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Your search keyword '"Afshin Karami"' showing total 3 results
Start Over Author "Afshin Karami" Journal nutrition and cancer
3 results on '"Afshin Karami"'

1. Antiproliferative Effect of Gaillardin from Inula oculus-christi in Human Leukemic Cells

Author

Amir Yami, Ahmad Gharehbaghian, Afshin Karami, Mohieddin Barzegar, Maryam Hamzeloo-Moghadam, and Pargol Mashati

Subjects
0301 basic medicine, chemistry.chemical_classification, Cancer Research, 030109 nutrition & dietetics, Nutrition and Dietetics, Inula, biology, Traditional medicine, Chemistry, Natural compound, Medicine (miscellaneous), biology.organism_classification, Sesquiterpene lactone, Gaillardin, 03 medical and health sciences, 0302 clinical medicine, Oncology, 030220 oncology & carcinogenesis, Cancer cell, Inula oculus-christi, Antiproliferative effect, Cytotoxicity
Abstract

Gaillardin (GLN) is a sesquiterpene lactone isolated from the chloroform extract of Inula oculus-christi L. This natural compound has shown cytotoxicity in various cancerous cell line. However, its...

Published
2019
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2. Synergistic Effect of Gefitinib and Temozolomide on U87MG Glioblastoma Angiogenesis

Author

Ehsan Mohammadi Noori, Maryam Hossienpour, Afshin Karami, Khadijeh Najafi, Mehdi Rahpyma, and Amir Kiani

Subjects
Vascular Endothelial Growth Factor A, Cancer Research, Angiogenesis, Medicine (miscellaneous), Gefitinib, Cell Line, Tumor, medicine, Temozolomide, Humans, neoplasms, Antineoplastic Agents, Alkylating, Nutrition and Dietetics, Neovascularization, Pathologic, business.industry, Brain Neoplasms, Drug Synergism, Glioma, medicine.disease, nervous system diseases, Key factors, Oncology, Drug Resistance, Neoplasm, Cancer research, business, Glioblastoma, medicine.drug
Abstract

One of the most common and deadly brain tumors is Glioblastoma multiforme (GBM). Due to recent advances in angiogenesis and its related key factors, this process as a hallmark in glioblastoma has attracted more consideration from the research community. Temozolomide (TMZ) as the first-line treatment used to treat GBM but, resistance to TMZ limits its effectiveness and the need for better treatments is still felt. Therefore, we aimed to examine the Synergistic effects of Gefitinib (GFI) in combination with Temozolomide on VEGF and MMPs in glioma cell line (U87MG). Our results displayed that GFI could induce cytotoxic effects in U87MG with IC50 values of 11 μM. U87MG cells produced large amounts of VEGF without any stimuli, and the results showed that GFI in combination with TMZ caused a significant decrease in VEGF production in these cells. In this study, we demonstrated that after treating with TMZ and GFI, there was more decrease in the levels of MMP 2 and 9 secretions in cells than treatment with GFI and TMZ doses alone. This study indicates synergistic effects of GFI plus TMZ against glioma are mediated by the potentiated anti-angiogenesis. Therefore, it can be considered as a promising plan for future studies.

Published
2021

3. Antiproliferative Effect of Gaillardin from

Author

Afshin, Karami, Maryam, Hamzeloo-Moghadam, Amir, Yami, Mohieddin, Barzegar, Pargol, Mashati, and Ahmad, Gharehbaghian

Subjects
Lactones, Cell Line, Tumor, Humans, Apoptosis, Inula, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Sesquiterpenes
Abstract

Gaillardin (GLN) is a sesquiterpene lactone isolated from the chloroform extract of

Published
2019

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