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Your search keyword '"Receptors, Interleukin-6 physiology"' showing total 6 results
Start Over Descriptor "Receptors, Interleukin-6 physiology" Journal nihon rinsho japanese journal of clinical medicine
6 results on '"Receptors, Interleukin-6 physiology"'

1. [IL-6 signal transduction and its physiological roles].

Author

Murakami M, Arima Y, and Hirano T

Subjects
Animals, Arthritis, Rheumatoid drug therapy, Arthritis, Rheumatoid immunology, Arthritis, Rheumatoid metabolism, Humans, Janus Kinases physiology, Mice, Receptors, Interleukin-6 physiology, STAT3 Transcription Factor physiology, Suppressor of Cytokine Signaling 3 Protein, Suppressor of Cytokine Signaling Proteins physiology, Interleukin-6 physiology, Signal Transduction physiology
Published
2012

2. [Interleukin-6 (IL-6) /soluble IL-6 receptor].

Author

Yokoyama A

Subjects
Biomarkers blood, Central Nervous System Diseases diagnosis, Collagen Diseases diagnosis, Enzyme-Linked Immunosorbent Assay, Heart Diseases diagnosis, Humans, Interleukin-6 physiology, Neoplasms diagnosis, Receptors, Interleukin-6 physiology, Reference Values, Respiratory Tract Diseases diagnosis, Specimen Handling, Stress, Physiological diagnosis, Interleukin-6 blood, Receptors, Interleukin-6 blood
Published
2005

3. [Anti-IL-6 receptor antibody].

Author

Nishimoto N

Subjects
Antibodies, Monoclonal, Humanized, Arthritis, Juvenile drug therapy, Arthritis, Juvenile etiology, Arthritis, Rheumatoid drug therapy, Arthritis, Rheumatoid etiology, Castleman Disease drug therapy, Castleman Disease etiology, Crohn Disease drug therapy, Crohn Disease etiology, Humans, Interleukin-6 physiology, Randomized Controlled Trials as Topic, Receptors, Interleukin-6 physiology, Still's Disease, Adult-Onset drug therapy, Still's Disease, Adult-Onset etiology, Antibodies, Monoclonal pharmacology, Antibodies, Monoclonal physiology, Antibodies, Monoclonal therapeutic use, Receptors, Interleukin-6 immunology
Published
2005

4. [Interleukin-6 in pathogenesis of rheumatoid arthritis].

Author

Mihara M and Nishimoto N

Subjects
Animals, Antibodies, Monoclonal therapeutic use, Antigens, CD physiology, Antirheumatic Agents therapeutic use, Autoantibodies, B-Lymphocytes immunology, Cell Differentiation, Collagen metabolism, Cytokine Receptor gp130, Disease Models, Animal, Drug Design, Humans, Interleukin-6 immunology, Membrane Glycoproteins physiology, Osteoclasts cytology, Receptors, Interleukin-6 genetics, Receptors, Interleukin-6 physiology, Signal Transduction genetics, Signal Transduction physiology, Arthritis, Rheumatoid etiology, Inflammation Mediators, Interleukin-6 physiology
Published
2005

5. [Glucocorticoid-induced osteoporosis in patients with rheumatoid arthritis and collagen diseases].

Author

Sohen S

Subjects
Antibodies, Monoclonal therapeutic use, Antirheumatic Agents therapeutic use, Arthritis, Rheumatoid drug therapy, Bone Resorption diagnosis, Bone Resorption drug therapy, Collagen Diseases drug therapy, Cytokines physiology, Diphosphonates therapeutic use, Glycoproteins physiology, Humans, Inflammation Mediators physiology, Interleukin 1 Receptor Antagonist Protein, Osteoprotegerin, Receptors, Cytoplasmic and Nuclear physiology, Receptors, Interleukin-1 antagonists & inhibitors, Receptors, Interleukin-1 physiology, Receptors, Interleukin-6 antagonists & inhibitors, Receptors, Interleukin-6 physiology, Receptors, Tumor Necrosis Factor, Recombinant Proteins therapeutic use, Sialoglycoproteins therapeutic use, Tumor Necrosis Factor-alpha immunology, Arthritis, Rheumatoid complications, Bone Resorption etiology, Collagen Diseases complications, Prednisolone adverse effects
Published
2004

6. [Analysis of cytokine receptor function by gene manipulation].

Author

Taga T

Subjects
Animals, Antigens, CD physiology, Cytokines physiology, Membrane Glycoproteins physiology, Mice, Mice, Knockout, Mice, Transgenic, Receptors, Cytokine genetics, Receptors, Interleukin-6 physiology, Signal Transduction, Genetic Engineering, Receptors, Cytokine physiology
Abstract

As a tool to investigate physiological and pathological roles of cytokines, gene manipulation techniques have been applied to make mouse models having mutations in cytokine receptor genes. Functional pleiotropy and redundancy are two major characteristic features of cytokines. The latter feature is in part explained by the shared usage of a signal-transducing receptor component by several cytokine receptor complexes. In this article, studies with the help of gene manipulation techniques on a group of cytokine receptor complexes sharing the signal transducer, gp130, are reviewed. To investigate the in vivo roles of gp130, mice deficient for gp130 or having constitutively activated gp130 were made. Transgenic mice expressing a dominant-negative form of gp130 were produced as well. Observation from these mouse models and that from mice deficient for other gp130-related receptors and ligans are also reviewed in this article.

Published
1998

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