1. Proton-induced production and radiochemical isolation of 44 Ti from scandium metal targets for 44 Ti/ 44 Sc generator development.
- Author
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Radchenko V, Engle JW, Medvedev DG, Maassen JM, Naranjo CM, Unc GA, Meyer CAL, Mastren T, Brugh M, Mausner L, Cutler CS, Birnbaum ER, John KD, Nortier FM, and Fassbender ME
- Subjects
- Gamma Rays, Radiochemistry instrumentation, Protons, Radiochemistry methods, Radioisotopes chemistry, Radioisotopes isolation & purification, Scandium chemistry, Titanium chemistry, Titanium isolation & purification
- Abstract
Scandium-44g (half-life 3.97h) shows promise for application in positron emission tomography (PET), due to favorable decay parameters. One of the sources of
44g Sc is the44 Ti/44g Sc generator, which can conveniently provide this radioisotope on a daily basis at a diagnostic facility. Titanium-44 (half-life 60.0 a), in turn, can be obtained via proton irradiation of scandium metal targets. A substantial44 Ti product batch, however, requires high beam currents, long irradiation times and an elaborate chemical procedure for44 Ti isolation and purification. This study describes the production of a combined 175MBq (4.7mCi) batch yield of44 Ti in week long proton irradiations at the Los Alamos Isotope Production Facility (LANL-IPF) and the Brookhaven Linac Isotope Producer (BNL-BLIP). A two-step ion exchange chromatography based chemical separation method is introduced: first, a coarse separation of44 Ti via anion exchange sorption in concentrated HCl results in a44 Tc/Sc separation factor of 102 -103 . A second, cation exchange based step in HCl media is then applied for44 Ti fine purification from residual Sc mass. In summary, this method yields a 90-97%44 Ti recovery with an overall Ti/Sc separation factor of ≥106 ., (Copyright © 2017 Elsevier Inc. All rights reserved.)- Published
- 2017
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