1. Radioprotective effect of vitamin E on salivary glands after radioiodine therapy for differentiated thyroid cancer: a randomized-controlled trial
- Author
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Peng Wang, Ziyu Yan, Xuemeng Zhang, Zhaowei Meng, Fengxiao Zhao, Tianpeng Hu, Xue Li, Arun Upadhyaya, Guizhi Zhang, Xiaoran Wang, Huiying Wang, Na Liu, Xiaoxia Liu, Sen Wang, Jian Tan, Chunmei Zhang, Qiang Jia, Wan Zhang, and Pingping Zhou
- Subjects
Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Radiation-Protective Agents ,Group A ,Gastroenterology ,Group B ,Salivary Glands ,030218 nuclear medicine & medical imaging ,law.invention ,Excretion ,Iodine Radioisotopes ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,stomatognathic system ,Randomized controlled trial ,law ,Internal medicine ,medicine ,Humans ,Vitamin E ,Radiology, Nuclear Medicine and imaging ,Thyroid Neoplasms ,Thyroid cancer ,Salivary gland ,business.industry ,Radioiodine therapy ,General Medicine ,Middle Aged ,medicine.disease ,stomatognathic diseases ,Endocrinology ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Female ,business - Abstract
OBJECTIVES This study aimed to examine the radioprotective effect of vitamin E on salivary glands after radioactive iodine (I) therapy in patients with differentiated thyroid cancer. PATIENTS AND METHODS Eighty-two patients with differentiated thyroid cancer were enrolled in this study. They were divided randomly into four groups (control group: 22 cases, group A: 23 cases, group B: 22 cases, and group C: 15 cases) before postsurgical ablation therapy with 100 mCi I. The patients in groups A, B, and C received vitamin E 100, 200, and 300 mg/day orally, respectively, for a duration of 1 week before to 4 weeks after I therapy. Salivary gland function was assessed using salivary gland scintigraphy immediately before and 6 months after I therapy. Uptake fraction (UF), uptake index (UI), excretion fraction (EF), and excretion ratio (ER) of each salivary gland were measured and compared. RESULTS On comparison between before and after I therapy in the control group, there was a significant decrease in UF of both right and left parotid glands (all P
- Published
- 2017