB (viral form of the EGF receptor) under transcriptional regulation by the S100beta promoter develop brain tumors (Ohgaki et al. J Neuropathol Experimental Neurol 65: 1111-1117, 2006). In the present study, we carried out detailed immunohistochemical and ultrastructural characterization of the brain tumors that developed in these rats. Of 49 homozygous transgenic rats between 16 and 94 weeks of age (mean, 59 weeks), 31 rats were autopsied because they showed severe neurological symptoms and/or became moribund. Among these, 30 rats had brain tumors, which were classified histologically as malignant glioma, anaplastic oligodendroglioma, and low-grade oligodendroglioma. Six transgenic rats developed two different histologic types of brain tumor, which were considered to be of multiclonal origin, because of the lack of histological transitions. All brain tumors contained neoplastic cells immunoreactive for S100 and GFAP. Diffuse immunoreactivity for Olig2 and Nkx2.2 was observed in neoplastic cells in all seven anaplastic oligodendrogliomas and in all three low-grade oligodendrogliomas analyzed, but in none of 26 malignant gliomas. Electron microscopy, carried out on four malignant gliomas and four anaplastic oligodendrogliomas, revealed the presence of intermediate filament bundles devoid of side arms, indicating glial differentiation. There was no evidence of cilia, microvilli, neurosecretory granules, synaptic structures or neurofilaments, excluding the possibility of ependymal or neuronal tumors. The present study thus provides additional evidence that the brain tumors developing in S100beta-v-erbB transgenic rats are of glial origin, with or without oligodendroglial differentiation. Reproducible development of three distinct histologic types of brain tumor in unique localizations may be explained by activation of the v-erbB transgene driven by the S100beta promoter in specific precursor cells during development of the brain. Thus, S100beta-v-erbB transgenic rats may be useful to study the histogenesis and molecular mechanisms of development of glial tumors due to disruption of the EGFR pathway. more...
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- 2008
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