1. The Impact of Dietary Polyphenols on COX-2 Expression in Colorectal Cancer.
- Author
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Owczarek, Katarzyna and Lewandowska, Urszula
- Subjects
PREVENTION of chronic diseases ,INFLAMMATION prevention ,TUMOR prevention ,RECTUM tumors ,COLON tumor prevention ,ENZYME metabolism ,ARACHIDONIC acid ,DIET therapy for cancer patients ,CYTOKINES ,DIET ,GROWTH factors ,INTERLEUKINS ,NONSTEROIDAL anti-inflammatory agents ,POLYPHENOLS ,PROTEIN kinases ,TUMOR necrosis factors ,DNA-binding proteins ,CYCLOOXYGENASE 2 ,PHARMACODYNAMICS - Abstract
Polyphenols are natural compounds with high structural diversity whose common occurrence in plants renders them intrinsic dietary components. They are known to be secondary metabolites characterized by a wide spectrum of biological activities, and a growing body of evidence indicates they have anti-inflammatory potential. It is well known that inflammation plays a key role in many chronic diseases such as circulatory diseases, pulmonary diseases, autoimmune diseases, diabetes, cancer, and neurodegenerative diseases. Polyphenols influence the inflammatory process by controlling and inhibiting pro-inflammatory cytokines such as IL-1β, IL-6, IL-8, and TNF-α, and cyclooxygenase-2 (COX-2) enzyme involved in the metabolism of arachidonic acid. Furthermore, polyphenols exhibit anti-inflammatory activity on many levels via NF-κB inhibition, and MAPK, iNOS, and growth factors regulation. This paper reviews the current state of knowledge concerning the potential of various dietary polyphenols to inhibit the effects of COX-2 in colon cancer, by examining the available evidence regarding the efficacy and safety of these compounds obtained from in vitro and animal studies. [ABSTRACT FROM PUBLISHER]
- Published
- 2017
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