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Start Over Topic adenine Journal nucleic acids symposium series

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1. Synthesis and antiviral activities of 9-cyclopentylpurine derivatives.

Author

Kojima E, Ohta K, Miyawaki S, Date T, Machida M, and Murakami K

Subjects
Adenine chemical synthesis, Animals, Antiviral Agents chemistry, Avian Sarcoma Viruses drug effects, Chick Embryo, Drug Evaluation, Preclinical, Fibroblasts, HIV-1 drug effects, In Vitro Techniques, Stereoisomerism, Structure-Activity Relationship, Adenine analogs & derivatives, Adenine pharmacology, Antiviral Agents chemical synthesis, Antiviral Agents pharmacology
Abstract

The synthesis and anti-RSV (Rouse Sarcoma Virus) activity of HMCA, (+/-)-9-(2-hydroxymethyl-cyclopenthyl)-adenine, and its derivatives are described. It has been demonstrated that trans-HMCA has greater anti-RSV activity in tissue culture than cis-HMCA.

Published
1995