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1. Yoghurt Intake and Gastric Cancer: A Pooled Analysis of 16 Studies of the StoP Consortium

Author: Collatuzzo, Giulia, Negri, Eva, Pelucchi, Claudio, Bonzi, Rossella, Turati, Federica, Rabkin, Charles S, Liao, Linda M, Sinha, Rashmi, Palli, Domenico, Ferraroni, Monica, López-Carrillo, Lizbeth, Lunet, Nuno, Morais, Samantha, Albanes, Demetrius, Weinstein, Stephanie J, Parisi, Dominick, Zaridze, David, Maximovitch, Dmitry, Dierssen-Sotos, Trinidad, Jiménez-Moleón, José Juan, Vioque, Jesus, de la Hera, Manoli Garcia, Curado, Maria Paula, Dias-Neto, Emmanuel, Hernández-Ramírez, Raúl Ulises, López-Cervantes, Malaquias, Ward, Mary H, Tsugane, Shoichiro, Hidaka, Akihisa, Lagiou, Areti, Lagiou, Pagona, Zhang, Zuo-Feng, Trichopoulou, Antonia, Karakatsani, Anna, Camargo, Maria Constanza, La Vecchia, Carlo, and Boffetta, Paolo
Subjects: Epidemiology, Biomedical and Clinical Sciences, Health Sciences, Cancer, Digestive Diseases, Oral and gastrointestinal, Male, Humans, Female, Stomach Neoplasms, Case-Control Studies, Logistic Models, Adenocarcinoma, Helicobacter Infections, Risk Factors, gastric cancer, diet, nutrition, yoghurt, Food Sciences, Nutrition and Dietetics, Clinical sciences, Nutrition and dietetics, Public health
Abstract: BackgroundYoghurt can modify gastrointestinal disease risk, possibly acting on gut microbiota. Our study aimed at exploring the under-investigated association between yoghurt and gastric cancer (GC).MethodsWe pooled data from 16 studies from the Stomach Cancer Pooling (StoP) Project. Total yoghurt intake was derived from food frequency questionnaires. We calculated study-specific odds ratios (ORs) of GC and the corresponding 95% confidence intervals (CIs) for increasing categories of yoghurt consumption using univariate and multivariable unconditional logistic regression models. A two-stage analysis, with a meta-analysis of the pooled adjusted data, was conducted.ResultsThe analysis included 6278 GC cases and 14,181 controls, including 1179 cardia and 3463 non-cardia, 1191 diffuse and 1717 intestinal cases. The overall meta-analysis revealed no association between increasing portions of yoghurt intake (continuous) and GC (OR = 0.98, 95% CI = 0.94-1.02). When restricting to cohort studies, a borderline inverse relationship was found (OR = 0.93, 95% CI = 0.88-0.99). The adjusted and unadjusted OR were 0.92 (95% CI = 0.85-0.99) and 0.78 (95% CI = 0.73-0.84) for any vs. no yoghurt consumption and GC risk. The OR for 1 category of increase in yoghurt intake was 0.96 (95% CI = 0.91-1.02) for cardia, 1.03 (95% CI = 1.00-1.07) for non-cardia, 1.12 (95% CI = 1.07-1.19) for diffuse and 1.02 (95% CI = 0.97-1.06) for intestinal GC. No effect was seen within hospital-based and population-based studies, nor in men or women.ConclusionsWe found no association between yoghurt and GC in the main adjusted models, despite sensitivity analyses suggesting a protective effect. Additional studies should further address this association.
Published: 2023

2. Inverse Association between Dietary Iron Intake and Gastric Cancer: A Pooled Analysis of Case-Control Studies of the Stop Consortium

Author: Collatuzzo, Giulia, Teglia, Federica, Pelucchi, Claudio, Negri, Eva, Rabkin, Charles S, Liao, Linda M, Sinha, Rashmi, López-Carrillo, Lizbeth, Lunet, Nuno, Morais, Samantha, Aragonés, Nuria, Moreno, Victor, Vioque, Jesus, de la Hera, Manoli Garcia, Ward, Mary H, Malekzadeh, Reza, Pakseresht, Mohammadreza, Hernández-Ramírez, Raúl Ulises, López-Cervantes, Malaquias, Bonzi, Rossella, Dalmartello, Michela, Tsugane, Shoichiro, Hidaka, Akihisa, Camargo, M Constanza, Curado, Maria Paula, Zhang, Zuo-Feng, Zubair, Nadia, La Vecchia, Carlo, Shah, Shailja, and Boffetta, Paolo
Subjects: Biomedical and Clinical Sciences, Nutrition and Dietetics, Health Sciences, Nutrition, Cancer, Prevention, Digestive Diseases, Case-Control Studies, Diet, Humans, Iron, Iron, Dietary, Risk Factors, Stomach Neoplasms, gastric cancer, iron, diet, cancer subtypes, cancer subsites, Food Sciences, Clinical sciences, Nutrition and dietetics, Public health
Abstract: Background: Inconsistent findings have been reported regarding the relationship between dietary iron intake and the risk of gastric cancer (GC). Methods: We pooled data from 11 case-control studies from the Stomach Cancer Pooling (StoP) Project. Total dietary iron intake was derived from food frequency questionnaires combined with national nutritional tables. We derived the odds ratios (ORs) and 95% confidence intervals (CIs) for quartiles of dietary iron through multivariable unconditional logistic regression models. Secondary analyses stratified by sex, smoking status, caloric intake, anatomical subsite and histological type were performed. Results: Among 4658 cases and 12247 controls, dietary iron intake was inversely associated with GC (per quartile OR 0.88; 95% CI: 0.83-0.93). Results were similar between cardia (OR = 0.85, 95% CI = 0.77-0.94) and non-cardia GC (OR = 0.87, 95% CI = 0.81-0.94), and for diffuse (OR = 0.79, 95% CI = 0.69-0.89) and intestinal type (OR = 0.88, 95% CI = 0.79-0.98). Iron intake exerted an independent effect from that of smoking and salt intake. Additional adjustment by meat and fruit/vegetable intake did not alter the results. Conclusions: Dietary iron is inversely related to GC, with no difference by subsite or histological type. While the results should be interpreted with caution, they provide evidence against a direct effect of iron in gastric carcinogenesis.
Published: 2022

3. Validity of a Short Food Frequency Questionnaire for Toddlers of NELA Birth Cohort Study.

Author: Gonzalez-Palacios, Sandra, Ojeda-Belokon, Carolina, Oncina-Canovas, Alejandro, Compañ-Gabucio, Laura-María, Pastor-Fajardo, María-Teresa, Pérez, Adrian, Gázquez, Antonio, Larqué, Elvira, Morales, Eva, and Vioque, Jesús
Abstract: Background/Objectives: Our aim was to evaluate the reproducibility and validity of a semi-quantitative food frequency questionnaire (FFQ) for the assessment of usual nutrient and food intakes in children of 18 months old. Methods: We included 103 toddlers aged 18 months from the Nutrition in Early Life and Asthma (NELA) birth cohort study. A 47-item FFQ was administered twice to parents with a 3-month interval. During that period, we also performed three non-consecutive 24 h dietary recalls (24hDRs) and oral mucosa samples for determining the fatty acid profile (glycerophospholipids). We estimated correlation coefficients of reproducibility for nutrient and food group intakes by comparing both FFQs and validity coefficients by comparing nutrient intakes between the second FFQ and the average of the three 24hDRs. We also explored biochemical validity by comparing the intake of fish from the FFQ with the percentage of fatty acids in oral mucosa cells. Results: The average of correlation coefficients for FFQ reproducibility was r = 0.48 for energy-adjusted nutrient intakes (ranging from r = 0.28 for Na to r = 0.62 for Mg and Zn) and r = 0.35 for the intake of energy-adjusted food groups. The average correlation coefficient for FFQ validity on nutrient intakes was r = 0.48, ranging from r = 0.16 for α-carotene to r = 0.75 for vitamin E. We also found a positive correlation between total omega-3 fatty acids and docosahexaenoic acid percentages in oral mucosa cells and the intake of total and white fish, r = 0.31 and r = 0.34, respectively. Conclusions: This study shows that our short FFQ demonstrated moderate reproducibility (mean r = 0.48) and validity (mean r = 0.48) for dietary assessment of most nutrients and foods in 18-month-old children in Spain. This FFQ provides an efficient and minimally invasive method for evaluating toddler dietary intake, particularly in Mediterranean contexts. [ABSTRACT FROM AUTHOR]
Published: 2024
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4. Association between Beverage Consumption and Environmental Sustainability in an Adult Population with Metabolic Syndrome

Author: García, Silvia, primary, Monserrat-Mesquida, Margalida, additional, Argelich, Emma, additional, Ugarriza, Lucía, additional, Salas-Salvadó, Jordi, additional, Bautista, Inmaculada, additional, Vioque, Jesús, additional, Zomeño, María Dolores, additional, Corella, Dolores, additional, Pintó, Xavier, additional, Bueno-Cavanillas, Aurora, additional, Daimiel, Lidia, additional, Martínez, J. Alfredo, additional, Nishi, Stephanie, additional, Herrera-Ramos, Estefanía, additional, González-Palacios, Sandra, additional, Fitó, Montserrat, additional, Asensio, Eva M., additional, Fanlo-Maresma, Marta, additional, Cano-Ibáñez, Naomi, additional, Cuadrado-Soto, Esther, additional, Abete, Itziar, additional, Tur, Josep A., additional, and Bouzas, Cristina, additional
Published: 2024
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5. Objectively Measured Sleep Duration and Health-Related Quality of Life in Older Adults with Metabolic Syndrome: A One-Year Longitudinal Analysis of the PREDIMED-Plus Cohort.

Author: Marcos-Delgado, Alba, Martín-Sánchez, Vicente, Martínez-González, Miguel Ángel, Corella, Dolores, Salas-Salvadó, Jordi, Schröder, Helmut, Martínez, Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Vioque, Jesús, Romaguera, Dora, López-Miranda, José, Estruch, Ramon, Tinahones, Francisco J., Santos-Lozano, José M., Álvarez-Pérez, Jacqueline, Bueno-Cavanillas, Aurora, Cano-Ibáñez, Naomi, Amezcua-Prieto, Carmen, and Hernández-Segura, Natalia
Abstract: The aim of our cross-sectional and longitudinal study is to assess the relationship between daytime and night-time sleep duration and health-related quality of life (HRQoL) in adults with metabolic syndrome after a 1-year healthy lifestyle intervention. Analysis of the data from 2119 Spanish adults aged 55–75 years from the PREDIMED-Plus study was performed. Sleep duration was assessed using a wrist-worn accelerometer. HRQoL was measured using the SF-36 questionnaire. Linear regression models adjusted for socioeconomic and lifestyle factors and morbidity were developed. In cross-sectional analyses, participants with extreme night-time sleep duration categories showed lower physical component summary scores in Models 1 and 2 [β-coefficient (95% confidence interval) <6 h vs. 7–9 h: −2, 3 (−3.8 to −0.8); p = 0.002. >9 h vs. 7–9 h: −1.1 (−2.0 to −0.3); p = 0.01]. Participants who sleep less than 7 h a night and take a nap are associated with higher mental component summary scores [β-coefficient (95% confidence interval) 6.3 (1.3 to 11.3); p = 0.01]. No differences between night-time sleep categories and 12-month changes in HRQoL were observed. In conclusion, in cross-sectional analyses, extremes in nocturnal sleep duration are related to lower physical component summary scores and napping is associated with higher mental component summary scores in older adults who sleep less than 7 h a night. [ABSTRACT FROM AUTHOR]
Published: 2024
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6. Association between Coffee Consumption and Polycystic Ovary Syndrome: An Exploratory Case–Control Study.

Author: Meliani-Rodríguez, Aïcha, Cutillas-Tolín, Ana, Mendiola, Jaime, Sánchez-Ferrer, María Luisa, De la Cruz-Sánchez, Ernesto, Vioque, Jesús, and Torres-Cantero, Alberto M.
Abstract: Polycystic ovary syndrome (PCOS) is a leading cause of infertility, with an estimated worldwide prevalence between 5% and 15%. We conducted a case–control study with 121 PCOS patients and 155 controls to assess the association between coffee intake and the presence of having a diagnosis of PCOS in women in Murcia, Spain. The PCOS diagnosis was determined following Rotterdam criteria (the presence of two of the following three conditions: hyperandrogenism, oligo-anovulation, and/or polycystic ovarian morphology). Coffee consumption was assessed using a validated food frequency questionnaire. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using multiple logistic regression. Coffee consumption was categorized into never, less than one cup per day, one cup per day, and two or more cups per day. We found a significant inverse linear trend: the higher the coffee consumption, the lower the probability of having PCOS in multivariable analysis (p-trend = 0.034). Women who presented with PCOS were less likely to drink one cup of coffee compared to those who had never drunk coffee (OR = 0.313, 95% CI: 0.141–0.69). The consumption of at least one cup of coffee per day may be associated with a decrease in PCOS symptoms. [ABSTRACT FROM AUTHOR]
Published: 2024
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7. More Adult Women than Men at High Cardiometabolic Risk Reported Worse Lifestyles and Self-Reported Health Status in the COVID-19 Lockdown.

