1. Visceral adipose tissue is associated with microstructural brain tissue damage
- Author
-
Annette A. van den Berg-Huysmans, Albert de Roos, Diana van Heemst, Ralph L. Widya, Noortje van der Bijl, Mark A. van Buchem, Jeroen van der Grond, Hildo J. Lamb, Lucia J.M. Kroft, Irmhild Altmann-Schneider, and P. Eline Slagboom
- Subjects
Pathology ,medicine.medical_specialty ,Nutrition and Dietetics ,business.industry ,Endocrinology, Diabetes and Metabolism ,Confounding ,Medicine (miscellaneous) ,Adipose tissue ,Brain tissue ,Stepwise regression ,medicine.disease ,White matter ,Endocrinology ,medicine.anatomical_structure ,Diabetes mellitus ,medicine ,Subcutaneous adipose tissue ,Magnetization transfer ,business ,human activities - Abstract
Objective Obesity has been associated with microstructural brain tissue damage. Different fat compartments demonstrate different metabolic and endocrine behaviors. The aim was to investigate the individual associations between abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) and microstructural integrity in the brain. Methods This study comprised 243 subjects aged 65.4 ± 6.7 years. The associations between abdominal VAT and SAT, assessed by CT, and magnetization transfer imaging markers of brain microstructure for gray and white matter were analyzed and adjusted for confounding factors. Results VAT was associated with normalized magnetization transfer ratio (MTR) peak height in gray (β −0.216) and white matter (β −0.240) (both P 0.05). Stepwise linear regression analysis showed that only VAT was associated with normalized MTR peak height in gray and white matter (both P
- Published
- 2015