4 results on '"Laura B. Ngwenya"'
Search Results
2. Autonomic dysfunction following traumatic brain injury: translational insights
- Author
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George Yang, Jennifer L. McGuire, Laura B. Ngwenya, Fatima Khalid, Brandon Foreman, Matthew J Robson, and John N Lorenz
- Subjects
medicine.medical_specialty ,Traumatic brain injury ,Length of hospitalization ,Kidney ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Brain Injuries, Traumatic ,medicine ,Autonomic dysregulation ,Humans ,Autoregulation ,Paroxysmal sympathetic hyperactivity ,Organ system ,business.industry ,Brain ,Heart ,General Medicine ,medicine.disease ,Pathophysiology ,nervous system diseases ,medicine.anatomical_structure ,Autonomic Nervous System Diseases ,Cardiology ,Surgery ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Although there is a substantial amount of research on the neurological consequences of traumatic brain injury (TBI), there is a knowledge gap regarding the relationship between TBI and the pathophysiology of organ system dysfunction and autonomic dysregulation. In particular, the mechanisms or incidences of renal or cardiac complications after TBI are mostly unknown. Autonomic dysfunction following TBI exacerbates secondary injury and may contribute to nonneurologial complications that prolong hospital length of stay. Gaining insights into the mechanisms of autonomic dysfunction can guide advancements in monitoring and treatment paradigms to improve acute survival and long-term prognosis of TBI patients. In this paper, the authors will review the literature on autonomic dysfunction after TBI and possible mechanisms of paroxysmal sympathetic hyperactivity. Specifically, they will discuss the link among the brain, heart, and kidneys and review data to direct future research on and interventions for TBI-induced autonomic dysfunction.
- Published
- 2019
3. Examining the Emergency Medical Treatment and Active Labor Act: impact on telemedicine for neurotrauma
- Author
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James Wright, Christina Gerges, Ann M. Parr, Diana T. Le, Sanjit Shah, Laura B. Ngwenya, George Yang, and Joseph S. Cheng
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Emergency Medical Services ,Telemedicine ,Pneumonia, Viral ,Context (language use) ,Centers for Medicare and Medicaid Services, U.S ,030218 nuclear medicine & medical imaging ,Tertiary Care Centers ,Betacoronavirus ,03 medical and health sciences ,0302 clinical medicine ,Health care ,Pandemic ,Emergency medical services ,medicine ,Humans ,Pandemics ,Socioeconomic status ,Brain Concussion ,SARS-CoV-2 ,business.industry ,COVID-19 ,General Medicine ,medicine.disease ,Emergency Medical Treatment and Active Labor Act ,United States ,Work (electrical) ,Surgery ,Neurology (clinical) ,Medical emergency ,Coronavirus Infections ,business ,030217 neurology & neurosurgery - Abstract
The Emergency Medical Treatment and Active Labor Act (EMTALA) protects patient access to emergency medical treatment regardless of insurance or socioeconomic status. A significant result of the COVID-19 pandemic has been the rapid acceleration in the adoption of telemedicine services across many facets of healthcare. However, very little literature exists regarding the use of telemedicine in the context of EMTALA. This work aimed to evaluate the potential to expand the usage of telemedicine services for neurotrauma to reduce transfer rates, minimize movement of patients across borders, and alleviate the burden on tertiary care hospitals involved in the care of patients with COVID-19 during a global pandemic. In this paper, the authors outline EMTALA provisions, provide examples of EMTALA violations involving neurosurgical care, and propose guidelines for the creation of telemedicine protocols between referring and consulting institutions.
- Published
- 2020
- Full Text
- View/download PDF
4. Blunt cerebrovascular injury in the geriatric population
- Author
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Kinsey A. Barhorst, Laura B. Ngwenya, George Yang, James Castiglione, Sanjit Shah, Charles J. Prestigiacomo, Roman Jandarov, Diana T. Le, Shaun Keegan, and Sarah Schuman Harlan
- Subjects
Adult ,medicine.medical_specialty ,Population ageing ,Computed Tomography Angiography ,Vertebral artery ,Neurological morbidity ,Wounds, Nonpenetrating ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Blunt ,Geriatric population ,Internal medicine ,medicine.artery ,medicine ,Humans ,Cerebrovascular Trauma ,Vertebral Artery ,Aged ,Retrospective Studies ,Geriatrics ,medicine.diagnostic_test ,business.industry ,Trauma center ,General Medicine ,Angiography ,Surgery ,Neurology (clinical) ,Carotid Artery Injuries ,business ,030217 neurology & neurosurgery - Abstract
OBJECTIVEBlunt cerebrovascular injury (BCVI) is associated with high rates of neurological morbidity and mortality. The detection and management of BCVI has improved with advances in imaging and sensitive screening protocols. Few studies have explored how these injuries specifically affect the geriatric population. The purpose of this retrospective analysis was to investigate the presentation and prognosis of BCVI in the elderly population and to assess its clinical implications in the management of these patients.METHODSAll patients presenting to the University of Cincinnati (UC) level I trauma center between February 2017 and December 2019 were screened for BCVI and entered into the prospectively maintained UC Neurotrauma Registry. Patients with BCVI confirmed by CT angiography underwent retrospective chart reviews to collect information regarding demographics, positive screening criteria, cause of injury, antithrombotic agent, injury location, Denver Grading Scale, hospital and ICU length of stay, and discharge disposition. Patients were divided into geriatric (age ≥ 65 years) and adult (age < 65 years) subgroups. Continuous variables were analyzed using the Student t-test and categorical variables with the Pearson chi-square test.RESULTSOf 124 patients with BCVI, stratification by age yielded 23 geriatric and 101 adult patients. Injury in the geriatric group was associated with significantly higher mortality (p = 0.0194). The most common cause of injury in the elderly was falls (74%, 17/23; p < 0.0001), whereas motor vehicle accidents were most common in the adult group (38%, 38/100; p = 0.0642). With respect to the location of injury, carotid (p = 0.1171) and vertebral artery (p = 0.6981) injuries did not differ significantly for the geriatric group. The adult population presented more often with Denver grade I injuries (p < 0.0001), whereas the geriatric population presented with grade IV injuries (p = 0.0247). Elderly patients were more likely to be discharged to skilled nursing facilities (p = 0.0403) and adults to home or self-care (p = 0.0148).CONCLUSIONSThis study is the first to characterize BCVI to all cervical and intracranial vessels in the geriatric population. Older age at presentation is significantly associated with greater severity, morbidity, and mortality from injury, with no preference for the particular artery injured. These findings carry important clinical implications for adapting practice in an aging population.
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- 2020
- Full Text
- View/download PDF
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