Author: Oncina-Cánovas, Alejandro, Compañ-Gabucio, Laura, Vioque, Jesús, Ruiz-Canela, Miguel, Corella, Dolores, Salas-Salvadó, Jordi, Fitó, Montserrat, Martínez, Alfredo, Alonso-Gómez, Ángel M., Wärnberg, Julia, Romaguera, Dora, López-Miranda, José, Estruch, Ramón, Tinahones, Francisco J., Lapetra, José, Álvarez-Pérez, Jacqueline, Bueno-Cavanillas, Aurora, Tur, Josep A., Martín-Sánchez, Vicente, and Esteve-Luque, Virginia
Abstract: Background: The COVID-19 lockdown represented an immense impact on human health, which was characterized by lifestyle and dietary changes, social distancing and isolation at home. Some evidence suggests that these consequences mainly affected women and altered relevant ongoing clinical trials. The aim of this study was to evaluate the status and changes in diet, physical activity (PA), sleep and self-reported health status (SRH) as perceived by older adult men and women with metabolic syndrome during the COVID-19 lockdown. Methods: We analyzed data from 4681 Spanish adults with metabolic syndrome. We carried out a telephone survey during May and June 2020 to collect information on demographics, dietary habits, PA, sleep, SRH and anthropometric data. Results: The mean age of participants was 64.9 years at recruitment, and 52% of participants were men. Most participants (64.1%) perceived a decrease in their PA during confinement. Regarding gender-specific differences, a higher proportion of women than men perceived a decrease in their PA (67.5% vs. 61.1%), Mediterranean diet adherence (20.9% vs. 16.8%), sleep hours (30.3% vs. 19.1%), sleep quality (31.6% vs. 18.2%) and SRH (25.9% vs. 11.9%) (all p < 0.001). Conclusions: The COVID-19 lockdown affected women more negatively, particularly their self-reported diet, PA, sleep and health status. [ABSTRACT FROM AUTHOR]
Published: 2024
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8. Dietary Iron, Anemia Markers, Cognition, and Quality of Life in Older Community-Dwelling Subjects at High Cardiovascular Risk

Author: Donat-Vargas, Carolina, primary, Mico, Víctor, additional, San-Cristobal, Rodrigo, additional, Martínez-González, Miguel Ángel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Fitó, Montserrat, additional, Alonso-Gómez, Ángel Maria, additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, López-Miranda, José, additional, Estruch, Ramon, additional, Damas-Fuentes, Miguel, additional, Lapetra, José, additional, Serra-Majem, Luís, additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep Antoni, additional, Cinza-Sanjurjo, Sergio, additional, Pintó, Xavier, additional, Delgado-Rodríguez, Miguel, additional, Matía-Martín, Pilar, additional, Vidal, Josep, additional, Causso, Claudia, additional, Ros, Emilio, additional, Toledo, Estefanía, additional, Manzanares, Josep Maria, additional, Ortega-Azorín, Carolina, additional, Castañer, Olga, additional, Peña-Orihuela, Patricia Judith, additional, Zazo, Juan Manuel, additional, Muñoz Bravo, Carlos, additional, Martinez-Urbistondo, Diego, additional, Chaplin, Alice, additional, Casas, Rosa, additional, Cano Ibáñez, Naomi, additional, Tojal-Sierra, Lucas, additional, Gómez-Perez, Ana María, additional, Pascual Roquet-Jalmar, Elena, additional, Mestre, Cristina, additional, Barragán, Rocío, additional, Schröder, Helmut, additional, Garcia-Rios, Antonio, additional, Candela García, Inmaculada, additional, Ruiz-Canela, Miguel, additional, Babio, Nancy, additional, Malcampo, Mireia, additional, Daimiel, Lidia, additional, and Martínez, Alfredo, additional
Published: 2023
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9. Folic Acid Supplementation during Pregnancy and Its Association with Telomere Length in Children at Four Years: Results from the INMA Birth Cohort Study

Author: Petermann-Rocha, Fanny, primary, Valera-Gran, Desirée, additional, Prieto-Botella, Daniel, additional, Martens, Dries S, additional, Gonzalez-Palacios, Sandra, additional, Riaño-Galán, Isolina, additional, Murcia, Mario, additional, Irizar, Amaia, additional, Julvez, Jordi, additional, Santa-Marina, Loreto, additional, Tardón, Adonina, additional, Sunyer, Jordi, additional, Vioque, Jesús, additional, Nawrot, Tim, additional, and Navarrete-Muñoz, Eva-María, additional
Published: 2023
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10. Prenatal Vitamin D Levels Influence Growth and Body Composition until 11 Years in Boys

Author: Sanguesa, Julia, primary, Marquez, Sandra, additional, Bustamante, Mariona, additional, Sunyer, Jordi, additional, Iniguez, Carmen, additional, Vioque, Jesus, additional, Rodriguez, Loreto Santa-Marina, additional, Jimeno-Romero, Alba, additional, Torrent, Matias, additional, Casas, Maribel, additional, and Vrijheid, Martine, additional
Published: 2023
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11. Caffeine and the Risk of Diabetic Retinopathy in Type 2 Diabetes Mellitus: Findings from Clinical and Experimental Studies

Author: Alcubierre, Nuria, primary, Granado-Casas, Minerva, additional, Bogdanov, Patricia, additional, Hernández, Cristina, additional, Ramos, Hugo, additional, Castelblanco, Esmeralda, additional, Real, Jordi, additional, Rubinat-Arnaldo, Esther, additional, Traveset, Alicia, additional, Hernández, Marta, additional, Jurjo, Carmen, additional, Vioque, Jesús, additional, Navarrete-Muñoz, Eva Maria, additional, Simó, Rafael, additional, and Mauricio, Didac, additional
Published: 2023
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12. Use of Different Food Classification Systems to Assess the Association between Ultra-Processed Food Consumption and Cardiometabolic Health in an Elderly Population with Metabolic Syndrome (PREDIMED-Plus Cohort)

