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Your search keyword '"Wood, Matthew"' showing total 13 results
Start Over Author "Wood, Matthew" Journal nucleic acids research
13 results on '"Wood, Matthew"'

1. Control of backbone chemistry and chirality boost oligonucleotide splice switching activity

Author

Kandasamy, Pachamuthu, primary, McClorey, Graham, additional, Shimizu, Mamoru, additional, Kothari, Nayantara, additional, Alam, Rowshon, additional, Iwamoto, Naoki, additional, Kumarasamy, Jayakanthan, additional, Bommineni, Gopal R, additional, Bezigian, Adam, additional, Chivatakarn, Onanong, additional, Butler, David C D, additional, Byrne, Michael, additional, Chwalenia, Katarzyna, additional, Davies, Kay E, additional, Desai, Jigar, additional, Shelke, Juili Dilip, additional, Durbin, Ann F, additional, Ellerington, Ruth, additional, Edwards, Ben, additional, Godfrey, Jack, additional, Hoss, Andrew, additional, Liu, Fangjun, additional, Longo, Kenneth, additional, Lu, Genliang, additional, Marappan, Subramanian, additional, Oieni, Jacopo, additional, Paik, Ik-Hyeon, additional, Estabrook, Erin Purcell, additional, Shivalila, Chikdu, additional, Tischbein, Maeve, additional, Kawamoto, Tomomi, additional, Rinaldi, Carlo, additional, Rajão-Saraiva, Joana, additional, Tripathi, Snehlata, additional, Yang, Hailin, additional, Yin, Yuan, additional, Zhao, Xiansi, additional, Zhou, Cong, additional, Zhang, Jason, additional, Apponi, Luciano, additional, Wood, Matthew J A, additional, and Vargeese, Chandra, additional

Published
2022
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11. PepFect 14, a novel cell-penetrating peptide for oligonucleotide delivery in solution and as solid formulation

Author

Ezzat, Kariem, primary, EL Andaloussi, Samir, additional, Zaghloul, Eman M., additional, Lehto, Taavi, additional, Lindberg, Staffan, additional, Moreno, Pedro M. D., additional, Viola, Joana R., additional, Magdy, Tarek, additional, Abdo, Rania, additional, Guterstam, Peter, additional, Sillard, Rannar, additional, Hammond, Suzan M., additional, Wood, Matthew J. A., additional, Arzumanov, Andrey A., additional, Gait, Michael J., additional, Smith, C. I. Edvard, additional, Hällbrink, Mattias, additional, and Langel, Ülo, additional

Published
2011
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13. A RAD18-UBC13-PALB2-RNF168 axis mediates replication fork recovery in BRCA1-deficient cancer cells.

Author

Cybulla E, Wallace S, Meroni A, Jackson J, Agashe S, Tennakoon M, Limbu M, Quinet A, Lomonosova E, Noia H, Tirman S, Wood M, Lemacon D, Fuh K, Zou L, and Vindigni A

Abstract

BRCA1/2 proteins function in genome stability by promoting repair of double-stranded DNA breaks through homologous recombination and by protecting stalled replication forks from nucleolytic degradation. In BRCA1/2-deficient cancer cells, extensively degraded replication forks can be rescued through distinct fork recovery mechanisms that also promote cell survival. Here, we identified a novel pathway mediated by the E3 ubiquitin ligase RAD18, the E2-conjugating enzyme UBC13, the recombination factor PALB2, the E3 ubiquitin ligase RNF168 and PCNA ubiquitination that promotes fork recovery in BRCA1- but not BRCA2-deficient cells. We show that this pathway does not promote fork recovery by preventing replication fork reversal and degradation in BRCA1-deficient cells. We propose a mechanism whereby the RAD18-UBC13-PALB2-RNF168 axis facilitates resumption of DNA synthesis by promoting re-annealing of the complementary single-stranded template strands of the extensively degraded forks, thereby allowing re-establishment of a functional replication fork. We also provide preliminary evidence for the potential clinical relevance of this novel fork recovery pathway in BRCA1-mutated cancers, as RAD18 is over-expressed in BRCA1-deficient cancers, and RAD18 loss compromises cell viability in BRCA1-deficient cancer cells., (© The Author(s) 2024. Published by Oxford University Press on behalf of Nucleic Acids Research.)

Published
2024
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