1. Occupation and renal cell cancer in Central and Eastern Europe
- Author
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Heck, JE, Charbotel, B, Moore, LE, Karami, S, Zaridze, DG, Matveev, V, Janout, V, Kollárová, H, Foretova, L, Bencko, V, Szeszenia-Dabrowska, N, Lissowska, J, Mates, D, Ferro, G, Chow, W-H, Rothman, N, Stewart, P, Brennan, P, and Boffetta, P
- Subjects
Health Services and Systems ,Health Sciences ,Cancer ,Kidney Disease ,Adult ,Aged ,Aged ,80 and over ,Agriculture ,Architecture ,Carcinoma ,Renal Cell ,Case-Control Studies ,Czech Republic ,Engineering ,Female ,Humans ,Kidney Neoplasms ,Male ,Middle Aged ,Occupational Diseases ,Occupations ,Poland ,Risk Factors ,Romania ,Russia ,Sex Factors ,Time Factors ,Clinical Sciences ,Public Health and Health Services ,Other Commerce ,Management ,Tourism and Services ,Environmental & Occupational Health ,Human resources and industrial relations ,Epidemiology ,Public health - Abstract
ObjectiveCentral and Eastern Europe has among the highest rates of renal cell cancer worldwide. Few studies have been conducted in these areas to investigate the possible role of occupational exposures in renal cell cancer aetiology. The purpose of this study was to examine the association of renal cell cancer with employment in specific occupations and industries.MethodsFrom 1999 to 2003, we conducted a hospital-based case-control study in seven areas of the Czech Republic, Poland, Romania and Russia. A detailed occupational history was collected from renal cell cancer cases and controls, together with information on potential confounders. Odds ratios (ORs) and 95% CI of cancer risk were calculated for having ever been employed in selected jobs and industries, with follow-up analyses examining duration of employment.ResultsA total of 992 histologically confirmed incident renal cell cancer cases and 1459 controls were included in the analysis. An increased risk of renal cell cancer was observed for workers in agricultural labour and animal husbandry (OR 1.43; 95% CI 1.05 to 1.93), particularly among women employed as general farm workers (OR 2.73; 95% CI 1.05 to 7.13). Risk gradients for agricultural work increased with longer employment. An overall increased risk of renal cell cancer was seen among architects and engineers (OR 1.89; 95% CI 1.35 to 2.65), and mechanical engineers (OR 1.71; 95% CI 1.03 to 2.84).ConclusionsOur data suggest an association between renal cell cancer and agricultural work, particularly among female workers.
- Published
- 2010