1. Efecto del aceite de pescado en la actividad hidrolítica de la ATPasa y en la fluidez de la membrana mitocondrial en pacientes con esclerosis múltiple remitente-recurrente tratados con interferón beta 1-b.
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Torres-Sánchez, Erandis D., Pacheco-Moisés, Fermín P., Macias-Islas, Miguel A., Morales-Sánchez, Eddic W., Ramírez-Ramírez, Viridiana, de la Rosa, Alfredo J. Celis, Cid-Hernández, Margarita, Sorto-Gómez, Tanya E., Ortiz, Genaro G., and Celis de la Rosa, Alfredo J
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ADENOSINE triphosphatase , *FISH oils , *OLIVE oil , *INTERFERON beta 1b , *MULTIPLE sclerosis , *PATIENTS , *THERAPEUTICS , *THERAPEUTIC use of amino acids , *NEUROPROTECTIVE agents , *CEREBRAL ischemia , *COMPARATIVE studies , *RESEARCH methodology , *MEDICAL cooperation , *RESEARCH , *STATISTICAL sampling , *STROKE , *EVALUATION research , *RANDOMIZED controlled trials , *TREATMENT effectiveness - Abstract
Background: Multiple sclerosis (MS) is an inflammatory disease of the central nervous system associated with increased oxidative stress (OS) and mitochondrial alterations. Fish oil consumption has neuroprotective, antioxidant and anti-inflammatory effects in patients with relapsing-recurrent MS (RR-MS).Objective: To evaluate changes in the hydrolytic activity of ATP synthase and mitochondrial membrane fluidity in patients with RR-MS who receive fish oil or olive oil as a dietary supplement.Methods: Clinical, controlled, randomized, double-blind trial. Patients consumed fish oil or olive oil for one year. The hydrolytic activity of ATPase and the fluidity of the mitochondrial membrane of platelets were quantified.Results: In patients with RR-MS, a decrease in the fluidity of mitochondrial membranes and an increase in the hydrolytic activity of ATP synthase was observed in comparison with healthy controls. After 6 or 9 months of treatment with fish oil or olive oil, respectively, these values were normalized.Conclusion: The consumption of fish oil and olive oil increases the fluidity of the mitochondrial membranes and decreases the catabolic activity of ATP synthase in platelets from patients with RR-MS. [ABSTRACT FROM AUTHOR]- Published
- 2018
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