Background/Purpose: Asthma is a prevalent chronic condition with excess disease burden in school-aged, minority children from low income inner-city communities. Conceptualized within a nursing and socio-ecological framework, the purpose of this secondary analysis of inner-city school-aged children with asthma was to quantify how parental characteristics and local environment affect stress and health knowledge that, in turn, encourage or discourage better parent asthma management behaviors (AMB). Theoretical Framework: Dorothea Orem's Self-Care Framework and Albert Bandura's Social Cognitive Theory were used. Methods: A prospective, correlational study with a longitudinal design of inner-city, school-aged children with asthma was conducted. The sample included 351 school-aged children (7.9 years old, SD= 1.9 years; 53.0% male; 95.7% minority). Parents reported race, education, income, stress, housing, family and neighborhood characteristics, as well as AMBs (including medication administration, routine healthcare visits, smoke and pest exposure) at baseline. Smoke and pest exposure was also measured at four follow-up points every 3 months. Logistic regression was used for each AMB model. Logistic generalized estimation regression was used for children's smoke and pest exposure due to the repeated quarterly wave nature of the data. Results: Controlling for demographics and inner-city characteristics, parents with high stress were more likely to have children with passive smoke exposure (OR=1.6, p=.04) and miss healthcare appointments (OR=5.2, p=.05). Parents who missed their child's healthcare appointments and have pests in their home were both more likely to live in an unmaintained neighborhood (OR=7.6, p=.001; OR=1.8, p=.002) and have more family members in their home (OR=5.0, p=.01; OR=2.0, p=.000). Lastly, parents with asthma knowledge were more likely to administer medications regularly (OR=15.2, p=.01). Conclusions/Implications: Parents with high stress and who reside with large families in unmaintained neighborhoods are at higher risk for not performing AMBs that support the best outcomes for their child with asthma. Implementation of nationally recommended, evidence-based interventions for child homes and parent education of asthma through transdisci-plinary healthcare providers for this inner-city population are needed. Research on the implementation science of these interventions and role of parent stress on the effectiveness of these interventions in the inner-city population is necessary. [ABSTRACT FROM AUTHOR]