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Your search keyword '"Akkerhuis, Jurgen"' showing total 3 results
Start Over Author "Akkerhuis, Jurgen" Journal new england journal of medicine
3 results on '"Akkerhuis, Jurgen"'

1. Swinging Heart.

Author

Akkerhuis, Jurgen M. and Hersbach, Ferry M.R.J.

Subjects
*LUNG cancer, *SYNCOPE, *HEART disease diagnosis, *DIAGNOSIS, *TACHYCARDIA, *HEALTH of older men
Abstract

A 49-year-old man with small-cell lung carcinoma was admitted because of syncope. On examination, he had tachycardia (heart rate, 106 beats per minute), distended jugular veins, and muffled heart sounds. The blood pressure was 90/60 mm Hg. Pulsus paradoxus was not detected. The 12-lead electrocardiogram showed low QRS voltages with electrical alternans in multiple leads and flattening of the T waves (Panel A). Transthoracic echocardiography showed massive pericardial effusion and diastolic collapse of the right atrium and ventricle. Pericardiocentesis yielded 800 ml of fluid that was cytologically positive for pericarditis carcinomatosa. Immediately after the aspiration, the patient's hemodynamic condition improved. Correlation between the QRS alternation and a pendular swinging of the heart within the pericardial space is visible on the echocardiogram.

Published
2004
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2. Evinacumab for Homozygous Familial Hypercholesterolemia

Author

Gerald Watts, Farrah Deeba, David Sullivan, Paul Donald Bonnitcha, San San Min, Nimalie Jacintha Nanayakkara, Christopher Ebenbichler, Alexander Tschoner, Clemens Engler, Daniel Gaudet, Nathalie Roy, David Blackburn, Jean Bergeron, Hisee Villeneuve, Samir Saheb, Antonio Gallo, Sophia Beliard, Bertrand Dussol, Sophie Morange, Pascale Poullin, Rene Valero, Charalampos Milionis, Sebastian Filippas-Ntekouan, Eleftherios Klouras, Genovefa Kolovou, George Hatzigeorgiou, Spyridon Rammos, Paolo Rubba, Gabriella Iannuzzo, Mariko Harada-Shiba, Cheol Son, Hisashi Makino, Kiminori Hosoda, Kota Matsuki, Kyoko Kohmo, Masaki Matsubara, Masatsune Ogura, Michio Noguchio, Miki Matsuo, Ryo Koezuka, Tamiko Tamanaha, Tsutomu Tomita, Yoko Ohata, Yoshihiko Otsubo, Noriaki Koyanagi, Masaaki Kawashiri, Hayato Tada, Atsushi Nohara, Akihiro Nomura, Hirofumi Okada, Naohiko Fujii, Daisuke Hayashi, Sayoko Yonemoto, Shungo Fukuda, Koji Yanagi, Miwa Ryo, Masahiro Koseki, Makoto Nishida, Takeshi Okada, Erik Stroes, Laurens Reeskamp, Daniela Stols-Goncalves, Eva Hamulyak, Anho H Liem, Jurgen M Akkerhuis, Pieter R Nierop, Bastiaan M van Dalen, Sweder W E van de Poll, Adriana J M van Miltenburg-van Zijl, Marinus J Veerhoek, Frederick Raal, Sindeep Amrat Bhana, Olena Mitchenko, Vadym Romanov, Iryna Chulaevska, Leonid Rudenko, Olena Beregova, Igor Vakaliuk, Iryna Drapchak, Natalia Tymochko, Anna Isayeva, Olena Buriakovska, Maryna Vovchenko, Vira Tseluyko, Nataliya Matviychuk, Larysa Yakovleva, Paul Duell, Jonathan Barton Purnell, Robert Rosenson, Donald Smith, Theresa Halloran, Robert Gottlieb, Peter A McCullough, Zachary P Rosol, Andy Y Lee, Clay M Barbin, Seth J Baum, Reina Mendelson, Melissa Wright, Linda Hemphill, Akl Fahed, Traci Turner, Angela Ellard, Gerald Watts, ., Deeba, Farrah, Sullivan, David, Donald Bonnitcha, Paul, San Min, San, Jacintha Nanayakkara, Nimalie, Ebenbichler, Christopher, Tschoner, Alexander, Engler, Clemen, Gaudet, Daniel, Roy, Nathalie, Blackburn, David, Bergeron, Jean, Villeneuve, Hisee, Saheb, Samir, Gallo, Antonio, Beliard, Sophia, Dussol, Bertrand, Morange, Sophie, Poullin, Pascale, Valero, Rene, Milionis, Charalampo, Filippas-Ntekouan, Sebastian, Klouras, Eleftherio, Kolovou, Genovefa, Hatzigeorgiou, George, Rammos, Spyridon, Rubba, PAOLO OSVALDO FEDERICO, Iannuzzo, Gabriella, Harada-Shiba, Mariko, Son, Cheol, Makino, Hisashi, Hosoda, Kiminori, Matsuki, Kota, Kohmo, Kyoko, Matsubara, Masaki, Ogura, Masatsune, Noguchio, Michio, Matsuo, Miki, Koezuka, Ryo, Tamanaha, Tamiko, Tomita, Tsutomu, Ohata, Yoko, Otsubo, Yoshihiko, Koyanagi, Noriaki, Kawashiri, Masaaki, Tada, Hayato, Nohara, Atsushi, Nomura, Akihiro, Okada, Hirofumi, Fujii, Naohiko, Hayashi, Daisuke, Yonemoto, Sayoko, Fukuda, Shungo, Yanagi, Koji, Ryo, Miwa, Koseki, Masahiro, Nishida, Makoto, Okada, Takeshi, Stroes, Erik, Reeskamp, Lauren, Stols-Goncalves, Daniela, Hamulyak, Eva, H Liem, Anho, M Akkerhuis, Jurgen, R Nierop, Pieter, M van Dalen, Bastiaan, E van de Poll, Sweder W, M van Miltenburg-van Zijl, Adriana J, J Veerhoek, Marinu, Raal, Frederick, Amrat Bhana, Sindeep, Mitchenko, Olena, Romanov, Vadym, Chulaevska, Iryna, Rudenko, Leonid, Beregova, Olena, Vakaliuk, Igor, Drapchak, Iryna, Tymochko, Natalia, Isayeva, Anna, Buriakovska, Olena, Vovchenko, Maryna, Tseluyko, Vira, Matviychuk, Nataliya, Yakovleva, Larysa, Duell, Paul, Barton Purnell, Jonathan, Rosenson, Robert, Smith, Donald, Halloran, Theresa, Gottlieb, Robert, A McCullough, Peter, P Rosol, Zachary, Y Lee, Andy, M Barbin, Clay, J Baum, Seth, Mendelson, Reina, Wright, Melissa, Hemphill, Linda, Fahed, Akl, Turner, Traci, Ellard, Angela, Graduate School, Vascular Medicine, ACS - Atherosclerosis & ischemic syndromes, Experimental Vascular Medicine, and ACS - Pulmonary hypertension & thrombosis

