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23 results on '"Higashijima, A."'

3. Genetic manipulation of mammalian lateral and medial habenula homolog in zebrafish: Toward functional analysis of the habenula

Author

Amo, Ryunosuke, primary, Agetsuma, Masakazu, additional, Kinoshita, Masae, additional, Shiraki, Toshiyuki, additional, Higashijima, Shin-ichi, additional, Matsuda, Masaru, additional, Suster, Maximiliano L., additional, Kawakami, Koichi, additional, Ohshima, Toshio, additional, Aizawa, Hidenori, additional, and Okamoto, Hitoshi, additional

Published
2011
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10. Genetic manipulation of mammalian lateral and medial habenula homolog in zebrafish: Toward functional analysis of the habenula

Author

Masae Kinoshita, Toshio Ohshima, Hidenori Aizawa, Toshiyuki Shiraki, Masakazu Agetsuma, Hitoshi Okamoto, Maximiliano L. Suster, Shin-ichi Higashijima, Ryunosuke Amo, Koichi Kawakami, and Masaru Matsuda

Subjects
Habenula, biology, Functional analysis, General Neuroscience, General Medicine, Medial habenula, biology.organism_classification, Neuroscience, Zebrafish
Published
2011

17. Activation of distinct neural ensemble in zebrafish telencephalon following the go/no-go rule change in the goal directed active avoidance learning

Author

Hitoshi Okamoto, Ryo Aoki, Hidenori Aizawa, Masakazu Agetsuma, Tazu Aoki, Shin-ichi Higashijima, and Akiko Arata

Subjects
Communication, biology, Cerebrum, business.industry, General Neuroscience, General Medicine, biology.organism_classification, medicine.anatomical_structure, Neural ensemble, Avoidance learning, Go/no go, medicine, Psychology, business, Zebrafish, Neuroscience
Published
2010

21. Functional role of a specialized class of spinal commissural inhibitory neurons during fast escapes in zebrafish

Author

Shin-ichi Higashijima, Kazuki Horikawa, Hiroyuki Takeda, Tsunehiko Kohashi, Chie Satou, Yukiko Kimura, and Yoichi Oda

Subjects
Functional role, Patch-Clamp Techniques, Green Fluorescent Proteins, Biotin, Biology, Inhibitory postsynaptic potential, Membrane Potentials, Green fluorescent protein, Animals, Genetically Modified, Escape Reaction, Interneurons, Neural Pathways, Animals, Gene silencing, Zebrafish, Swimming, Behavior, Animal, Rhodamines, General Neuroscience, Gap Junctions, Dextrans, Neural Inhibition, Articles, General Medicine, Commissure, biology.organism_classification, Electric Stimulation, digestive system diseases, Electrophysiology, Inhibitory Postsynaptic Potentials, Spinal Cord, Larva, Calcium, Laser Therapy, Brainstem, Neuroscience
Abstract

In teleost fish, the Mauthner (M) cell, a large reticulospinal neuron in the brainstem, triggers escape behavior. Spinal commissural inhibitory interneurons that are electrotonically excited by the M-axon have been identified, but the behavioral roles of these neurons have not yet been addressed. Here, we studied these neurons, named CoLo (commissural local), in larval zebrafish using an enhancer-trap line in which the entire population of CoLos was visualized by green fluorescent protein. CoLos were present at one cell per hemi-segment. Electrophysiological recordings showed that an M-spike evoked a spike in CoLos via electrotonic transmission and that CoLos made monosynaptic inhibitory connections onto contralateral primary motoneurons, consistent with the results in adult goldfish. We further showed that CoLos were active only during escapes. We examined the behavioral roles of CoLos by investigating escape behaviors in CoLo-ablated larvae. The results showed that the escape behaviors evoked by sound/vibration stimuli were often impaired with a reduced initial bend of the body, indicating that CoLos play important roles in initiating escapes. We obtained several lines of evidence that strongly suggested that the impaired escapes occurred during bilateral activation of the M-cells: in normal larvae, CoLo-mediated inhibitory circuits enable animals to perform escapes even in these occasions by silencing the output of the slightly delayed firing of the second M-cell. This study illustrates (1) a clear example of the behavioral role of a specialized class of interneurons and (2) the capacity of the spinal circuits to filter descending commands and thereby produce the appropriate behavior.

Published
2009

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