Author: Josep Vidal, Jose M. Ordovas, José Alfredo Martínez, Ángel M. Alonso-Gómez, Estefanía Toledo, Nerea Becerra-Tomás, Dolores Corella, Aurora Bueno-Cavanillas, Jessica Vaquero-Luna, María Concepción Barceló-Iglesias, Beatriz Pérez-Sanz, Antonio García Ríos, María Julia Ajejas Bazán, Ramon Estruch, Vicente Martín Sánchez, Rodrigo San-Cristobal, Miguel Ángel Martínez-González, Xavier Pintó, Dora Romaguera, Jesús Vioque, José J. Gaforio, Pilar Matía-Martín, Lluis Serra-Majem, Itziar Abete, Camille Lassale, Júlia Muñoz-Martínez, Jose Lopez-Miranda, Stephanie K. Nishi, José Lapetra, Lidia Daimiel, Anai Moreno-Rodriguez, Clotilde Vázquez, José V. Sorlí, Celia Martinez-Perez, José Manuel Santos-Lozano, Maira Bes-Rastrollo, Julia Wärnberg, Emilio Ros, María Rosa Bernal-López, Pilar Guallar-Castillón, Nancy Babio, Oscar Lecea-Juarez, María Dolores Zomeño, Olga Castañer, Josep A. Tur, Jordi Salas-Salvadó, Francisco J. Tinahones, Olga Portolés, Jadwiga Konieczna, [Martinez-Perez,C, Ordovás,JM, Daimiel,L] Nutritional Genomics and Epigenomics Group, Precision Nutrition and Obesity Program, IMDEA Food, CEI UAM + CSIC, Madrid, Spain. [San-Cristobal,R, Martinez, JA] Cardiometabolic Nutrition Group, Precision Nutrition and Cardiometabolic Health Program, IMDEA Food, CEI UAM + CSIC, Madrid, Spain. [Guallar-Castillon,P] Cardiovascular and Nutritional Epidemiology Group, IMDEA Food, CEI UAM + CSIC, Madrid, Spain. [Guallar-Castillon,P] Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid—IdiPaz Hospital, Madrid, Spain. [Guallar-Castillon,P, Vioque,J, Bueno-Cavanillas,A, Martín Sánchez,V, Gaforio,JJ] Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain. [Guallar-Castillon,P] Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University, Baltimore, USA. [Martínez-González,MA, Salas-Salvadó,J, Corella,D, Castañer,O, Martinez,JA, Alonso-Gómez,AM, Wärnberg,J, Romaguera,D, López-Miranda,J, Estruch,R, Tinahones,FJ, Lapetra,J, Serra-Majem,L, Tur,JA, Pintó,X, Vázquez,C, Ros,E, Bes-Rastrollo,M, Babio,N, Sorlí,JV, Lassale,C, Vaquero-Luna,J, Konieczna,J, García Ríos,A, Santos-Lozano,JM, Toledo,E, Becerra-Tomás,N, Portoles,O, Abete,I, Moreno-Rodriguez,A] Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. [Martínez-González,MA, Toledo,E] Department of Preventive Medicine and Public Health, University of Navarra, IdiSNA, Pamplona, Spain. [Martínez-González,MA] Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA, USA. [Salas-Salvadó,J, Becerra-Tomás,T, Nishi,SK] Unitat de Nutrició Humana, Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili, Reus, Spain. [Salas-Salvadó,J, Becerra-Tomás,N] Human Nutrition Unit, Institut d’Investigació Sanitària Pere Virgili (IISPV), Reus, Spain. [Corella,D, Portoles,O] Department of Preventive Medicine, University of Valencia, Valencia, Spain. [Castañer,O, Zomeño,MD, Muñoz-Martínez,J] Cardiovascular Risk and Nutrition Research Group (CARIN), Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain. [Martinez,JA, Pérez-Sanz,B, Abete,I] Department of Nutrition, Food Sciences and Physiology, University of Navarra, Pamplona, Spain. [Alonso-Gómez,AM, Moreno-Rodriguez,A] Bioaraba Health Research Institute, Osakidetza Basque Health Service, Araba University Hospital, University of the Basque Country UPV/EHU, Vitoria-Gasteiz, Spain. [Wärnberg, Ajejas Bazán,MJ] Department of Nursing, School of Health Sciences, Instituto de Investigación Biomédica de Málaga (IBIMA), University of Málaga, Málaga. [Vioque,J] Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL-UMH), Alicante, Spain. [Romaguera,D, Konieczna,J] Research Group on Nutritional Epidemiology & Cardiovascular Physiopathology (NUTRECOR), Health Research Institute of the Balearic Islands (IdISBa), University Hospital Son Espases (HUSE), Palma de Mallorca, Spain. [López-Miranda,J, García Ríos,A] Lipids and Atherosclerosis Unit, Department of Internal Medicine, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Córdoba, Spain. [Estruch,R] Department of Internal Medicine, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain. [Tinahones,FJ] Department of Endocrinology, Instituto de Investigación Biomédica de Málaga (IBIMA), Virgen de la Victoria Hospital, University of Málaga, Málaga, Spain. [Lapetra,J, Santos-Lozano,JM] Department of Family Medicine, Research Unit, Distrito Sanitario Atención Primaria Sevilla, Sevilla, Spain. [Serra-Majem,L] Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria and Service of Preventive Medicine, Complejo Hospitalario Universitario Insular Materno Infantil (CHUIMI), Canary Health Service, Las Palmas de Gran Canaria, Spain. [Bueno-Cavanillas,A] Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain. [Tur,JA] Research Group on Community Nutrition & Oxidative Stress, University of Balearic Islands-IUNICS & IDISBA, Palma de Mallorca, Spain. [Martín Sánchez,V] Institute of Biomedicine (IBIOMED), University of León, León, Spain. [Pintó,X] Lipids and Vascular Risk Unit, Internal Medicine, Hospital Universitario de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain. [Gaforio,JJ] Departamento de Ciencias de la Salud, Centro de Estudios Avanzados en Olivar y Aceites de Oliva, Universidad de Jaén, Jaén, Spain. [Matía-Martín,P] Department of Endocrinology and Nutrition, Instituto de Investigación Sanitaria Hospital Clínico San Carlos (IdISSC), Madrid, Spain. [Vidal,J] Biomedical Research Centre for Diabetes and Metabolic Diseases Network (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. [Vidal,J, Ros,E] Endocrinology and Nutrition Service, IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain. [Vázquez,C] Department of Endocrinology and Nutrition, Hospital Fundación Jiménez Díaz, Instituto de Investigaciones Biomédicas IISFJD, University Autónoma, Madrid, Spain. [Ajejas Bazán,MJ] Department of Nursing, Faculty of Nursing, Physiotherapy and Podiatry, Universidad Complutense de Madrid, Madrid, Spain. [Barceló-Iglesias,MC] Centro Salud Cabo Huertas, Alicante, Spain. [Bernal-López,MR] Internal Medicine Department, Instituto de Investigación Biomédica de Málaga (IBIMA), Regional University Hospital of Malaga, Malaga, Spain. [Zomeño,MD] School of Health Sciences, Blanquerna-Ramon Llull University, Barcelona, Spain. [Lecea-Juarez,O] Atención Primaria, Osasunbidea, Servicio Navarro de Salud, Pamplona, Spain. [Ordovás,JM] Nutrition and Genomics Laboratory, JM_USDA Human Nutrition Research Center on Aging, Tufts University, Boston, USA., The PREDIMED-Plus trial was supported by the European Research Council (Advanced Research grant 2014–2019, agreement #340918, granted to M.Á.M.-G.), the official Spanish institutions for funding scientific biomedical research, CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN) and Instituto de Salud Carlos III (ISCIII) through the Fondo de Investigación para la Salud (FIS) which is co-funded by the European Regional Development Fund (coordinated FIS projects led by J.S-S. and J.V., including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332), and the Especial Action Project 'Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus' (J.S.-S.), the Recercaixa (grant number 2013ACUP00194) (J.S.-S.). Moreover, J.S-S. gratefully acknowledges the financial support by ICREA under the ICREA Academia program, the SEMERGEN grant, Department of Health of the Government of Navarra (61/2015), the Fundació La Marató de TV (Ref. 201630.10), the AstraZeneca Young Investigators Award in Category of Obesity and T2D 2017 (D.R.), grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013, PS0358/2016, PI0137/2018), the PROMETEO/2017/017 grant from the Generalitat Valenciana, the SEMERGEN grant, grant of support to research groups 35/2011 (Balearic Islands Government, and FEDER funds) (J.A.T.). R.S.-C. acknowledges financial support from the Juan de la Cierva Program Training Grants of the Spanish State Research Agency of the Spanish Ministerio de Ciencia e Innovación y Ministerio de Universidades (FJC2018-038168- I). N.B.-T. acknowledges financial support from the Juan de la Cierva Formación Program Training Grants of the Spanish State Research Agency of the Spanish Ministerio de Ciencia e Innovación y Ministerio de Universidades (FJC2018-036016-I). M.R.B.-L. was supported by 'Miguel Servet Type I' program (CP15/00028) from the ISCIII-Madrid (Spain), cofinanced by the Fondo Europeo de Desarrollo Regional-FEDER. S.K.N. acknowledges financial support from the Canadian Institute for Health Research, CIHR Fellowship. J.K. was supported by the ‘FOLIUM’ programme within the FUTURMed project from the Fundación Instituto de Investigación Sanitaria Illes Balears (financed by 2017 annual plan of the sustainable tourism tax and at 50% with charge to the ESF Operational Program 2014–2020 of the Balearic Islands. C.M.-P. was financially supported by a joint grant from the Community of Madrid and the European Social Fund (grant PEJD-2019-POST/SAL-15892). The METHYL-UP project was supported by the Spanish Ministry of Science and Innovation (RTI2018-095569-B-I00, Programa de Proyectos Orientados a los Retos de la Sociedad 'Projects Toward Society Challenges Program').
Subjects: Síndrome metabólico, Male, Food processing, Mediterranean diet, NOVA, Obesidad, Índice de masa corporal, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], 0302 clinical medicine, ultra-processed food, Medicine, TX341-641, Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Body Weight::Overweight [Medical Subject Headings], Body mass index, classification systems, Incidence, IARC, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Questionnaires [Medical Subject Headings], Metabolic syndrome, 3. Good health, Nutrición, Cohort, Manipulación de alimentos, Dieta, Factores de riesgo cardiometabólico, Concordance, UNC, Check Tags::Male [Medical Subject Headings], Clasificación, Classification systems, Diet Surveys, Article, 03 medical and health sciences, food processing, Humans, Diseases::Cardiovascular Diseases [Medical Subject Headings], Aged, 030109 nutrition & dietetics, Health Care::Health Care Economics and Organizations::Organizations::International Agencies [Medical Subject Headings], Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], PREDIMED-Plus, medicine.disease, Obesity, Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity [Medical Subject Headings], Blood pressure, Check Tags::Female [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies [Medical Subject Headings], Linear Models, Fast Foods, Older people, 0301 basic medicine, Síndrome metabòlica, Food Handling, Overweight, Diet, Mediterranean, Persones grans, Cohort Studies, cardiometabolic risk, Endocrinología, 030212 general & internal medicine, Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings], 2. Zero hunger, Metabolic Syndrome, Nutrition and Dietetics, Technology and Food and Beverages::Technology, Industry, and Agriculture::Industry::Food Industry::Food Handling [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Nutrition Therapy::Diet Therapy::Diet, Mediterranean [Medical Subject Headings], Middle Aged, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Health Surveys::Nutrition Surveys::Diet Surveys [Medical Subject Headings], Female, Technology and Food and Beverages::Food and Beverages::Food::Fast Foods [Medical Subject Headings], medicine.symptom, Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Hyperinsulinism::Insulin Resistance::Metabolic Syndrome X [Medical Subject Headings], Dietética y nutrición, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Body Constitution::Body Weights and Measures::Body Mass Index [Medical Subject Headings], Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Incidence [Medical Subject Headings], Environmental health, Alimentos ultraprocesados, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models, Statistical::Linear Models [Medical Subject Headings], Nutrició, Nutrition, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], business.industry, Nutrition. Foods and food supply, Cardiometabolic Risk Factors, Dieta mediterránea, Cardiometabolic risk, Ultra-processed food, Diet, Spain, IFIC, Sobrepeso, business, diet, Food Science
Abstract: The PREDIMED-Plus trial was supported by the European Research Council (Advanced Research grant 2014–2019; agreement #340918; granted to M.Á.M.-G.); the official Spanish institutions for funding scientific biomedical research, CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN) and Instituto de Salud Carlos III (ISCIII) through the Fondo de Investigación para la Salud (FIS) which is co-funded by the European Regional Development Fund (coordinated FIS projects led by J.S-S. and J.V., including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332), and the Especial Action Project “Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-Plus” (J.S.-S.); the Recercaixa (grant number 2013ACUP00194) (J.S.-S.). Moreover, J.S-S. gratefully acknowledges the financial support by ICREA under the ICREA Academia program; the SEMERGEN grant; Department of Health of the Government of Navarra (61/2015), the Fundació La Marató de TV (Ref. 201630.10); the AstraZeneca Young Investigators Award in Category of Obesity and T2D 2017 (D.R.); grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013; PS0358/2016; PI0137/2018), the PROMETEO/2017/017 grant from the Generalitat Valenciana, the SEMERGEN grant; grant of support to research groups 35/2011 (Balearic Islands Government; FEDER funds) (J.A.T.). R.S.-C. acknowledges financial support from the Juan de la Cierva Program Training Grants of the Spanish State Research Agency of the Spanish Ministerio de Ciencia e Innovación y Ministerio de Universidades (FJC2018-038168- I). N.B.-T. acknowledges financial support from the Juan de la Cierva Formación Program Training Grants of the Spanish State Research Agency of the Spanish Ministerio de Ciencia e Innovación y Ministerio de Universidades (FJC2018-036016-I). M.R.B.-L. was supported by “Miguel Servet Type I” program (CP15/00028) from the ISCIII-Madrid (Spain), cofinanced by the Fondo Europeo de Desarrollo Regional-FEDER. S.K.N. acknowledges financial support from the Canadian Institute for Health Research, CIHR Fellowship. J.K. was supported by the ‘FOLIUM’ programme within the FUTURMed project from the Fundación Instituto de Investigación Sanitaria Illes Balears (financed by 2017 annual plan of the sustainable tourism tax and at 50% with charge to the ESF Operational Program 2014–2020 of the Balearic Islands. C.M.-P. was financially supported by a joint grant from the Community of Madrid and the European Social Fund (grant PEJD-2019- POST/SAL-15892). The METHYL-UP project was supported by the Spanish Ministry of Science and Innovation (RTI2018-095569-B-I00, Programa de Proyectos Orientados a los Retos de la Sociedad “Projects Toward Society Challenges Program”)., The association between ultra-processed food (UPF) and risk of cardiometabolic disorders is an ongoing concern. Different food processing-based classification systems have originated discrepancies in the conclusions among studies. To test whether the association between UPF consumption and cardiometabolic markers changes with the classification system, we used baseline data from 5636 participants (48.5% female and 51.5% male, mean age 65.1 4.9) of the PREDIMEDPlus (“PREvention with MEDiterranean DIet”) trial. Subjects presented with overweight or obesity and met at least three metabolic syndrome (MetS) criteria. Food consumption was classified using a 143-item food frequency questionnaire according to four food processing-based classifications: NOVA, International Agency for Research on Cancer (IARC), International Food Information Council (IFIC) and University of North Carolina (UNC). Mean changes in nutritional and cardiometabolic markers were assessed according to quintiles of UPF consumption for each system. The association between UPF consumption and cardiometabolic markers was assessed using linear regression analysis. The concordance of the different classifications was assessed with intra-class correlation coefficients (ICC3, overall = 0.51). The highest UPF consumption was obtained with the IARC classification (45.9%) and the lowest with NOVA (7.9%). Subjects with high UPF consumption showed a poor dietary profile. We detected a direct association between UPF consumption and BMI (p = 0.001) when using the NOVA system, and with systolic (p = 0.018) and diastolic (p = 0.042) blood pressure when using the UNC system. Food classification methodologies markedly influenced the association between UPF consumption and cardiometabolic risk markers., European Research Council (ERC) European Commission #340918, Centro de Investigacion Biomedica en Red-Fisiopatologia de la Obesidad y Nutricion PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441 PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/00636, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI14/00972, PI14/00728, PI14/01471 PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01332
Published: 2021
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13. Adherence to Pro-Vegetarian Food Patterns and Risk of Oesophagus, Stomach, and Pancreas Cancers: A Multi Case-Control Study (The PANESOES Study)

Author: Alejandro Oncina-Cánovas, Sandra González-Palacios, Leyre Notario-Barandiaran, Laura Torres-Collado, Antonio Signes-Pastor, Enrique de-Madaria, Miguel Santibañez, Manuela García-de la Hera, Jesús Vioque, and Universidad de Cantabria
Subjects: Nutrition and Dietetics, Stomach, Pancreatic Neoplasms, Oesophagus, Logistic Models, Esophagus, Stomach Neoplasms, pro-vegetarian food patterns, oesophagus, stomach, pancreas, cancer, food quality, Case-Control Studies, Humans, Pro-vegetarian food patterns, Pancreas, Cancer, Food quality, Food Science, Vegetarians
Abstract: We aimed to evaluate the association between three previously defined pro-vegetarian (PVG) food patterns and the cancers of the oesophagus, stomach, and pancreas in a multi case-control study. We analyzed data from a multi-case hospital-based study carried out in two Mediterranean provinces in Spain. A total of 1233 participants were included in the analyses: 778 incident cancer cases, histologically confirmed (199 oesophagus, 414 stomach, and 165 pancreas) and 455 controls. A dietary assessment was performed using a validated food frequency questionnaire (FFQ). Three PVG food patterns (general, healthful, and unhealthful) were estimated using 12 food groups for the general PVG (gPVG), scoring positive plant-based foods and negative animal-based foods, and 18 food groups, for the healthful (hPVG) and unhealthful (uPVG) food patterns. Multinomial logistic regression was used to estimate relative risk ratios (RRR) and confidence intervals (95% CI) for quintiles of adherence to PVG patterns and as a continuous variable. The RRR (95% CI) for the highest vs. the lowest quintile of gPVG were, RRR = 0.37 (0.32, 0.42) for the oesophagus, RRR = 0.34 (0.27, 0.43) for the stomach, and RRR = 0.43 (0.35, 0.52) for pancreas cancer. For the hPVG, the RRR were RRR = 0.72 (0.58, 0.90) for the oesophagus, RRR = 0.42 (0.34, 0.52) for the stomach, and RRR = 0.74 (0.59, 0.92) for pancreas cancer. The uPVG was associated with a higher risk of stomach cancer RRR = 1.76 (1.42, 2.18). Higher adherence to gPVG and hPVG food patterns is associated with a lower risk of oesophageal, stomach, and pancreas cancers, while a higher adherence to a uPVG food pattern is associated with a higher risk of stomach cancer. Funding: This work was supported by the Spanish Ministry of Health (FIS 91/0435, RCESP C03/09), the Generalitat Valenciana (EVES 030/2005, CTGCA/2002/06, G03/136), CIBERESP.
Published: 2022

