1. Central respiratory effects of substance P in neonatal mice: an in vitro study
- Author
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Krzysztof Ptak, Gérard Hilaire, Dumonceaud, Corinne, Groupe d'étude des réseaux moteurs - GERM (GERMG), Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique (CNRS), Centre de recherche en neurobiologie - neurophysiologie de Marseille (CRN2M), and Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
MESH: Phrenic Nerve ,MESH: Substance P ,Substance P ,MESH: Animals, Newborn ,MESH: Spinal Cord ,Mice ,chemistry.chemical_compound ,0302 clinical medicine ,MESH: Animals ,Respiratory system ,Receptor ,[SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM] ,Phrenic nerve ,Mice, Inbred C3H ,0303 health sciences ,Respiration ,General Neuroscience ,Anatomy ,3. Good health ,Phrenic Nerve ,medicine.anatomical_structure ,Spinal Cord ,MESH: Neck ,Agonist ,medicine.medical_specialty ,MESH: Rats ,Respiratory rate ,MESH: Mice, Transgenic ,medicine.drug_class ,Central nervous system ,Mice, Transgenic ,In Vitro Techniques ,03 medical and health sciences ,Species Specificity ,Internal medicine ,medicine ,MESH: Species Specificity ,Animals ,[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM] ,MESH: Mice, Inbred C3H ,MESH: Mice ,030304 developmental biology ,MESH: Respiration ,business.industry ,Rats ,Endocrinology ,Monoamine neurotransmitter ,Animals, Newborn ,chemistry ,MESH: Brain Stem ,business ,Neck ,030217 neurology & neurosurgery ,Brain Stem - Abstract
Experiments were performed on neonatal mice to know whether substance P (SP) modified the rhythm and the amplitude of the phrenic bursts generated in vitro in brainstem-cervical cord preparations. In OF1 and C3H neonatal preparations, SP or the tachykinin NK1 receptor agonist [Sar9,Met(O2)11] substance P both increased significantly phrenic burst amplitude (10(-7) M) but had no significant effect on respiratory rhythm unless used at concentrations 10 times larger. In neonates from the monoamine oxidase-A deficient transgenic Tg8 line, SP increased phrenic burst amplitude but had no effect on the respiratory rhythm at the tested concentrations. The role of SP in regulating neonatal respiratory activity is discussed on the basis of rat and mouse results.
- Published
- 1999
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