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Start Over Author "Gregorio, L" Journal neuropharmacology
4 results on '"Gregorio, L"'

4. Properties of the corticostriatal long term depression induced by medial prefrontal cortex high frequency stimulation in vivo

Author

M. Gustavo Murer, Gregorio L. Galiñanes, Barbara Y. Braz, and Juan E. Belforte

Subjects
0301 basic medicine, Hippocampus, PREFRONTAL CORTEX, Striatum, DOPAMINE, Mice, 0302 clinical medicine, Piperidines, Receptor, Cannabinoid, CB1, Neural Pathways, Prefrontal cortex, Long-term depression, Neurons, purl.org/becyt/ford/3.1 [https], Medicina Básica, medicine.anatomical_structure, purl.org/becyt/ford/3 [https], Psychology, Motor cortex, medicine.drug, Heparin-binding EGF-like Growth Factor, CIENCIAS MÉDICAS Y DE LA SALUD, Interneuron, Tyrosine 3-Monooxygenase, Inmunología, Prefrontal Cortex, Mice, Transgenic, Choline O-Acetyltransferase, 03 medical and health sciences, Cellular and Molecular Neuroscience, Adrenergic Agents, Dopamine, medicine, Animals, Oxidopamine, Pharmacology, Long-Term Synaptic Depression, CORTICOSTRIATAL PLASTICITY, Benzazepines, Corpus Striatum, Mice, Inbred C57BL, 030104 developmental biology, NMDA, nervous system, Animals, Newborn, Forebrain, Dopamine Antagonists, Pyrazoles, Dizocilpine Maleate, Neuroscience, Excitatory Amino Acid Antagonists, 030217 neurology & neurosurgery
Abstract

Repetitive stimulation of cognitive forebrain circuits at frequencies capable of inducing corticostriatal long term plasticity is increasingly being used with therapeutic purposes in patients with neuropsychiatric disorders. However, corticostriatal plasticity is rarely studied in the intact brain. Our aim was to study the mechanisms of corticostriatal long term depression (LTD) induced by high frequency stimulation (HFS) of the medial prefrontal cortex in vivo. Our main finding is that the LTD induced in the dorsomedial striatum by medial prefrontal cortex HFS in vivo (prefrontostriatal LTD) is not affected by manipulations that block or reduce the LTD induced in the dorsolateral striatum by motor cortex HFS in brain slices, including pharmacological dopamine receptor and CB1 receptor blockade, chronic nigrostriatal dopamine depletion, CB1 receptor genetic deletion and selective striatal cholinergic interneuron (SCIN) ablation. Conversely, like in the hippocampus and other brain areas, prefrontostriatal LTD is NMDA receptor dependent. Thus, we describe a novel form of corticostriatal LTD that operates in brain circuits involved in reward and cognition and could be relevant for understanding the therapeutic effects of deep brain stimulation. Fil: Braz, Bárbara Yael. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina Fil: Belforte, Juan Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina Fil: Murer, Mario Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina Fil: Galiñanes, Gregorio Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina

Published
2017

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