1. Spinal inhibitory synaptic transmission in the glycine receptor mouse mutant spastic
- Author
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von Wegerer, J., Becker, K., Glockenhammer, D., Becker, C.-M., Zeilhofer, H.U., and Swandulla, D.
- Subjects
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MOTOR neurons , *GLYCINE - Abstract
Inhibitory glycine receptor (GlyR) and GABAA receptor (GABAAR)-mediated synaptic transmission was examined in two strains of the GlyR mutant mouse spastic and the respective wild types. The mutants display a mild and a severe neurological phenotype. Electrically evoked postsynaptic whole-cell currents were recorded from α-motoneurons in lumbar spinal cord slices. Amplitudes of GlyR-mediated IPSCs were significantly reduced in the severe phenotype in comparison to the respective wild type and the mild phenotype mutants. Surprisingly, amplitudes of GABAAR-mediated IPSCs were also significantly reduced in both mutants. Fast time constants of the decay phase of IPSCs were slightly reduced for the GlyR-mediated IPSCs and significantly larger for the GABAAR-mediated IPSCs in both mutant strains. [Copyright &y& Elsevier]
- Published
- 2003
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