1. DRD2/ANKK1 Polymorphism Modulates the Effect of Ventral Striatal Activation on Working Memory Performance
- Author
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Eric Artiges, Torkel Klingberg, Tobias Banaschewski, Frederike Schirmbeck, Sergi Costafreda Gonzalez, Herta Flor, Toni-Kim Clarke, Nadja Heym, RUBEN MIRANDA, Sylvane Desrivières, Frauke Nees, Michael Rapp, Edmund Lalor, Claire Lawrence, Arun Bokde, Simon Heath, Anita Opoku, Wolfgang Sommer, David Stacey, Andreas Heinz, Anbarasu Lourdusamy, Trevor Robbins, Colm Connolly, Margarita Moreno, Eva Mennigen, Charlotte Nymberg, Penny Gowland, and Steve Williams
- Subjects
Adult ,Male ,Adolescent ,Databases, Factual ,Genotype ,Individuality ,Caudate nucleus ,Striatum ,Neuropsychological Tests ,Protein Serine-Threonine Kinases ,Polymorphism, Single Nucleotide ,Young Adult ,Reward ,medicine ,Humans ,Child ,Pharmacology ,ANKK1 ,Receptors, Dopamine D2 ,Working memory ,Ventral striatum ,Dopaminergic ,Cognition ,Anticipation, Psychological ,Magnetic Resonance Imaging ,Anticipation ,Corpus Striatum ,Oxygen ,Psychiatry and Mental health ,Memory, Short-Term ,medicine.anatomical_structure ,Cerebrovascular Circulation ,Female ,Original Article ,Psychology ,Neuroscience - Abstract
Motivation is important for learning and cognition. Although dopaminergic (D2) transmission in the ventral striatum (VS) is associated with motivation, learning, and cognition are more strongly associated with function of the dorsal striatum, including activation in the caudate nucleus. A recent study found an interaction between intrinsic motivation and the DRD2/ANKK1 polymorphism (rs1800497), suggesting that A-carriers of rs1800497 are significantly more sensitive to motivation in order to improve during working memory (WM) training. Using data from the two large-scale imaging genetic data sets, IMAGEN (n=1080, age 13–15 years) and BrainChild (n∼300, age 6–27), we investigated whether rs1800497 is associated with WM. In the IMAGEN data set, we tested whether VS/caudate activation during reward anticipation was associated with WM performance and whether rs1800497 and VS/caudate activation interact to affect WM performance. We found that rs1800497 was associated with WM performance in IMAGEN and BrainChild. Higher VS and caudate activation during reward processing were significantly associated with higher WM performance (p
- Published
- 2014