14. Adherence to Pro-Vegetarian Food Patterns and Risk of Oesophagus, Stomach, and Pancreas Cancers: A Multi Case–Control Study (The PANESOES Study)

Author: Oncina-Cánovas, Alejandro, primary, González-Palacios, Sandra, additional, Notario-Barandiaran, Leyre, additional, Torres-Collado, Laura, additional, Signes-Pastor, Antonio, additional, de-Madaria, Enrique, additional, Santibañez, Miguel, additional, García-de la Hera, Manuela, additional, and Vioque, Jesús, additional
Published: 2022
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15. Does Consumption of Ultra-Processed Foods Matter for Liver Health? Prospective Analysis among Older Adults with Metabolic Syndrome

Author: Konieczna, Jadwiga, primary, Fiol, Miguel, additional, Colom, Antoni, additional, Martínez-González, Miguel Ángel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Soria-Florido, María Trinidad, additional, Martínez, J. Alfredo, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, López-Miranda, José, additional, Estruch, Ramon, additional, Bernal-López, M. Rosa, additional, Lapetra, José, additional, Serra-Majem, Lluís, additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep A., additional, Martín Sánchez, Vicente, additional, Pintó, Xavier, additional, Gaforio, José J., additional, Matía-Martín, Pilar, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Daimiel, Lidia, additional, Ros, Emilio, additional, Bes-Rastrollo, Maira, additional, Pascual, María, additional, Sorlí, Jose V., additional, Goday, Albert, additional, Zulet, María Ángeles, additional, Moreno-Rodriguez, Anai, additional, Carmona González, Francisco Jesús, additional, Valls-Enguix, Rafael, additional, Janer, Juana M., additional, Garcia-Rios, Antonio, additional, Casas, Rosa, additional, Gomez-Perez, Ana M., additional, Santos-Lozano, José Manuel, additional, Basterra-Gortari, F. Javier, additional, Martínez, María Ángeles, additional, Ortega-Azorin, Carolina, additional, Bayó, Joan, additional, Abete, Itziar, additional, Salaverria-Lete, Itziar, additional, Ruiz-Canela, Miguel, additional, Babio, Nancy, additional, Carres, Lourdes, additional, and Romaguera, Dora, additional
Published: 2022
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16. Prenatal Vitamin D Levels Influence Growth and Body Composition until 11 Years in Boys

Author: Julia Sanguesa, Sandra Marquez, Mariona Bustamante, Jordi Sunyer, Carmen Iniguez, Jesus Vioque, Loreto Santa-Marina Rodriguez, Alba Jimeno-Romero, Matias Torrent, Maribel Casas, Martine Vrijheid, and European Commission
Subjects: epidemiology, pregnancy, paediatrics, vitamin D, growth, body mass index, fat mass, overweight, Nutrition and Dietetics, Fat mass, Epidemiology, Pregnancy, Paediatrics, Growth, Overweight, Vitamin D, Body mass index, Food Science
Abstract: Background: Gestational vitamin D levels may influence offspring growth and modulate adipogenesis. Findings from prospective studies are inconsistent, and few have evaluated the persistence of these associations into late childhood. Objective: To examine the association between prenatal vitamin D levels and growth and adiposity in late childhood. Methods: We included 2027 mother–child pairs from the INMA birth cohort. 25-hydroxyvitamin D3 (vitamin D3) levels were measured in serum at 13 weeks of pregnancy. Sex- and age-specific body mass index z-scores were calculated at 7 and 11 years, overweight was defined as z-score ≥ 85th percentile, and body fat mass was measured at 11 years. Z-score body mass index (zBMI) trajectories from birth to 11 years were identified using latent class growth analysis. Results: The prevalence of vitamin D3 deficiency (
Published: 2023
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17. Association between Dietary Diversity and All-Cause Mortality: A Multivariable Model in a Mediterranean Population with 18 Years of Follow-Up

Author: Torres-Collado, Laura, primary, García-de la Hera, Manuela, additional, Cano-Ibañez, Naomi, additional, Bueno-Cavanillas, Aurora, additional, and Vioque, Jesús, additional
Published: 2022
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18. Omega-3 Fatty Acid Intake during Pregnancy and Child Neuropsychological Development: A Multi-Centre Population-Based Birth Cohort Study in Spain

Author: Tahaei, Hana, primary, Gignac, Florence, additional, Pinar, Ariadna, additional, Fernandez-Barrés, Silvia, additional, Romaguera, Dora, additional, Vioque, Jesus, additional, Santa-Marina, Loreto, additional, Subiza-Pérez, Mikel, additional, Llop, Sabrina, additional, Soler-Blasco, Raquel, additional, Arija, Victoria, additional, Salas-Salvadó, Jordi, additional, Tardón, Adonina, additional, Riaño-Galán, Isolina, additional, Sunyer, Jordi, additional, Guxens, Monica, additional, and Julvez, Jordi, additional
Published: 2022
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19. Coffee Consumption and All-Cause, Cardiovascular, and Cancer Mortality in an Adult Mediterranean Population

Author: Alejandro Oncina-Canovas, Jesús Vioque, Manuela García de la Hera, Leyre Notario-Barandiaran, Sandra Gonzalez-Palacios, Laura Torres-Collado, and Laura Compañ-Gabucio
Subjects: Adult, Male, Population, 030209 endocrinology & metabolism, Coffee consumption, lcsh:TX341-641, Lower risk, Coffee, Article, Beverages, 03 medical and health sciences, 0302 clinical medicine, cardiovascular disease, Neoplasms, Surveys and Questionnaires, Medicine, cancer, Humans, 030212 general & internal medicine, education, Cancer mortality, caffeinated, education.field_of_study, Nutrition and Dietetics, business.industry, Proportional hazards model, Mediterranean Region, Incidence, Hazard ratio, Cancer, Middle Aged, medicine.disease, mortality, Confidence interval, Cardiovascular Diseases, Spain, decaffeinated, Female, business, lcsh:Nutrition. Foods and food supply, Food Science, Demography, Follow-Up Studies
Abstract: We assessed the association between usual coffee consumption and all-cause, cardiovascular (CV), and cancer mortality in an adult population in Spain, taking into account both the amount and type of coffee consumed. We used baseline data on coffee consumption and other personal variables, and the number of deaths during an 18-year follow-up period, for 1567 participants aged 20 years and older from the Valencia Nutrition Study in Spain. Total, caffeinated, and decaffeinated coffee consumption was assessed using a validated food frequency questionnaire. Cox regression models were used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). During the 18-year follow-up period, 317 died, 115 due to CV disease and 82 due to cancer. Compared with no-consumption, the consumption of ≤1 cup per day and &gt, 1 cup per day of coffee was associated with a lower risk of all-cause mortality, HR = 0.73 (95% CI: 0.56–0.97) and HR 0.56 (95% CI: 0.41–0.77), respectively. A lower cancer mortality was observed among drinkers of more than 1 cup per day compared with nondrinkers, HR 0.41 (95% CI 0.20–0.86). Regarding the type of coffee, only the overall consumption of caffeinated coffee was associated with lower all-cause mortality at 12 and 18 years of follow-up, HR = 0.66 (95% CI:0.46–0.94) and HR = 0.59 (95CI: 0.44–0.79), respectively. In conclusion, this study suggests that the moderate consumption of coffee, particularly caffeinated coffee (range 1–6.5 cups per day), is associated with a lower all-cause and cancer mortality after a long follow-up period. No significant association was found between coffee consumption and CVD mortality.
Published: 2021

20. Self-Reported DHA Supplementation during Pregnancy and Its Association with Obesity or Gestational Diabetes in Relation to DHA Concentration in Cord and Maternal Plasma: Results from NELA, a Prospective Mother-Offspring Cohort

Author: Antonio Gázquez, María J. Giménez-Bañón, María T. Prieto-Sánchez, Carmen Martínez-Graciá, Clara Suárez, Marina Santaella-Pascual, Lina Galdo-Castiñeira, Carmen Ballesteros-Meseguer, Jesús Vioque, Miriam Martínez-Villanueva, Francisco Avilés-Plaza, José A. Noguera-Velasco, Eva Morales, Luís García-Marcos, Elvira Larqué, and the Nela Study Group
Subjects: 0301 basic medicine, Adult, Male, obesity, genetic structures, Docosahexaenoic Acids, Physiology, lcsh:TX341-641, 030209 endocrinology & metabolism, Overweight, Article, Body Mass Index, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Diabetes mellitus, Medicine, Humans, Prospective Studies, Fetus, 030109 nutrition & dietetics, Nutrition and Dietetics, diabetes, business.industry, Fatty Acids, Infant, Newborn, nutritional and metabolic diseases, food and beverages, Maternal Nutritional Physiological Phenomena, docosahexaenoic acid, medicine.disease, Fetal Blood, Gestational diabetes, Pregnancy Complications, Diabetes, Gestational, Docosahexaenoic acid, supplementation, Dietary Supplements, Gestation, lipids (amino acids, peptides, and proteins), Female, medicine.symptom, business, lcsh:Nutrition. Foods and food supply, Body mass index, Food Science
Abstract: Maternal supplementation of docosahexaenoic acid (DHA) during pregnancy has been recommended due to its role in infant development, but its effect on materno-fetal DHA status is not well established. We evaluated the associations between DHA supplementation in pregnant women with obesity or gestational diabetes mellitus (GDM) and maternal and neonatal DHA status. Serum fatty acids (FA) were analyzed in 641 pregnant women (24 weeks of gestation) and in 345 venous and 166 arterial cord blood samples of participants of the NELA cohort. Obese women (n = 47) presented lower DHA in serum than those lean (n = 397) or overweight (n = 116) before pregnancy. Linoleic acid in arterial cord was elevated in obese women, which indicates lower fetal retention. Maternal DHA supplementation (200 mg/d) during pregnancy was associated with enhanced maternal and fetal DHA levels regardless of pre-pregnancy body mass index (BMI), although higher arterial DHA in overweight women indicated an attenuated response. Maternal DHA supplementation was not associated with cord venous DHA in neonates of mothers with GDM. The cord arteriovenous difference was similar for DHA between GDM and controls. In conclusion, maternal DHA supplementation during pregnancy enhanced fetal DHA status regardless of the pre-pregnancy BMI while GDM may reduce the effect of DHA supplementation in newborns.
Published: 2021

21. The Use of Lower or Higher Than Recommended Doses of Folic Acid Supplements during Pregnancy Is Associated with Child Attentional Dysfunction at 4–5 Years of Age in the INMA Project

Author: Ana Fernández-Somoano, Martine Vrijheid, Mario Murcia, Manuela García de la Hera, Laura Torres Collado, Marisa Rebagliato, Jesús Ibarluzea, Mònica Guxens, Laura María Compañ Gabucio, Adonina Tardón, Jesús Vioque, Itxaso Martí, Child and Adolescent Psychiatry / Psychology, and Erasmus MC other
Subjects: Adult, Male, medicine.medical_specialty, lcsh:TX341-641, 030209 endocrinology & metabolism, Neuropsychological Tests, Article, 03 medical and health sciences, folic acid, Child Development, 0302 clinical medicine, children, Supplement use, Humans, Medicine, Attention, Prospective Studies, supplement use, attentional function, Pregnancy, Nutrition and Dietetics, neurodevelopment, business.industry, Obstetrics, medicine.disease, Confidence interval, 3. Good health, Standard error, Folic acid, Spain, Child, Preschool, Prenatal Exposure Delayed Effects, Dietary Supplements, Cohort, Linear Models, Female, pregnancy, business, lcsh:Nutrition. Foods and food supply, 030217 neurology & neurosurgery, Food Science
Abstract: We assessed the association between the use of lower- and higher-than-recommended doses of folic acid supplements (FAs) during pregnancy and attentional function in boys and girls at age of 4–5. We analyzed data from 1329 mother-child pairs from the mother-child cohort INfancia y Medio Ambiente Project (INMA) study. Information on FAs use during pregnancy was collected in personal interviews at weeks 12 and 30, and categorized in &lt, 400, 400–999 (recommended dose), and ≥1000 μg/day. Child attentional function was assessed by Conners’ Kiddie Continuous Performance Test. Multivariable regression analyses were used to estimate incidence rate ratios (IRR) and beta coefficients with 95% confidence intervals (CI). Compared to recommended FAs doses, the periconceptional use of &lt, 400 and ≥1000 μg/day was associated with higher risk of omission errors—IRR = 1.14 (95% CI: 1.01, 1.29) and IRR = 1.16 (95% CI: 1.02, 1.33), respectively. The use of FAs &lt, 400 μg/day and ≥1000 μg/day was significantly associated with deficits of attentional function only in boys. FAs use &lt, 400 μg/day was associated with higher omission errors with IRR = 1.22 and increased hit reaction time (HRT) β = 34.36, and FAs use ≥ 1000 μg/day was associated with increased HRT β = 33.18 and HRT standard error β = 3.31. The periconceptional use of FAs below or above the recommended doses is associated with deficits of attentional function in children at age of 4–5, particularly in boys.
Published: 2021
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22. Use of Different Food Classification Systems to Assess the Association between Ultra-Processed Food Consumption and Cardiometabolic Health in an Elderly Population with Metabolic Syndrome (PREDIMED-Plus Cohort)

