1. Glycomacropeptide Bioactivity and Health: A Review Highlighting Action Mechanisms and Signaling Pathways
- Author
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Mariela Jiménez, Laura E. Córdova-Dávalos, and Eva Salinas
- Subjects
action mechanisms ,0301 basic medicine ,lcsh:TX341-641 ,Review ,Computational biology ,Biology ,03 medical and health sciences ,Human health ,Biological property ,Humans ,glycomacropeptide ,030109 nutrition & dietetics ,Nutrition and Dietetics ,milk-derived bioactive peptide ,Caseins ,Peptide Fragments ,antibacterial ,030104 developmental biology ,Action (philosophy) ,prebiotic ,remineralizing ,anti-tumoral ,Signal transduction ,metabolism ,lcsh:Nutrition. Foods and food supply ,Food Analysis ,Metabolic Networks and Pathways ,immuno-modulatory ,Food Science - Abstract
Food-derived bioactive peptides are reported as beneficial and safe for human health. Glycomacropeptide (GMP) is a milk-protein-derived peptide that, in addition to its nutritional value, retains many biological properties and has therapeutic effects in several inflammatory disorders. GMP was shown under in vitro and in vivo conditions to exert a number of activities that regulate the physiology of important body systems, namely the gastrointestinal, endocrine, and immune systems. This review represents a comprehensive compilation summarizing the current knowledge and updated information on the major biological properties associated with GMP. GMP bioactivity is addressed with special attention on mechanisms of action, signaling pathways involved, and structural characteristics implicated. In addition, the results of various studies dealing with the effects of GMP on models of inflammatory diseases are reviewed and discussed.
- Published
- 2019
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