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Your search keyword '"Ohsawa, Masahiro"' showing total 5 results
Start Over Author "Ohsawa, Masahiro" Journal neuroscience letters
5 results on '"Ohsawa, Masahiro"'

5. Involvement of beta-arrestin-2 in modulation of the spinal antinociception induced by mu-opioid receptor agonists in the mouse.

Author

Ohsawa M, Mizoguchi H, Narita M, Nagase H, Dun NJ, and Tseng LF

Subjects
Analgesics, Opioid pharmacology, Animals, Antibodies pharmacology, Antibodies physiology, Arrestins physiology, Dose-Response Relationship, Drug, Male, Mice, Mice, Inbred ICR, Pain Measurement methods, Receptors, Opioid, mu physiology, Spinal Cord physiology, beta-Arrestin 2, beta-Arrestins, Analgesics pharmacology, Arrestins pharmacology, Pain Measurement drug effects, Receptors, Opioid, mu agonists, Spinal Cord drug effects
Abstract

Beta-arrestins have been suggested to regulate mu-, delta-, and kappa-opioid receptor-mediated responses. In the present study, we examined the effects of pretreatment with beta-arrestin-2 antibody on tail-flick inhibition induced by opioid receptor agonists in the mouse spinal cord. Intrathecal (i.t.) pretreatment with beta-arrestin-2 antibody potentiated the antinociception induced by i.t.-administered mu-opioid receptor agonists [D-Ala(2),NMePhe(4),Gly-ol(5)]enkephalin (DAMGO) and endomorphin-1, but not endomorphin-2, the delta-opioid receptor agonist [D-Ala(2)]deltorphin II or the kappa-opioid receptor agonist U50,488H. The present result suggests that beta-arrestin-2 may tonically down-regulate a selected population of mu-opioid receptors activated by endomorphin-1 or DAMGO in the mouse spinal cord.

Published
2003
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