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Your search keyword '"M Bessho"' showing total 8 results
Start Over Author "M Bessho" Journal nihon ketsueki gakkai zasshi journal of japan haematological society
8 results on '"M Bessho"'

1. Hemopoietic stem cell kinetics in mice bearing CSF-producing fibrosarcoma.

Author

Bessho M, Hirashima K, Ando K, Nara N, and Momoi H

Subjects
Animals, Bone Marrow pathology, Female, Fibrosarcoma metabolism, Granulocytes pathology, Kinetics, Leukocyte Count, Mice, Mice, Inbred C3H, Sarcoma, Experimental metabolism, Sarcoma, Experimental pathology, Spleen pathology, Tumor Stem Cell Assay, Colony-Stimulating Factors biosynthesis, Fibrosarcoma pathology, Hematopoietic Stem Cells pathology
Published
1984

5. Effects on human bone marrow cells of colony-stimulating factors produced in large quantities from the conditioned medium of thyroid cancer cells.

Author

Bessho M, Hirashima K, Nomura H, Ono M, Okabe T, Ohsawa N, Nara N, and Momoi H

Subjects
Animals, Cells, Cultured, Colony-Stimulating Factors pharmacology, Humans, Lipoproteins biosynthesis, Lipoproteins pharmacology, Mice, Neutrophils drug effects, Thyroid Neoplasms pathology, Bone Marrow Cells, Colony-Stimulating Factors biosynthesis, Proteins
Published
1984

6. Effects of recombinant human G-CSF and GM-CSF on primary human leukemic cells.

Author

Itoh K, Bessho M, and Hirashima K

Subjects
Acute Disease, Granulocyte Colony-Stimulating Factor, Granulocyte-Macrophage Colony-Stimulating Factor, Humans, Recombinant Proteins pharmacology, Tumor Cells, Cultured, Tumor Stem Cell Assay, Colony-Stimulating Factors pharmacology, Growth Substances pharmacology, Leukemia, Myeloid drug therapy, Precursor Cell Lymphoblastic Leukemia-Lymphoma drug therapy
Abstract

The effects of recombinant human granulocyte colony-stimulating factor (rhG-CSF) and recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) on primary human leukemic cells were studied. Phagocyte-depleted mononuclear cells containing more than 88% blasts were obtained from peripheral blood of 11 AML and 2 ALL patients and from bone marrow aspirates from 2 ALL patients. The leukemic cells were incubated with these CSF in suspension cultures or in methylcellulose cultures. In suspension cultures, the spontaneous proliferation was observed in 1 M4 patient. RhG-CSF stimulated the leukemic cell proliferation in 5 AML, cases and rhGM-CSF that in 4 AML cases. In methylcellulose cultures, spontaneous colony formation occurred in 3 M4 patients. RhG-CSF and rhGM-CSF stimulated the leukemic colony formation in 8 AML cases. The CSFs had an additive effect in both cultures. Neither CSF induced O2- production or phagocytic activity. From these results, we concluded that both CSFs stimulated the proliferation of leukemic cells without inducing differentiation.

Published
1989

8. [Relationship of bone marrow dose to eosinophilia following radiotherapy: a study of patients with breast, lung, cervical, and ovarian cancer].

Author

Murohashi I, Gomi H, Nakano T, Morita S, Arai T, Jinnai I, Nara N, Bessho M, and Hirashima K

Subjects
Adult, Aged, Dose-Response Relationship, Radiation, Female, Hematopoiesis radiation effects, Humans, Leukocyte Count, Middle Aged, Radiotherapy Dosage, Bone Marrow radiation effects, Breast Neoplasms radiotherapy, Eosinophilia etiology, Lung Neoplasms radiotherapy, Ovarian Neoplasms radiotherapy, Radiotherapy adverse effects, Uterine Cervical Neoplasms radiotherapy
Published
1986

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