1. Overweight and obesity are risks factors of severe illness in patients with COVID‐19
- Author
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Songping Huang, Li Zhu, Fang Ji, Haiyan Zhao, Yuxin Chen, Leyang Xue, Zhaoping Zhang, Xinying Guan, Chao Wu, Yang Li, Chuanwu Zhu, Xiang-An Zhao, Huaping Shao, Xiaobing Chen, Tianmin Xu, Jian Wang, Rahma Issa, Yun Zhao, Dawen Sang, Fang Ming, Chunyang Li, Xuebing Yan, Biao Zhang, Juan Cheng, Longgen Liu, Rui Huang, and Jie Wei
- Subjects
Adult ,Male ,medicine.medical_specialty ,obesity ,Endocrinology, Diabetes and Metabolism ,Pneumonia, Viral ,Medicine (miscellaneous) ,030209 endocrinology & metabolism ,Type 2 diabetes ,Overweight ,03 medical and health sciences ,coronavirus disease 2019 ,Betacoronavirus ,0302 clinical medicine ,Endocrinology ,Risk Factors ,Internal medicine ,Diabetes mellitus ,medicine ,Animals ,Humans ,030212 general & internal medicine ,Risk factor ,Pandemics ,Retrospective Studies ,Nutrition and Dietetics ,business.industry ,SARS-CoV-2 ,severe illness ,COVID-19 ,Retrospective cohort study ,Original Articles ,Middle Aged ,medicine.disease ,Obesity ,Pneumonia ,Respiratory failure ,Diabetes Mellitus, Type 2 ,Original Article ,Female ,medicine.symptom ,business ,Coronavirus Infections - Abstract
OBJECTIVE: This study aimed to observe the clinical characteristics of patients with coronavirus disease 2019 (COVID-19) with overweight and obesity. METHODS: Consecutive patients with COVID-19 from 10 hospitals of Jiangsu province, China, were enrolled. RESULTS: A total of 297 patients with COVID-19 were included, and 39.39% and 13.47% of patients had overweight and obesity, respectively. The proportions of bilateral pneumonia (92.50% vs. 73.57%, P = 0.033) and type 2 diabetes (17.50% vs. 3.57%, P = 0.006) were higher in patients with obesity than lean patients. The proportions of severe illness in patients with overweight (12.82% vs. 2.86%, P = 0.006) and obesity (25.00% vs. 2.86%, P < 0.001) were significantly higher than lean patients. More patients with obesity developed respiratory failure (20.00% vs. 2.86%, P < 0.001) and acute respiratory distress syndrome (5.00% vs. 0%, P = 0.024) than lean patients. The median days of hospitalization were longer in patients with obesity than lean patients (17.00 days vs. 14.00 days, P = 0.029). Overweight (OR, 4.222; 95% CI: 1.322-13.476; P = 0.015) and obesity (OR, 9.216; 95% CI: 2.581-32.903; P = 0.001) were independent risk factors of severe illness. Obesity (HR, 6.607; 95% CI: 1.955-22.329; P = 0.002) was an independent risk factor of respiratory failure. CONCLUSIONS: Overweight and obesity were independent risk factors of severe illness in COVID-19 patients. More attention should be paid to these patients.
- Published
- 2020