1. White blood cell count may identify abnormal cardiometabolic phenotype and preclinical organ damage in overweight/obese children
- Author
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Di Bonito, P., Pacifico, L., Chiesa, C., Invitti, C., Miraglia Del Giudice, E., Baroni, M. G., Moio, N., Pellegrin, M. C., Tomat, M., Licenziati, M. R., Manco, M., Maffeis, C., Valerio, G., Gilardini, L., Sanguigno, E., Driul, D., Grandone, A., Incani, M., Morandi, A., Tornese, G., Di Bonito, P., Pacifico, L., Chiesa, C., Invitti, C., Miraglia Del Giudice, E., Baroni, M. G., Moio, N., Pellegrin, M. C., Tomat, M., Licenziati, M. R., Manco, Maria, Maffeis, C., Valerio, G., Gilardini, L., Sanguigno, E., Driul, D., Grandone, A., Incani, M., Morandi, A., Tornese, G., and Manco, M.
- Subjects
Blood Glucose ,Male ,Pediatric Obesity ,Endocrinology, Diabetes and Metabolism ,Left ,Medicine (miscellaneous) ,Predictive Value of Test ,030204 cardiovascular system & hematology ,Overweight ,Carotid Intima-Media Thickness ,Ventricular Function, Left ,Leukocyte Count ,0302 clinical medicine ,Endocrinology ,Retrospective Studie ,Risk Factors ,Cardiovascular Disease ,Nutrition and Dietetic ,Prevalence ,Medicine ,Preclinical signs of organ damage ,Ventricular Function ,Age Factor ,Child ,Waist-to-height ratio ,Metabolic Syndrome ,Nutrition and Dietetics ,Cardiometabolic risk factors ,Overweight/obese children ,White blood cell count ,Diabetes and Metabolism ,Cardiology and Cardiovascular Medicine ,biology ,Ventricular Remodeling ,Liver Disease ,Metabolic Syndrome X ,Liver Diseases ,Age Factors ,Alanine Transaminase ,Phenotype ,Italy ,Cardiovascular Diseases ,Cardiology ,Homeostatic model assessment ,Female ,medicine.symptom ,Human ,medicine.medical_specialty ,Adolescent ,030209 endocrinology & metabolism ,03 medical and health sciences ,Insulin resistance ,Predictive Value of Tests ,Carotid Intima-Media Thickne ,Internal medicine ,Humans ,Biomarkers ,Cross-Sectional Studies ,Retrospective Studies ,Cross-Sectional Studie ,Cardiometabolic risk factor ,business.industry ,Risk Factor ,Biomarker ,medicine.disease ,Obesity ,Alanine transaminase ,biology.protein ,Metabolic syndrome ,business ,Body mass index - Abstract
Background and Aims Subclinical inflammation is a central component of cardiometabolic disease risk in obese subjects. The aim of the study was to evaluate whether the white blood cell count (WBCc) may help to identify an abnormal cardiometabolic phenotype in overweight (Ow) or obese (Ob) children. Methods and Results A cross-sectional sample of 2835 Ow/Ob children and adolescents (age 6–18 years) was recruited from 10 Italian centers for the care of obesity. Anthropometric and biochemical variables were assessed in the overall sample. Waist to height ratio (WhtR), alanine aminotransferase (ALT), lipids, 2 h post-load plasma glucose (2hPG), left ventricular (LV) geometry and carotid intima-media thickness (cIMT) were assessed in 2128, 2300, 1834, 535 and 315 children, respectively. Insulin resistance and whole body insulin sensitivity index (WBISI) were analyzed using homeostatic model assessment (HOMA-IR) and Matsuda's test. Groups divided in quartiles of WBCc significantly differed for body mass index, WhtR, 2hPG, HOMA-IR, WBISI, lipids, ALT, cIMT, LV mass and relative wall thickness. Children with high WBCc (≥8700 cell/mm 3 ) showed a 1.3–2.5 fold increased probability of having high normal 2hPG, high ALT, high cIMT, or LV remodeling/concentric LV hypertrophy, after adjustment for age, gender, pubertal status, BMI and centers. Conclusions This study shows that WBCc is associated with early derangements of glucose metabolism and preclinical signs of liver, vascular and cardiac damage. The WBCc may be an effective and low-cost tool for identifying Ow and Ob children at the greatest risk of potential complications.
- Published
- 2015