1. Superior appetite hormone profile after equivalent weight loss by gastric bypass compared to gastric banding.
- Author
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Bose M, Machineni S, Oliván B, Teixeira J, McGinty JJ, Bawa B, Koshy N, Colarusso A, and Laferrère B
- Subjects
- Adult, Amyloid blood, Amyloid metabolism, Follow-Up Studies, Gastroplasty methods, Ghrelin blood, Ghrelin metabolism, Glucagon-Like Peptide 1 blood, Glucagon-Like Peptide 1 metabolism, Hormones metabolism, Hormones physiology, Humans, Islet Amyloid Polypeptide, Leptin blood, Leptin metabolism, Metabolome physiology, Middle Aged, Peptide YY blood, Peptide YY metabolism, Time Factors, Appetite Regulation physiology, Gastric Bypass rehabilitation, Gastroplasty rehabilitation, Hormones blood, Weight Loss physiology
- Abstract
The goal of this study was to understand the mechanisms of greater weight loss by gastric bypass (GBP) compared to gastric banding (GB) surgery. Obese weight- and age-matched subjects were studied before (T0), after a 12 kg weight loss (T1) by GBP (n = 11) or GB (n = 9), and at 1 year after surgery (T2). peptide YY(3-36) (PYY(3-36)), ghrelin, glucagon-like peptide-1 (GLP-1), leptin, and amylin were measured after an oral glucose challenge. At T1, glucose-stimulated GLP-1 and PYY levels increased significantly after GBP but not GB. Ghrelin levels did not change significantly after either surgery. In spite of equivalent weight loss, leptin and amylin decreased after GBP, but not after GB. At T2, weight loss was greater after GBP than GB (P = 0.003). GLP-1, PYY, and amylin levels did not significantly change from T1 to T2; leptin levels continued to decrease after GBP, but not after GB at T2. Surprisingly, ghrelin area under the curve (AUC) increased 1 year after GBP (P = 0.03). These data show that, at equivalent weight loss, favorable GLP-1 and PYY changes occur after GBP, but not GB, and could explain the difference in weight loss at 1 year. Mechanisms other than weight loss may explain changes of leptin and amylin after GBP.
- Published
- 2010
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