1. Prenatal Exposure to BPA: The Effects on Hepatic Lipid Metabolism in Male and Female Rat Fetuses
- Author
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Alessandro Leone, Marco Segatto, Simona Bertoli, Arianna Mazzoli, Luisa Cigliano, Valentina Pallottini, Claudia Tonini, Maurizio Mandalà, Laura Barberio, Tonini, C., Segatto, M., Bertoli, S., Leone, A., Mazzoli, A., Cigliano, L., Barberio, L., Mandala, M., Pallottini, V., Tonini, Claudia, Segatto, Marco, Bertoli, Simona, Leone, Alessandro, Mazzoli, Arianna, Cigliano, Luisa, Barberio, Laura, Mandalà, Maurizio, and Pallottini, Valentina
- Subjects
0301 basic medicine ,Male ,Chemical compound ,bisphenol A ,010501 environmental sciences ,01 natural sciences ,Rats, Sprague-Dawley ,chemistry.chemical_compound ,Bisphenol A ,Pregnancy ,TX341-641 ,Fetu ,3-hydroxy 3-methylglutaryl coenzyme A reductase, acyl coenzyme A carboxylase, bisphenol A, cholesterol, fatty acids, fetuses, liver ,Benzhydryl Compound ,Nutrition and Dietetics ,Fetuse ,Lipid ,Lipids ,Cholesterol ,Liver ,In utero ,Prenatal Exposure Delayed Effects ,Female ,hormones, hormone substitutes, and hormone antagonists ,medicine.medical_specialty ,endocrine system ,Offspring ,Acyl coenzyme A carboxylase ,liver ,fatty acids ,Prenatal Exposure Delayed Effect ,Article ,3-hydroxy 3-methylglutaryl coenzyme A reductase ,Fatty acids ,Fetuses ,Animals ,Benzhydryl Compounds ,Estrogen Receptor alpha ,Fetus ,Inflammation ,Lipid Metabolism ,Phenols ,03 medical and health sciences ,Internal medicine ,medicine ,Prenatal exposure ,0105 earth and related environmental sciences ,Phenol ,Nutrition. Foods and food supply ,business.industry ,Animal ,urogenital system ,cholesterol ,Metabolism ,Fatty acid ,Rats ,030104 developmental biology ,Endocrinology ,chemistry ,Hepatic lipid ,fetuses ,acyl coenzyme A carboxylase ,Sprague-Dawley ,business ,Food Science - Abstract
Bisphenol A (BPA) is an organic chemical compound widely used for manufacturing plastics. BPA exposure originates principally from the diet, but it can also originate from dermal contact. In over 90% of individuals, including pregnant women, BPA is detectable in several body fluids. The effects of this exposure on the fetus are under active investigation in several research laboratories. The aim of our work was to study the impact of prenatal exposure to BPA in the liver of rat fetuses from a sex-dependent point of view. We particularly investigated the effects of prenatal BPA exposure on hepatic lipids because of their crucial role, not only for the liver, but also for the whole-body functions. Our results demonstrate that the liver of rat fetuses, in utero exposed to a very low dose of BPA (2.5 µg/kg/day), displays significant modulations with regard to proteins involved in cholesterol and fatty acid biosynthesis and trafficking. Moreover, an impact on inflammatory process has been observed. All these effects are dependent on sex, being observable only in female rat fetuses. In conclusion, this work demonstrates that maternal exposure to BPA compromises hepatic lipid metabolism in female offspring, and it also reveals the perspective impact of BPA on human health at doses currently considered safe.
- Published
- 2021