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In this present work, we report the synthesis and structural characterization of a trinuclear Zn(II) complex [{ZnL(N3)}2Zn]·H2O (1), which was derived from a bi-compartmental (N2O4) Schiff base ligand (H2L), synthesized by the 1 : 2 condensation of 1,4-butanediamine and 3-ethoxysalicylaldehyde. The complex was characterized using elemental analysis, IR and UV-Vis spectroscopies, 1H-NMR and single crystal X-ray diffraction studies. The antimicrobial properties of the complex have been investigated. The growing incidence of microbial resistance to available pharmaceuticals has become a major global health concern. The rationale of the study is to evaluate the antibacterial and antibiofilm activities and probable mechanism of action of the novel trinuclear zinc(II) complex. The extent of antibacterial activity was evaluated using the minimal bactericidal concentration method. The anti-biofilm potential of the compound was evaluated using the crystal violet assay and fluorescence microscopy. Radioactively labeled N-acetyl glucosamine, leucine, thymidine, and uridine were used to evaluate the effect of the zinc compound on the cell wall, protein, DNA, and RNA biosynthesis. Our zinc complex showed potential antibacterial activity against most of the tested bacterial samples with a maximum sensitivity against Pseudomonas aeruginosa. The zinc compound dependent inhibition of DNA synthesis and biofilm formation was found in Pseudomonas aeruginosa. Considering the results, we are proposing our novel zinc compound as a promising candidate for the development of antibacterial drugs.

In this work, we report a distorted square pyramidal mononuclear copper(II) complex [Cu(L)(N3)] (1), which was synthesized from a tetradentate Schiff base (HL), prepared by the condensation of salicylaldehyde and N-2-(aminoethyl)-1,3-propanediamine. Complex 1 has been successfully characterized based on elemental analysis, IR spectroscopy, UV-Vis spectroscopy, ESI-MS, PXRD and FESEM. The structure of the complex is confirmed using a single-crystal X-ray diffraction study. The DFT, molecular dynamics and solid-state quantum mechanical calculations of the DOS of the compound are also studied. Annealing of complex 1 at 320, 340 and 360 K considering the Al-1-Al planar structure confirms the gradual decrease in electrical conductivity. The current–voltage characteristics of the Al-1-ITO planar structure are studied using the thermionic emission model of the Schottky barrier diode and the device parameters are estimated using the conventional method. The DFT, molecular dynamics and solid-state quantum mechanical calculations of the DOS of complex 1 are also studied. In addition, we explore the protein interaction ability of the complex with bovine serum albumin (BSA) with the help of spectroscopy and docking studies.

An azido bridged dinuclear complex [Cu(L−)(μ1,1N3)]2 (1) was synthesized by a 1 : 1 condensation of N-cyclohexyl-1,3-propanediamine and 5-bromosalicylaldehyde (HL). The complex was subsequently characterized based on elemental analyses, IR, single-crystal X-ray diffraction, a Hirshfeld study, FESEM, ESI-MS, powder XRD and also DFT studies successfully. The X-ray crystal structure of complex 1 revealed that the Cu(II) ion exhibited a definite five-coordinate square pyramidal coordination arrangement with a centro-symmetric μ 1,1-azido bridging in the end-on mode and formed a dimeric structure. The optical direct band gap of complex 1 was estimated to be 2.84 eV. The current–voltage characteristics of the Al/1/ITO structure were analyzed considering the thermionic emission theory of the Schottky barrier diode. The transient behaviour of the test structure was found to be interesting as it showed explicit frequency-selective phenomena. In view of an application-specific perspective for the material, compound 1 can be exploited as an electronic material for the development of electronic filters.