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Evinacumab, Angiopoietin-like Protein, Disease, Familial hypercholesterolemia, 030204 cardiovascular system & hematology, Hyperlipoproteinemia Type II, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Double-Blind Method, Internal medicine, Anticholesteremic Agent, Medicine, Infusions, Intravenou, 030212 general & internal medicine, Child, Aged, Least-Squares Analysi, business.industry, Cholesterol, Homozygote, Antibodies, Monoclonal, Cholesterol, LDL, General Medicine, Middle Aged, medicine.disease, Endocrinology, Receptors, LDL, Multicenter study, chemistry, Ldl metabolism, Mutation, Female, lipids (amino acids, peptides, and proteins), business, Human, Lipoprotein
Abstract

BACKGROUND: Homozygous familial hypercholesterolemia is characterized by premature cardiovascular disease caused by markedly elevated levels of low-density lipoprotein (LDL) cholesterol. This disorder is associated with genetic variants that result in virtually absent (null-null) or impaired (non-null) LDL-receptor activity. Loss-of-function variants in the gene encoding angiopoietin-like 3 (ANGPTL3) are associated with hypolipidemia and protection against atherosclerotic cardiovascular disease. Evinacumab, a monoclonal antibody against ANGPTL3, has shown potential benefit in patients with homozygous familial hypercholesterolemia. METHODS: In this double-blind, placebo-controlled, phase 3 trial, we randomly assigned in a 2:1 ratio 65 patients with homozygous familial hypercholesterolemia who were receiving stable lipid-lowering therapy to receive an intravenous infusion of evinacumab (at a dose of 15 mg per kilogram of body weight) every 4 weeks or placebo. The primary outcome was the percent change from baseline in the LDL cholesterol level at week 24. RESULTS: The mean baseline LDL cholesterol level in the two groups was 255.1 mg per deciliter, despite the receipt of maximum doses of background lipid-lowering therapy. At week 24, patients in the evinacumab group had a relative reduction from baseline in the LDL cholesterol level of 47.1%, as compared with an increase of 1.9% in the placebo group, for a between-group least-squares mean difference of -49.0 percentage points (95% confidence interval [CI], -65.0 to -33.1; P

Published
2020

3. Images in clinical medicine. Swinging heart.

Author

Akkerhuis JM and Hersbach FM

Subjects
Carcinoma, Small Cell complications, Echocardiography, Humans, Lung Neoplasms complications, Male, Middle Aged, Pericardial Effusion etiology, Pericardial Effusion physiopathology, Pericardiocentesis, Tachycardia diagnosis, Tachycardia etiology, Electrocardiography, Heart physiopathology, Pericardial Effusion diagnostic imaging
Published
2004
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