Author: Martinez-Perez, Celia, primary, San-Cristobal, Rodrigo, additional, Guallar-Castillon, Pilar, additional, Martínez-González, Miguel Ángel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Castañer, Olga, additional, Martinez, Jose Alfredo, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, López-Miranda, José, additional, Estruch, Ramon, additional, Tinahones, Francisco J., additional, Lapetra, José, additional, Serra-Majem, Lluis, additional, Bueno-Cavanillas, Aurora, additional, Tur, Josep A., additional, Sánchez, Vicente Martín, additional, Pintó, Xavier, additional, Gaforio, José J., additional, Matía-Martín, Pilar, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Ros, Emilio, additional, Bes-Rastrollo, Maira, additional, Babio, Nancy, additional, Sorlí, Jose V., additional, Lassale, Camille, additional, Pérez-Sanz, Beatriz, additional, Vaquero-Luna, Jessica, additional, Bazán, María Julia Ajejas, additional, Barceló-Iglesias, María Concepción, additional, Konieczna, Jadwiga, additional, Ríos, Antonio García, additional, Bernal-López, María Rosa, additional, Santos-Lozano, José Manuel, additional, Toledo, Estefanía, additional, Becerra-Tomás, Nerea, additional, Portoles, Olga, additional, Zomeño, María Dolores, additional, Abete, Itziar, additional, Moreno-Rodriguez, Anai, additional, Lecea-Juarez, Oscar, additional, Nishi, Stephanie K., additional, Muñoz-Martínez, Júlia, additional, Ordovás, José M., additional, and Daimiel, Lidia, additional
Published: 2021
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23. Clinical Utility of

Author: María L, Couce, Paula, Sánchez-Pintos, Emiliano, González-Vioque, and Rosaura, Leis
Subjects: Male, Polymorphism, Genetic, Adolescent, Genotype, Gastrointestinal Diseases, C/T-13910 polymorphism, lactose malabsorption, Article, Diet, lactose intolerance, Cross-Sectional Studies, Phenotype, Breath Tests, Gene Frequency, Child, Preschool, Humans, Female, Dairy Products, functional gastrointestinal disorders, Child, Hydrogen, Lactase
Abstract: Genetic testing is a good predictor of lactase persistence (LP) in specific populations but its clinical utility in children is less clear. We assessed the role of lactose malabsorption in functional gastrointestinal disorders (FGID) in children and the correlation between the lactase non-persistence (LNP) genotype and phenotype, based on exhaled hydrogen and gastrointestinal symptoms, during a hydrogen breath test (HBT). We also evaluate dairy consumption in this sample. We conducted a 10-year cross-sectional study in a cohort of 493 children with suspected FGID defined by Roma IV criteria. Distribution of the C/T-13910 genotype was as follows: CC, 46.0%; TT, 14.4% (LP allele frequency, 34.1%). The phenotype frequencies of lactose malabsorption and intolerance were 36.3% and 41.5%, respectively. We observed a strong correlation between genotype and both lactose malabsorption (Cramér’s V, 0.28) and intolerance (Cramér’s V, 0.54). The frequency of the LNP genotype (p = 0.002) and of malabsorption and intolerance increased with age (p = 0.001 and 0.002, respectively). In 61% of children, evaluated dairy consumption was less than recommended. No association was observed between dairy intake and diagnosis. In conclusion, we found a significant correlation between genotype and phenotype, greater in older children, suggesting that the clinical value of genetic testing increases with age.
Published: 2020

24. Coffee Consumption and All-Cause, Cardiovascular, and Cancer Mortality in an Adult Mediterranean Population

Author: Torres-Collado, Laura, primary, Compañ-Gabucio, Laura María, additional, González-Palacios, Sandra, additional, Notario-Barandiaran, Leyre, additional, Oncina-Cánovas, Alejandro, additional, Vioque, Jesús, additional, and García-de la Hera, Manuela, additional
Published: 2021
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25. The Use of Lower or Higher Than Recommended Doses of Folic Acid Supplements during Pregnancy Is Associated with Child Attentional Dysfunction at 4–5 Years of Age in the INMA Project

Author: Compañ Gabucio, Laura María, primary, García de la Hera, Manuela, additional, Torres Collado, Laura, additional, Fernández-Somoano, Ana, additional, Tardón, Adonina, additional, Guxens, Mònica, additional, Vrijheid, Martine, additional, Rebagliato, Marisa, additional, Murcia, Mario, additional, Ibarluzea, Jesús, additional, Martí, Itxaso, additional, and Vioque, Jesús, additional
Published: 2021
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26. Are Dietary Indices Associated with Polycystic Ovary Syndrome and Its Phenotypes? A Preliminary Study

Author: Cutillas-Tolín, Ana, primary, Arense-Gonzalo, Julián Jesús, additional, Mendiola, Jaime, additional, Adoamnei, Evdochia, additional, Navarro-Lafuente, Fuensanta, additional, Sánchez-Ferrer, María Luisa, additional, Prieto-Sánchez, María Teresa, additional, Carmona-Barnosi, Ana, additional, Vioque, Jesús, additional, and Torres-Cantero, Alberto M., additional
Published: 2021
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27. Dietary Quality Changes According to the Preceding Maximum Weight: A Longitudinal Analysis in the PREDIMED-Plus Randomized Trial

Author: Bouzas, Cristina, primary, Bibiloni, Maria del Mar, additional, Garcia, Silvia, additional, Mateos, David, additional, Martínez-González, Miguel Ángel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Schröder, Helmut, additional, Martínez, J. Alfredo, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Vioque, Jesús, additional, Romaguera, Dora, additional, Lopez-Miranda, José, additional, Estruch, Ramon, additional, Tinahones, Francisco J., additional, Lapetra, José, additional, Serra-Majem, Luís, additional, Bueno-Cavanillas, Aurora, additional, Micó-Pérez, Rafael M., additional, Pintó, Xavier, additional, Delgado-Rodríguez, Miguel, additional, Ortíz-Ramos, María, additional, Altés-Boronat, Andreu, additional, Luca, Bogdana L., additional, Daimiel, Lidia, additional, Ros, Emilio, additional, Sayon-Orea, Carmen, additional, Becerra-Tomás, Nerea, additional, Gimenez-Alba, Ignacio Manuel, additional, Castañer, Olga, additional, Abete, Itziar, additional, Tojal-Sierra, Lucas, additional, Pérez-López, Jéssica, additional, Bernabé-Casanova, Andrea, additional, Martin-Padillo, Marian, additional, Garcia-Rios, Antonio, additional, Castro-Barquero, Sara, additional, Fernández-García, José Carlos, additional, Santos-Lozano, José Manuel, additional, Fernandez-Lazaro, Cesar I., additional, Hernández-Alonso, Pablo, additional, Saiz, Carmen, additional, Zomeño, Maria Dolors, additional, Zulet, Maria Angeles, additional, Belló-Mora, Maria C., additional, Basterra-Gortari, F. Javier, additional, Canudas, Silvia, additional, Goday, Albert, additional, and Tur, Josep A., additional
Published: 2020
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28. Clinical Utility of LCT Genotyping in Children with Suspected Functional Gastrointestinal Disorder

Author: Couce, María L., primary, Sánchez-Pintos, Paula, additional, González-Vioque, Emiliano, additional, and Leis, Rosaura, additional
Published: 2020
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29. Adherence to the Mediterranean Lifestyle and Desired Body Weight Loss in a Mediterranean Adult Population with Overweight: A PREDIMED-Plus Study

Author: Bouzas, Cristina, primary, Bibiloni, Maria del Mar, additional, Julibert, Alicia, additional, Ruiz-Canela, Miguel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Zomeño, Maria Dolors, additional, Romaguera, Dora, additional, Vioque, Jesús, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Martínez, J. Alfredo, additional, Serra-Majem, Luís, additional, Estruch, Ramon, additional, Tinahones, Francisco J., additional, Lapetra, José, additional, Pintó, Xavier, additional, García Ríos, Antonio, additional, Bueno-Cavanillas, Aurora, additional, Gaforio, José J., additional, Matía-Martín, Pilar, additional, Daimiel, Lidia, additional, Martín-Sánchez, Vicente, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Ros, Emilio, additional, Fernandez-Lázaro, Cesar Ignacio, additional, Becerra-Tomás, Nerea, additional, Gimenez-Alba, Ignacio Manuel, additional, Muñoz, Julia, additional, Morey, Marga, additional, Oncina-Canovas, Alejandro, additional, Tojal-Sierra, Lucas, additional, Pérez-López, Jéssica, additional, Abete, Itziar, additional, Casañas-Quintana, Tamara, additional, Castro-Barquero, Sara, additional, Bernal-López, M. Rosa, additional, Santos-Lozano, José Manuel, additional, Galera, Ana, additional, Angullo-Martinez, Escarlata, additional, Basterra-Gortari, F. Javier, additional, Basora, Josep, additional, Saiz, Carmen, additional, Castañer, Olga, additional, Martín, Marian, additional, Notario-Barandiarán, Leyre, additional, Belló-Mora, María C., additional, Sayón-Orea, Carmen, additional, García-Gavilán, Jesús, additional, Goday, Albert, additional, and Tur, Josep A., additional
Published: 2020
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30. Reproducibility and Validity of a Food Frequency Questionnaire for Dietary Assessment in Adolescents in a Self-Reported Way

Author: Notario-Barandiaran, Leyre, primary, Freire, Carmen, additional, García-de-la-Hera, Manuela, additional, Compañ-Gabucio, Laura Mª, additional, Torres-Collado, Laura, additional, González-Palacios, Sandra, additional, Mundo, Antonio, additional, Molina, Marina, additional, Fernández, Mariana F., additional, and Vioque, Jesús, additional
Published: 2020
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31. Leisure-Time Physical Activity, Sedentary Behaviour and Diet Quality are Associated with Metabolic Syndrome Severity: The PREDIMED-Plus Study

Author: Gallardo-Alfaro, Laura, primary, Bibiloni, Maria del Mar, additional, Mascaró, Catalina M., additional, Montemayor, Sofía, additional, Ruiz-Canela, Miguel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Fitó, Montserrat, additional, Romaguera, Dora, additional, Vioque, Jesús, additional, Alonso-Gómez, Ángel M., additional, Wärnberg, Julia, additional, Martínez, J. Alfredo, additional, Serra-Majem, Lluís, additional, Estruch, Ramon, additional, Fernández-García, José Carlos, additional, Lapetra, José, additional, Pintó, Xavier, additional, García Ríos, Antonio, additional, Bueno-Cavanillas, Aurora, additional, Gaforio, José J., additional, Matía-Martín, Pilar, additional, Daimiel, Lidia, additional, Micó-Pérez, Rafael M., additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Ros, Emilio, additional, Fernandez-Lázaro, Cesar Ignacio, additional, Becerra-Tomás, Nerea, additional, Gimenez-Alba, Ignacio Manuel, additional, Zomeño, María Dolors, additional, Konieczna, Jadwiga, additional, Compañ-Gabucio, Laura, additional, Tojal-Sierra, Lucas, additional, Pérez-López, Jéssica, additional, Zulet, M. Ángeles, additional, Casañas-Quintana, Tamara, additional, Castro-Barquero, Sara, additional, Gómez-Pérez, Ana María, additional, Santos-Lozano, José Manuel, additional, Galera, Ana, additional, Basterra-Gortari, F. Javier, additional, Basora, Josep, additional, Saiz, Carmen, additional, Pérez-Vega, Karla Alejandra, additional, Galmés-Panadés, Aina M., additional, Tercero-Maciá, Cristina, additional, Sorto-Sánchez, Carolina, additional, Sayón-Orea, Carmen, additional, García-Gavilán, Jesús, additional, Muñoz-Martínez, Júlia, additional, and Tur, Josep A., additional
Published: 2020
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32. Dietary Polyphenol Intake is Associated with HDL-Cholesterol and A Better Profile of other Components of the Metabolic Syndrome: A PREDIMED-Plus Sub-Study

