1. Effect of BMI on the thermogenic response to cold exposure and associated changes in metabolism and browning markers in adult humans
- Author
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Laura Aline Mengel, Bahareh Nemati Moud, Hatti Seidl, Alberto Mesas-Fernández, Claudine Seeliger, Beate Brandl, Thomas Skurk, Christina Holzapfel, Melina Claussnitzer, and Hans Hauner
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Nutrition. Foods and food supply ,TX341-641 ,Nutritional diseases. Deficiency diseases ,RC620-627 - Abstract
Introduction. Brown adipose tissue (BAT) serves to produce heat by non-shivering thermogenesis. Activation of BAT increases energy expenditure and is seen as a putative strategy to treat obesity. There is conflicting data on the capacity for cold induced thermogenesis in individuals with higher BMI. Methods. To investigate the effect of BMI on cold-induced stimulation of energy expenditure, changes in the metabolic profile, and the expression of browning markers in subcutaneous white adipose tissue (scWAT), healthy adults (N=173, 50.9 % females) with a median age of 26.0 [Interquartile range (IQR): 23.0;28.0] years and a median BMI of 23.6 [IQR: 21.9;26.6] kg/m² were exposed to short-term mild cold exposure (CE). Resting energy expenditure (REE) was measured by indirect calorimetry and blood sampling was conducted at baseline and after CE. In a subgroup of participants with obesity, subcutaneous abdominal fat biopsies were taken before and after CE. Results. The cold-induced median increase in REE was 74 (IQR: -28; 241) kcal/day (p
- Published
- 2022
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