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Start Over Author "Choi, Joon Young" Journal nuclear medicine and molecular imaging
20 results on '"Choi, Joon Young"'

20. Usefulness of 99m Tc-SESTAMIBI Scintigraphy in Persistent Hyperparathyroidism after Kidney Transplant.

Author

Shin M, Choi JY, Kim SW, Kim JH, and Cho YS

Abstract

Purpose: 99m Tc-labeled sestamibi scintigraphy combined with single-photon emission computed tomography (SPECT) has a high positive predictive value for localizing hyperfunctioning parathyroid lesions in primary hyperparathyroidism (pHPT) but relatively low sensitivity and specificity in secondary hyperparathyroidism (sHPT) and tertiary hyperparathyroidism (tHPT). The purpose of this study is to investigate the usefulness of 99m Tc-sestamibi scintigraphy in persistent hyperparathyroidism after kidney transplant (KT)., Methods: Retrospectively evaluated 50 patients who received parathyroidectomy after KT at a single medical center. The parathyroid lesion with the highest sestamibi uptake intensity of a patient was graded from 0 to 3. Uptake intensity was analyzed in correlation with parathyroid hormone (PTH), calcium, ionized calcium, phosphorus, and vitamin D., Results: Per-patient analysis, 43 patients had hyperplasia, 6 patients had adenomas, and 1 patient had a carcinoma. Only 3 patients with hyperplasia did not demonstrate any sestamibi uptake in the parathyroid scans. Out of the 148 pathologically confirmed parathyroid lesions, SPECT/CT images were able to identify 89 lesions (60%) and planar images of 71 lesions (48%). The average of sestamibi uptake intensity was mild at grade 1.6. Uptake intensity showed a positive correlation with parathyroid hormone (PTH) level but not with phosphorus, calcium, ionized calcium, or vitamin D levels. The largest lesion showed a high positive predictive value, especially in lesions with a diameter over 1.0 cm., Conclusions: Regardless of relatively low and less discrete uptake in KT patients, it well depicts the largest and the most hyperfunctioning lesion., Competing Interests: Conflict of InterestMuheon Shin, Joon Young Choi, Sun Wook Kim, Jung Han Kim, and Young Seok Cho declare no conflict of interest., (© Korean Society of Nuclear Medicine 2021.)

Published
2021
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