Author: Nerea Becerra-Tomás, Lidia Daimiel, Facundo Vitelli-Storelli, Rosa Casas, Anna Tresserra-Rimbau, José Lapetra, Pilar Matía-Martín, Luis Serra-Majem, Clotilde Vázquez, Mónica Doménech, Julia Wärnberg, María Rubín-García, Sandra González-Palacios, Pilar Buil-Cosiales, Leire Goicolea-Güemez, Maria Angeles Zulet, Jesús Vioque, José V. Sorlí, Inmaculada Bautista-Castaño, Jessica Pérez-López, Dora Romaguera, Jadwiga Konieczna, Montserrat Cofán, Nerea Martín-Calvo, Miguel Ruiz-Canela, Josep Vidal, Laura García-Molina, Ana María Gómez-Pérez, Dolores Corella, Ángel M. Alonso-Gómez, Montserrat Fitó, Vicente Martín-Sánchez, José Manuel Santos-Lozano, José Alfredo Martínez, Alicia Julibert, Aina M. Galmes-Panades, María Ángeles Rodríguez-Sanchez, Nancy Babio, Ramon Estruch, Álvaro Hernáez, Josep A. Tur, Xavier Pintó, Pablo Hernández-Alonso, Jordi Salas-Salvadó, Francisco J. Tinahones, Carolina Sorto-Sánchez, Rosa M. Lamuela-Raventós, Miguel Delgado-Rodríguez, Albert Sanllorente, Eugenio Cases-Pérez, Sara Castro-Barquero, Andrea Romanos-Nanclares, Olga Castañer, Antonio Garcia-Rios, and Rocío Barragán
Subjects: Male, evaluación del desenlace del paciente, Síndrome metabòlica, Mediterranean diet, 030309 nutrition & dietetics, humanos, stilbenes, Diet, Mediterranean, Body Mass Index, chemistry.chemical_compound, 0302 clinical medicine, Public Health Surveillance, Food science, Compostos bioactius, mediana edad, 2. Zero hunger, Metabolic Syndrome, anciano, 0303 health sciences, education.field_of_study, Nutrition and Dietetics, dieta, food and beverages, colesterol, Middle Aged, Metabolic syndrome, HDL-cholesterol, Cholesterol, Polifenols, Female, Colesterol, lcsh:Nutrition. Foods and food supply, Population, Dietética y nutrición, 030209 endocrinology & metabolism, lcsh:TX341-641, Dietary Polyphenol, Bioactive compounds, Article, 03 medical and health sciences, Mediterranean cooking, Cuina mediterrània, medicine, Humans, vigilancia en salud pública, polifenoles, education, Nutrició, Nutrition, Aged, business.industry, índice de masa corporal, Cholesterol, HDL, Polyphenols, medicine.disease, Diet, Patient Outcome Assessment, Blood pressure, glignans, Cross-Sectional Studies, chemistry, Polyphenol, Dietary Supplements, business, Body mass index, Biomarkers, estudios transversales, Food Science
Abstract: Dietary polyphenol intake is associated with improvement of metabolic disturbances. The aims of the present study are to describe dietary polyphenol intake in a population with metabolic syndrome (MetS) and to examine the association between polyphenol intake and the components of MetS. This cross-sectional analysis involved 6633 men and women included in the PREDIMED (PREvenci&oacute, n con DIeta MEDiterranea-Plus) study. The polyphenol content of foods was estimated from the Phenol-Explorer 3.6 database. The mean of total polyphenol intake was 846 &plusmn, 318 mg/day. Except for stilbenes, women had higher polyphenol intake than men. Total polyphenol intake was higher in older participants (&gt, 70 years of age) compared to their younger counterparts. Participants with body mass index (BMI) &gt, 35 kg/m2 reported lower total polyphenol, flavonoid, and stilbene intake than those with lower BMI. Total polyphenol intake was not associated with a better profile concerning MetS components, except for high-density lipoprotein cholesterol (HDL-c), although stilbenes, lignans, and other polyphenols showed an inverse association with blood pressure, fasting plasma glucose, and triglycerides. A direct association with HDL-c was found for all subclasses except lignans and phenolic acids. To conclude, in participants with MetS, higher intake of several polyphenol subclasses was associated with a better profile of MetS components, especially HDL-c.
Published: 2020

33. Total and Subtypes of Dietary Fat Intake and its Association with Components of the Metabolic Syndrome in a Mediterranean Population at High Cardiovascular Risk

Author: Nerea Becerra-Tomás, Pilar Matía-Martín, María Rosa Bernal-López, José Lapetra, Miquel Fiol, Josep A. Tur, Dolores Corella, Miguel Ángel Martínez-González, José J. Gaforio, Lucas Tojal-Sierra, Almudena Sánchez-Villegas, Josep Vidal, Maria Dolors Zomeño, Cristina Bouzas, Helmut Schröder, Estefanía Toledo, Vicente Martín-Sánchez, Itziar Abete, PREDIMED-Plus Investigators, Jordi Salas-Salvadó, Rosa Casas, J. Alfredo Martínez, Alicia Julibert, Nancy Babio, Carolina Sorto-Sánchez, Jose Lopez-Miranda, Francisco J. Tinahones, Olga Portolés, E. Ros, Karla Alejandra Pérez-Vega, Laura García-Molina, Sonia Eguaras, Montserrat Fitó, Xavier Pintó, Julia Wärnberg, Laura Barrubés, Dora Romaguera, Lidia Daimiel, Maria del Mar Bibiloni, Ana Galera, Domingo Orozco-Beltrán, Laura Torres-Collado, Rosa Carabaño-Moral, Ramon Estruch, Jesús Vioque, Oscar Coltell, Miguel Ruiz-Canela, Luis Serra-Majem, Lucía Ugarriza, José Manuel Santos-Lozano, Clotilde Vázquez, Jadwiga Konieczna, and Ángel M. Alonso-Gómez
Subjects: Blood Glucose, Male, Mediterranean diet, humanos, Physiology, Àcids grassos, 030204 cardiovascular system & hematology, Overweight, Diet, Mediterranean, chemistry.chemical_compound, 0302 clinical medicine, Risk Factors, evaluación de riesgos, Medicine, 030212 general & internal medicine, mediana edad, lípidos, 2. Zero hunger, chemistry.chemical_classification, Metabolic Syndrome, education.field_of_study, anciano, Nutrition and Dietetics, dieta, resultado del tratamiento, food and beverages, Middle Aged, Lipids, cardiovascular disease risk, 3. Good health, fat intake, Treatment Outcome, Cardiovascular Diseases, dietary fat, Obesitat, Female, medicine.symptom, lcsh:Nutrition. Foods and food supply, Polyunsaturated fatty acid, glucosa sanguínea, Mediterranean diet, cardiovascular disease risk, dietary fat, fat intake, fatty acids, Linoleic acid, Population, dislipidemias, enfermedades cardiovasculares, lcsh:TX341-641, Risk Assessment, fatty acids, Article, 03 medical and health sciences, grasas dietéticas, Mediterranean cooking, Ciencias de la Salud::Medicina preventiva [Materias Investigacion], Cuina mediterrània, factores de riesgo, Humans, Obesity, cardiovascular diseases, education, hiperglucemia, Aged, Dyslipidemias, business.industry, Malalties cardiovasculars, Hypertriglyceridemia, medicine.disease, Dietary Fats, Diet, Cross-Sectional Studies, chemistry, Spain, Hyperglycemia, Metabolic syndrome, business, Biomarkers, Food Science, estudios transversales
Abstract: Background: The effect of dietary fat intake on the metabolic syndrome (MetS) and in turn on cardiovascular disease (CVD) remains unclear in individuals at high CVD risk. Objective: To assess the association between fat intake and MetS components in an adult Mediterranean population at high CVD risk. Design: Baseline assessment of nutritional adequacy in participants (n = 6560, men and women, 55&ndash, 75 years old, with overweight/obesity and MetS) in the PREvenci&oacute, n con DIeta MEDiterr&aacute, nea (PREDIMED)-Plus randomized trial. Methods: Assessment of fat intake (total fat, monounsatured fatty acids: MUFA, polyunsaturated fatty acids: PUFA, saturated fatty acids: SFA, trans-fatty acids: trans-FA, linoleic acid, &alpha, linolenic acid, and &omega, 3 FA) using a validated food frequency questionnaire, and diet quality using 17-item Mediterranean dietary questionnaire and fat quality index (FQI). Results: Participants in the highest quintile of total dietary fat intake showed lower intake of energy, carbohydrates, protein and fiber, but higher intake of PUFA, MUFA, SFA, TFA, LA, ALA and &omega, 3 FA. Differences in MetS components were found according to fat intake. Odds (5th vs. 1st quintile): hyperglycemia: 1.3&ndash, 1.6 times higher for total fat, MUFA, SFA and &omega, 3 FA intake, low high-density lipoprotein cholesterol (HDL-c): 1.2 higher for LA, hypertriglyceridemia: 0.7 lower for SFA and &omega, 3 FA intake. Conclusions: Dietary fats played different role on MetS components of high CVD risk patients. Dietary fat intake was associated with higher risk of hyperglycemia.
Published: 2019
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34. Are Dietary Indices Associated with Polycystic Ovary Syndrome and Its Phenotypes? A Preliminary Study

Author: Julián J. Arense-Gonzalo, Ana Cutillas-Tolín, Evdochia Adoamnei, Jaime Mendiola, Alberto M. Torres-Cantero, Fuensanta Navarro-Lafuente, María Luisa Sánchez-Ferrer, Ana Carmona-Barnosi, Jesús Vioque, and María T. Prieto-Sánchez
Subjects: Adult, endocrine system diseases, Dietary Approaches To Stop Hypertension, Physiology, lcsh:TX341-641, 030209 endocrinology & metabolism, Physical exercise, Diet, Mediterranean, Logistic regression, Article, Body Mass Index, hyperandrogenism, Young Adult, alternate healthy index (AHEI), 03 medical and health sciences, 0302 clinical medicine, Dash, Humans, Medicine, polycystic ovary syndrome (PCOS), Mediterranean diet score (MDS), 030219 obstetrics & reproductive medicine, Nutrition and Dietetics, business.industry, Polycystic ovary syndrome (PCOS), Hyperandrogenism, PCOS phenotypes, Odds ratio, medicine.disease, Polycystic ovary, female genital diseases and pregnancy complications, Confidence interval, Rotterdam criteria, Logistic Models, Phenotype, Treatment Outcome, Spain, Case-Control Studies, Multivariate Analysis, alternate healthy index 2010 (AHEI-2010) and DASH index, Female, Diet, Healthy, business, lcsh:Nutrition. Foods and food supply, Polycystic Ovary Syndrome, Food Science
Abstract: Polycystic ovary syndrome (PCOS) is a complex hormonal disorder which impairs ovarian function. The adherence to healthy dietary patterns and physical exercise are the first line of recommended treatment for PCOS patients, but it is yet unclear what type of diet is more adequate. In this case-control study, we explored associations between adherence to five dietary quality indices and the presence of PCOS. We enrolled 126 cases of PCOS and 159 controls living in Murcia (Spain). Diagnostic of PCOS and its phenotypes were established following the Rotterdam criteria (hyperandrogenism (H), oligoanovulation (O), polycystic ovaries morphology (POM)). We used a validated food frequency questionnaires to calculate the scores of five dietary indices: alternate Healthy Eating index (AHEI), AHEI-2010, relative Mediterranean Dietary Score (rMED), alternate Mediterranean Dietary Score (aMED) and Dietary Approaches to Stop Hypertension (DASH). We used multivariable logistic regression to estimate adjusted odds ratios and confidence intervals. In the multivariable analysis, AHEI-2010 index was inversely associated with Hyperandrogenism + Oligoanovulation PCOS phenotype (ORQ3 vs. Q1 = 0.1, 95% CI: (0.0, 0.9), Pfor trend = 0.02). We did not find any statistical significant association between dietary indices and total anovulatory or ovulatory PCOS. However, further studies with higher sample sizes exploring these associations among the diverse phenotypes of PCOS are highly warranted.
Published: 2021
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35. Dietary Polyphenol Intake is Associated with HDL-Cholesterol and A Better Profile of other Components of the Metabolic Syndrome: A PREDIMED-Plus Sub-Study

