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The biological mechanisms involved in asthma caused by occupational irritants remain poorly understood. Occupational exposure to irritants may be associated to a specific asthma endotype. We aimed to study the associations between occupational exposure to irritants and asthma profiles identified by a cluster analysis integrating clinical characteristics and biomarkers related to oxidative stress and inflammation. We analyzed data from 997 adults from the second phase of the EGEA study (mean age: 45 years, 46% men). Exposure to irritants at the current job was assessed by a new asthma-specific job exposure matrix (http://oasjem.vjf.inserm.fr/), with 3 levels of exposure (no/medium/high). Logistic regression models adjusted for age, sex and smoking were used to study the associations between occupational exposure to irritants and each profile (P). Predominant characteristics of the profiles were: P1 asymptomatic (n=463); P2 respiratory symptoms without asthma (n=167); P3 adult-onset asthma, poor lung function, respiratory symptoms, highest oxidative stress-related biomarker and neutrophil levels (n=50); P4 paucigranulocytic asthma, normal lung function (n=203); P5 childhood-onset asthma, highest IgE level (n=114). In P1, 9% had high exposure to irritants, 10% in P2, 22% in P3, 8% in P4 and 12% in P5. High exposure to irritants was associated with P3 (vs. P1, Odds Ratio (OR) [95%CI]=2.8 [1.2-6.5]). Occupational exposure to irritants was not associated with other profiles (OR range:0.9-1.3). Results suggest that occupational exposure to irritants was related to an asthma endotype characterized by poor lung function, respiratory symptoms, oxidative stress and neutrophilic inflammation.