1. Fabrication of innovative ZnO nanoflowers showing drastic biological activity
- Author
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Shaikh M. Mobin, Archana Chaudhary, Kshipra Kapoor, Vinay Sharma, Akbar Mohammad, and Veenu Mishra
- Subjects
pBluescript ,biology ,Chemistry ,Nanotechnology ,Biological activity ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,biology.organism_classification ,Cleavage (embryo) ,01 natural sciences ,Combinatorial chemistry ,Catalysis ,0104 chemical sciences ,chemistry.chemical_compound ,Escherichia ,Materials Chemistry ,0210 nano-technology ,Oxidative cleavage ,Bacteria ,DNA ,Strong binding - Abstract
The present study deals with the synthesis of ZnO nanoflowers (ZnO-1 and ZnO-2) at room temperature using new structurally characterized single molecular precursors (1 and 2). 1, 2 and ZnO-1 were explored for their potential to reduce the viability of the Gram-negative bacteria Escherichia coli.1 and 2 were found to be promising antibacterial agents, while the ZnO nanoflowers demonstrated a relatively non-toxic nature. 1, 2 and ZnO-1 were further evaluated for DNA binding and cleavage behaviour. 1 and 2 showed strong binding affinity towards CT-DNA compared to ZnO-1. In addition, all the three compounds demonstrated oxidative cleavage of pBluescript plasmid DNA in the presence of H2O2.
- Published
- 2016
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