Author: Castro-Barquero, Sara, primary, Tresserra-Rimbau, Anna, additional, Vitelli-Storelli, Facundo, additional, Doménech, Mónica, additional, Salas-Salvadó, Jordi, additional, Martín-Sánchez, Vicente, additional, Rubín-García, María, additional, Buil-Cosiales, Pilar, additional, Corella, Dolores, additional, Fitó, Montserrat, additional, Romaguera, Dora, additional, Vioque, Jesús, additional, Alonso-Gómez, Ángel, additional, Wärnberg, Julia, additional, Martínez, José, additional, Serra-Majem, Luís, additional, Tinahones, Francisco, additional, Lapetra, José, additional, Pintó, Xavier, additional, Tur, Josep, additional, Garcia-Rios, Antonio, additional, García-Molina, Laura, additional, Delgado-Rodriguez, Miguel, additional, Matía-Martín, Pilar, additional, Daimiel, Lidia, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Cofán, Montserrat, additional, Romanos-Nanclares, Andrea, additional, Becerra-Tomas, Nerea, additional, Barragan, Rocio, additional, Castañer, Olga, additional, Konieczna, Jadwiga, additional, González-Palacios, Sandra, additional, Sorto-Sánchez, Carolina, additional, Pérez-López, Jessica, additional, Zulet, María, additional, Bautista-Castaño, Inmaculada, additional, Casas, Rosa, additional, Gómez-Perez, Ana, additional, Santos-Lozano, José, additional, Rodríguez-Sanchez, María, additional, Julibert, Alicia, additional, Martín-Calvo, Nerea, additional, Hernández-Alonso, Pablo, additional, Sorlí, José, additional, Sanllorente, Albert, additional, Galmés-Panadés, Aina, additional, Cases-Pérez, Eugenio, additional, Goicolea-Güemez, Leire, additional, Ruiz-Canela, Miguel, additional, Babio, Nancy, additional, Hernáez, Álvaro, additional, Lamuela-Raventós, Rosa, additional, and Estruch, Ramon, additional
Published: 2020
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36. Seafood Consumption, Omega-3 Fatty Acids Intake, and Life-Time Prevalence of Depression in the PREDIMED-Plus Trial

Author: Miguel A. Muñoz, Estefanía Toledo, Dolores Corella, Josep Vidal, Itziar Abete, Andrés Díaz-López, Manoli García de la Hera, Manuel Ortega-Calvo, Clotilde Vázquez, Emilio Ros, Lidia Daimiel, Aurora Bueno-Cavanillas, Vicente Martín, Nancy Babio, Josep A. Tur, Miguel Ruiz-Canela, Jacqueline Álvarez-Pérez, J. A. Martínez, Carolina Ortega-Azorín, Jessica Pérez-López, Oscar Lecea, Xavier Pintó, María Dolores Zomeño, Marisol Izquierdo, Lluis Serra-Majem, Jordi Salas-Salvadó, Montserrat Fitó, Ramon Estruch, Jesús Vioque, Jose Lopez-Miranda, Miguel Delgado-Rodríguez, Miguel Ángel Martínez-González, Pilar Matía, F. Aros, Francisco Tinahones, Almudena Sánchez-Villegas, Dora Romaguera, and Antonio Garcia-Rios
Subjects: 0301 basic medicine, Male, eicosapentaenoic acid, modelos logísticos, humanos, depresión, encuestas sobre dietas, 0302 clinical medicine, Clinical trials, Surveys and Questionnaires, Odds Ratio, Prevalence, 030212 general & internal medicine, Depressió psíquica, mediana edad, Dietoteràpia, 2. Zero hunger, anciano, Nutrition and Dietetics, integumentary system, dieta, Depression, European research, Fatty Acids, prevalencia, Fishes, food and beverages, Middle Aged, docosahexaenoic acid, cociente de probabilidades relativas, Mental depression, depression, Christian ministry, Female, omega-3, lcsh:Nutrition. Foods and food supply, European Regional Development Fund, lcsh:TX341-641, Àcids grassos omega-3, Diet Surveys, Article, 03 medical and health sciences, alimentos del mar, Depression (economics), peces, trastorno depresivo, Environmental health, Political science, Fatty Acids, Omega-3, ingesta energética, Omega-3 fatty acids, Animals, Humans, ácidos grasos, Aged, Consumption (economics), fish, conducta alimentaria, Depressive Disorder, 030109 nutrition & dietetics, Diet therapy, Life time, Feeding Behavior, Predimed, Diet, Cross-Sectional Studies, Logistic Models, Seafood, animales, Energy Intake, Food Science, estudios transversales, Assaigs clínics
Abstract: Background: The aim of this analysis was to ascertain the type of relationship between fish and seafood consumption, omega-3 polyunsaturated fatty acids (&omega, 3 PUFA) intake, and depression prevalence. Methods: Cross-sectional analyses of the PREDIMED-Plus trial. Fish and seafood consumption and &omega, 3 PUFA intake were assessed through a validated food-frequency questionnaire. Self-reported life-time medical diagnosis of depression or use of antidepressants was considered as outcome. Depressive symptoms were collected by the Beck Depression Inventory-II. Logistic regression models were used to estimate the association between seafood products and &omega, 3 PUFA consumption and depression. Multiple linear regression models were fitted to assess the association between fish and long-chain (LC) &omega, 3 PUFA intake and depressive symptoms. Results: Out of 6587 participants, there were 1367 cases of depression. Total seafood consumption was not associated with depression. The odds ratios (ORs) (95% confidence intervals (CIs)) for the 2nd, 3rd, and 4th quintiles of consumption of fatty fish were 0.77 (0.63&ndash, 0.94), 0.71 (0.58&ndash, 0.87), and 0.78 (0.64&ndash, 0.96), respectively, and p for trend = 0.759. Moderate intake of total LC &omega, 3 PUFA (approximately 0.5&ndash, 1 g/day) was significantly associated with a lower prevalence of depression. Conclusion: In our study, moderate fish and LC &omega, 3 PUFA intake, but not high intake, was associated with lower odds of depression suggesting a U-shaped relationship.
Published: 2018

37. Association of Iron Status and Intake During Pregnancy with Neuropsychological Outcomes in Children Aged 7 Years: The Prospective Birth Cohort Infancia y Medio Ambiente (INMA) Study

Author: Arija, Victoria, primary, Hernández-Martínez, Carmen, additional, Tous, Mónica, additional, Canals, Josefa, additional, Guxens, Mónica, additional, Fernández-Barrés, Silvia, additional, Ibarluzea, Jesús, additional, Babarro, Izaro, additional, Soler-Blasco, Raquel, additional, Llop, Sabrina, additional, Vioque, Jesús, additional, Sunyer, Jordi, additional, and Julvez, Jordi, additional
Published: 2019
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38. Sugar-Containing Beverages Consumption and Obesity in Children Aged 4–5 Years in Spain: the INMA Study

Author: Gonzalez-Palacios, Sandra, primary, Navarrete-Muñoz, Eva-María, additional, García-de-la-Hera, Manoli, additional, Torres-Collado, Laura, additional, Santa-Marina, Loreto, additional, Amiano, Pilar, additional, Lopez-Espinosa, Maria-Jose, additional, Tardon, Adonina, additional, Riano-Galan, Isolina, additional, Vrijheid, Martine, additional, Sunyer, Jordi, additional, and Vioque, Jesus, additional
Published: 2019
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39. Total and Subtypes of Dietary Fat Intake and Its Association with Components of the Metabolic Syndrome in a Mediterranean Population at High Cardiovascular Risk

Author: Julibert, Alicia, primary, Bibiloni, Maria, additional, Bouzas, Cristina, additional, Martínez-González, Miguel, additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Zomeño, Maria, additional, Romaguera, Dora, additional, Vioque, Jesús, additional, Alonso-Gómez, Ángel, additional, Wärnberg, Julia, additional, Martínez, J., additional, Serra-Majem, Luís, additional, Estruch, Ramon, additional, Tinahones, Francisco, additional, Lapetra, José, additional, Pintó, Xavier, additional, Lopez-Miranda, José, additional, García-Molina, Laura, additional, Gaforio, José, additional, Matía-Martín, Pilar, additional, Daimiel, Lidia, additional, Martín-Sánchez, Vicente, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Ros, Emili, additional, Toledo, Estefanía, additional, Becerra-Tomás, Nerea, additional, Pórtoles, Olga, additional, Pérez-Vega, Karla, additional, Fiol, Miquel, additional, Torres-Collado, Laura, additional, Tojal-Sierra, Lucas, additional, Carabaño-Moral, Rosa, additional, Abete, Itziar, additional, Sanchez-Villegas, Almudena, additional, Casas, Rosa, additional, Bernal-López, María, additional, Santos-Lozano, José, additional, Galera, Ana, additional, Ugarriza, Lucía, additional, Ruiz-Canela, Miguel, additional, Babio, Nancy, additional, Coltell, Oscar, additional, Schröder, Helmut, additional, Konieczna, Jadwiga, additional, Orozco-Beltrán, Domingo, additional, Sorto-Sánchez, Carolina, additional, Eguaras, Sonia, additional, Barrubés, Laura, additional, Fitó, Montserrat, additional, Tur, Josep, additional, and Investigators, PREDIMED-PLUS, additional
Published: 2019
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40. Dietary Diversity and Nutritional Adequacy among an Older Spanish Population with Metabolic Syndrome in the PREDIMED-Plus Study: A Cross-Sectional Analysis

Author: Cano-Ibáñez, Naomi, primary, Gea, Alfredo, additional, Martínez-González, Miguel A., additional, Salas-Salvadó, Jordi, additional, Corella, Dolores, additional, Zomeño, M. Dolors, additional, Romaguera, Dora, additional, Vioque, Jesús, additional, Aros, Fernando, additional, Wärnberg, Julia, additional, Martínez, J. Alfredo, additional, Serra-Majem, Lluis, additional, Estruch, Ramón, additional, Tinahones, Francisco J., additional, Lapetra, José, additional, Pintó, Xavier, additional, Tur, Josep A., additional, García-Ríos, Antonio, additional, Riquelme-Gallego, Blanca, additional, Delgado-Rodríguez, Miguel, additional, Matía, Pilar, additional, Daimiel, Lidia, additional, Martín, Vicente, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Ros, Emilio, additional, Buil-Cosiales, Pilar, additional, Díaz-López, Andrés, additional, Fernández-Carrión, Rebeca, additional, Fitó, Montserrat, additional, Konieczna, Jadwiga, additional, Notario-Barandiaran, Leyre, additional, Alonso-Gómez, Ángel M., additional, Contreras-Fernández, Eugenio, additional, Abete, Itziar, additional, Sánchez-Villegas, Almudena, additional, Casas, Rosa, additional, Muñoz-Garach, Araceli, additional, Santos-Lozano, José Manuel, additional, Gallardo-Alfaro, Laura, additional, Basora, Josep, additional, Portoles, Olga, additional, Muñoz, Miguel Ángel, additional, Moñino, Manuel, additional, Miralles Gisbert, Salvador Miralles, additional, Rodríguez, Anai Moreno, additional, Ruiz-Canela, Miguel, additional, Palau Galindo, Antoni Palau, additional, Pérez-Vega, Karla Alejandra, additional, and Bueno-Cavanillas, Aurora, additional
Published: 2019
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41. Reproducibility and Validity of a Short Food Frequency Questionnaire for Dietary Assessment in Children Aged 7–9 Years in Spain

Author: Vioque, Jesus, primary, Garcia-de-la-Hera, Manuela, additional, Gonzalez-Palacios, Sandra, additional, Torres-Collado, Laura, additional, Notario-Barandiaran, Leyre, additional, Oncina-Canovas, Alejandro, additional, Soler-Blasco, Raquel, additional, Lozano, Manuel, additional, Beneito, Andrea, additional, and Navarrete-Muñoz, Eva-Maria, additional
Published: 2019
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42. Sleep Duration is Inversely Associated with Serum Uric Acid Concentrations and Uric Acid to Creatinine Ratio in an Elderly Mediterranean Population at High Cardiovascular Risk

