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The article focuses on the study regarding the impact of preexposure prophylaxis for HIV. It states that there was a possibility of developing resistance tot the antiviral agents used in the HIV acquired during preexposure prophylaxis. It says that a management plan was needed when recommending preexposure prophylaxis which recognizes the intervention's effect on the sexual behavior and well-being of the patient.

The author comments on the Strategies for Management of Antiretroviral Therapy (SMART) trial that was carried out to determine whether withholding therapy for long periods would result in human immunodeficiency viruses (HIV)-associated complications. According to the author, the results of the SMART study underscore the benefit of using adequately powered randomized trials to evaluate new treatment strategies in clinical medicine.