Author: Papandreou, Christopher, primary, Babio, Nancy, additional, Díaz-López, Andrés, additional, Martínez-González, Miguel, additional, Becerra-Tomas, Nerea, additional, Corella, Dolores, additional, Schröder, Helmut, additional, Romaguera, Dora, additional, Vioque, Jesús, additional, Alonso-Gómez, Ángel, additional, Wärnberg, Julia, additional, Martínez, Alfredo, additional, Serra-Majem, Lluís, additional, Estruch, Ramon, additional, Muñoz-Garach, Araceli, additional, Lapetra, José, additional, Pintó, Xavier, additional, Tur, Josep, additional, Garcia-Rios, Antonio, additional, Bueno-Cavanillas, Aurora, additional, Delgado-Rodríguez, Miguel, additional, Matía-Martín, Pilar, additional, Daimiel, Lidia, additional, Martín-Sánchez, Vicente, additional, Vidal, Josep, additional, Vázquez, Clotilde, additional, Ros, Emilio, additional, Ruiz-Canela, Miguel, additional, Bulló, Mónica, additional, Sorli, Jose, additional, Quifer, Mireia, additional, Colom, Antoni, additional, Oncina-Canovas, Alejandro, additional, Tojal-Sierra, Lucas, additional, Barón-López, Javier, additional, Pérez-Farinós, Napoleón, additional, Abete, Itziar, additional, Sanchez-Villegas, Almudena, additional, Casas, Rosa, additional, Fernández-Garcia, José, additional, Santos-Lozano, José, additional, Corbella, Emili, additional, del M. Bibiloni, Maria, additional, Diez-Espino, Javier, additional, Asensio, Eva, additional, Torras, Laura, additional, Morey, Marga, additional, Compañ-Gabucio, Laura, additional, Salaverria-Lete, Itziar, additional, Cenoz-Osinaga, Juan, additional, Castañer, Olga, additional, and Salas-Salvadó, Jordi, additional
Published: 2019
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43. Reproducibility and Validity of a Short Food Frequency Questionnaire for Dietary Assessment in Children Aged 7–9 Years in Spain

Author: Sandra Gonzalez-Palacios, Andrea Beneito, Laura Torres-Collado, Raquel Soler-Blasco, Manuela García-de-la-Hera, Manuel Lozano, Alejandro Oncina-Canovas, Leyre Notario-Barandiaran, Eva-María Navarrete-Muñoz, and Jesús Vioque
Subjects: Male, 0301 basic medicine, validity, Dietary assessment, food frequency questionnaire, medicine.medical_treatment, alpha-Tocopherol, lcsh:TX341-641, 030209 endocrinology & metabolism, Nutrient intake, Article, Cohort Studies, Food group, 03 medical and health sciences, 0302 clinical medicine, Nutrient, 24-hour dietary recall, Mediterranean country, childhood, diet, food frequency questionnaire, nutrient intake, nutritional biomarker, reproducibility, validity, Surveys and Questionnaires, Environmental health, Humans, Medicine, Vitamin D, Child, reproducibility, childhood, nutritional biomarker, 24-hour dietary recall, Reproducibility, 030109 nutrition & dietetics, Nutrition and Dietetics, nutrient intake, business.industry, Vitamin E, food and beverages, Reproducibility of Results, Food frequency questionnaire, Carotenoids, Diet, Nutrition Assessment, Blood chemistry, Spain, Mediterranean country, Female, diet, Energy Intake, Epidemiologic Methods, business, lcsh:Nutrition. Foods and food supply, Food Science
Abstract: The purpose of this study was to examine if the short semi-quantitative food frequency questionnaire (FFQ) is a reliable and valid tool to assess the diet of Spanish children aged 7&ndash, 9 years. We collected data from 156 children of the birth cohort INMA (Infancia y Medio Ambiente (Environment and Childhood)). Children&rsquo, s parents or care-givers completed a 46-item FFQ on two occasions over a 9&ndash, 12-month period about the children&rsquo, s diet. To explore the reproducibility of the FFQ, the nutrient and food group intake collected from the both FFQs were compared, while validity was examined by contrasting the nutrient values from the FFQs and the average of three 24-hour dietary recalls (24hDRs) taken in this period, and also with the concentration of several vitamins in the blood (carotenoids, vitamin D and &alpha, tocopherol). Pearson and de-attenuated correlation coefficients were calculated. The average correlation coefficients for nutrient intake&rsquo, s reproducibility was 0.41, ranging from 0.25 (calcium) to 0.65 (&beta, carotene), and for food group intake was 0.45, ranging from 0.18 (cereals) to 0.68 (sweetened beverages). Correlation coefficients slightly improved when we compared energy-adjusted intakes. The average correlation coefficients for validity against 24hDRs was 0.34 for energy-adjusted intakes, and 0.39 when de-attenuation coefficients were used. The validity coefficients against the blood concentrations of vitamins were 0.38 for &beta, cryptoxanthin, 0.26 for lycopene, 0,23 for &alpha, carotene and 0.15 for &beta, carotene, all of them statistically significant (p &lt, 0.05). This study suggests that our brief FFQ is a suitable tool for the dietary assessment of a wide range of nutrients and food groups in children 7&ndash, 9 years, despite the low to moderate reproducibility and validity observed for some nutrients.
Published: 2019
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44. Nut Consumptions as a Marker of Higher Diet Quality in a Mediterranean Population at High Cardiovascular Risk

Author: Bibiloni, Maria, primary, Julibert, Alicia, additional, Bouzas, Cristina, additional, Martínez-González, Miguel, additional, Corella, Dolores, additional, Salas-Salvadó, Jordi, additional, Zomeño, M., additional, Vioque, Jesús, additional, Romaguera, Dora, additional, Martínez, J., additional, Wärnberg, Julia, additional, López-Miranda, José, additional, Estruch, Ramón, additional, Bueno-Cavanillas, Aurora, additional, Arós, Fernando, additional, Tinahones, Francisco, additional, Serra-Majem, Lluis, additional, Martín, Vicente, additional, Lapetra, José, additional, Vázquez, Clotilde, additional, Pintó, Xavier, additional, Vidal, Josep, additional, Daimiel, Lidia, additional, Delgado-Rodríguez, Miguel, additional, Matía, Pilar, additional, Ros, Emilio, additional, Fernández-Carrión, Rebeca, additional, Garcia-Rios, Antonio, additional, Zulet, M., additional, Orozco-Beltrán, Domingo, additional, Schröder, Helmut, additional, Fitó, Montserrat, additional, Bulló, Mónica, additional, Basora, Josep, additional, Cenoz, Juan, additional, Diez-Espino, Javier, additional, Toledo, Estefanía, additional, and Tur, Josep, additional
Published: 2019
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45. Seafood Consumption, Omega-3 Fatty Acids Intake, and Life-Time Prevalence of Depression in the PREDIMED-Plus Trial

Author: Sánchez-Villegas, Almudena, primary, Álvarez-Pérez, Jacqueline, additional, Toledo, Estefanía, additional, Salas-Salvadó, Jordi, additional, Ortega-Azorín, Carolina, additional, Zomeño, Maria, additional, Vioque, Jesús, additional, Martínez, Jose, additional, Romaguera, Dora, additional, Pérez-López, Jessica, additional, López-Miranda, José, additional, Estruch, Ramón, additional, Bueno-Cavanillas, Aurora, additional, Arós, Fernando, additional, Tur, Josep, additional, Tinahones, Francisco, additional, Lecea, Oscar, additional, Martín, Vicente, additional, Ortega-Calvo, M., additional, Vázquez, Clotilde, additional, Pintó, Xavier, additional, Vidal, Josep, additional, Daimiel, Lidia, additional, Delgado-Rodríguez, Miguel, additional, Matía, Pilar, additional, Corella, Dolores, additional, Díaz-López, Andrés, additional, Babio, Nancy, additional, Muñoz, Miguel, additional, Fitó, Montserrat, additional, García de la Hera, Manoli, additional, Abete, Itziar, additional, García-Rios, Antonio, additional, Ros, Emilio, additional, Ruíz-Canela, Miguel, additional, Martínez-González, Miguel, additional, Izquierdo, Marisol, additional, and Serra-Majem, Lluis, additional
Published: 2018
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46. Dietary Intake of Trans Fatty Acids in Children Aged 4–5 in Spain: The INMA Cohort Study

Author: Scholz, Alexander, primary, Gimenez-Monzo, Daniel, additional, Navarrete-Muñoz, Eva, additional, Garcia-de-la-Hera, Manuela, additional, Fernandez-Somoano, Ana, additional, Tardon, Adonina, additional, Santa Marina, Loreto, additional, Irazabal, Amaia, additional, Romaguera, Dora, additional, Guxens, Mònica, additional, Julvez, Jordi, additional, Llop, Sabrina, additional, Lopez-Espinosa, Maria-Jose, additional, and Vioque, Jesus, additional
Published: 2016
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47. Adherence to the Mediterranean Diet and Determinants Among Pregnant Women: The NELA Cohort.

Author: Suárez-Martínez, Clara, Yagüe-Guirao, Genoveva, Santaella-Pascual, Marina, Peso-Echarri, Patricia, Vioque, Jesús, Morales, Eva, García-Marcos, Luis, Martínez-Graciá, Carmen, and Montalcini, Tiziana
Abstract: The Mediterranean diet represents one of the most studied dietary patterns; however, there is no single tool for measuring the grade of adherence and no single set of criteria for adapting these indices to pregnant women. We characterized the adherence to the Mediterranean diet (MDA) of pregnant women participating in the NELA (Nutrition in Early Life and Asthma) cohort and identified the sociodemographic determinants and lifestyle habits associated with a higher risk of a low MDA. Maternal diet during gestation was assessed by a validated Food Frequency Questionnaire (FFQ) (n = 665). We estimated the Relative Mediterranean Diet score (rMED), Alternative Mediterranean Diet score (aMED), and the Alternate Healthy Eating Index-2010 (AHEI-2010). Multivariate regression models were performed to identify the sociodemographic and lifestyle factors associated with each index. Mothers with a lower age and more previous deliveries had a greater probability of low MDA (p < 0.05). For the aMED index only, mothers with university education and/or who practiced sport activities for two or more hours per week had a lower probability of a low MDA (p < 0.01). The three indices classified the NELA cohort as having a medium level of adherence. These results may be improved by designing intervention strategies and dietary recommendations for both maternal and offspring health. [ABSTRACT FROM AUTHOR]
Published: 2021
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48. Associations between Age-Related Hearing Loss and Dietary Assessment Using Data from Korean National Health and Nutrition Examination Survey.

Author: Choi, Ji Eun, Ahn, Jungmin, Moon, Il Joon, and Vioque, Jesus
Abstract: Age-related hearing loss (ARHL) is a major and rapidly growing public health problem that causes disability, social isolation, and socioeconomic cost. Nutritional status is known to cause many aging-related problems, and recent studies have suggested that there are interaction effects between ARHL and dietary factors. We aimed to investigate the association between ARHL and dietary assessment using data from the fifth Korean National Health and Nutrition Examination Survey, which is a nationwide cross-sectional survey that included 5201 participants aged ≥50 years from 2010 to 2012. All participants had normal findings on otoscopic examination and symmetric hearing thresholds of <15 dB between both sides. Nutritional survey data included food consumption and nutrient intake using the 24 h recall method. Data were analyzed using multiple regression models with complex sampling adjusted for confounding factors, such as age, sex, educational level, and history of diabetes. Higher intake of seeds and nuts, fruits, seaweed, and vitamin A were positively associated with better hearing. Our findings suggest that dietary antioxidants or anti-inflammatory food may help reduce ARHL. [ABSTRACT FROM AUTHOR]
Published: 2021
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49. Self-Reported DHA Supplementation during Pregnancy and Its Association with Obesity or Gestational Diabetes in Relation to DHA Concentration in Cord and Maternal Plasma: Results from NELA, a Prospective Mother-Offspring Cohort.

Author: Gázquez, Antonio, Giménez-Bañón, María J., Prieto-Sánchez, María T., Martínez-Graciá, Carmen, Suárez, Clara, Santaella-Pascual, Marina, Galdo-Castiñeira, Lina, Ballesteros-Meseguer, Carmen, Vioque, Jesús, Martínez-Villanueva, Miriam, Avilés-Plaza, Francisco, Noguera-Velasco, José A., Morales, Eva, García-Marcos, Luís, Larqué, Elvira, and Campoy, Cristina
Abstract: Maternal supplementation of docosahexaenoic acid (DHA) during pregnancy has been recommended due to its role in infant development, but its effect on materno-fetal DHA status is not well established. We evaluated the associations between DHA supplementation in pregnant women with obesity or gestational diabetes mellitus (GDM) and maternal and neonatal DHA status. Serum fatty acids (FA) were analyzed in 641 pregnant women (24 weeks of gestation) and in 345 venous and 166 arterial cord blood samples of participants of the NELA cohort. Obese women (n = 47) presented lower DHA in serum than those lean (n = 397) or overweight (n = 116) before pregnancy. Linoleic acid in arterial cord was elevated in obese women, which indicates lower fetal retention. Maternal DHA supplementation (200 mg/d) during pregnancy was associated with enhanced maternal and fetal DHA levels regardless of pre-pregnancy body mass index (BMI), although higher arterial DHA in overweight women indicated an attenuated response. Maternal DHA supplementation was not associated with cord venous DHA in neonates of mothers with GDM. The cord arteriovenous difference was similar for DHA between GDM and controls. In conclusion, maternal DHA supplementation during pregnancy enhanced fetal DHA status regardless of the pre-pregnancy BMI while GDM may reduce the effect of DHA supplementation in newborns. [ABSTRACT FROM AUTHOR]
Published: 2021
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