1. MiR-520h-mediated FOXC2 regulation is critical for inhibition of lung cancer progression by resveratrol.
- Author
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Yu, Y-H, Chen, H-A, Chen, P-S, Cheng, Y-J, Hsu, W-H, Chang, Y-W, Chen, Y-H, Jan, Y, Hsiao, M, Chang, T-Y, Liu, Y-H, Jeng, Y-M, Wu, C-H, Huang, M-T, Su, Y-H, Hung, M-C, Chien, M-H, Chen, C-Y, Kuo, M-L, and Su, J-L
- Subjects
GENETIC regulation ,LUNG cancer ,CANCER invasiveness ,RESVERATROL ,HERBAL medicine ,CLINICAL trials ,EPITHELIAL cells ,METASTASIS - Abstract
Resveratrol, a phytochemical found in various plants and Chinese herbs, is associated with multiple tumor-suppressing activities, has been tested in clinical trials. However, the molecular mechanisms involved in resveratrol-mediated tumor suppressing activities are not yet completely defined. Here, we showed that treatment with resveratrol inhibited cell mobility through induction of the mesenchymal-epithelial transition (MET) in lung cancer cells. We also found that downregulation of FOXC2 (forkhead box C2) is critical for resveratrol-mediated suppression of tumor metastasis in an in vitro and in vivo models. We also identified a signal cascade, namely, resveratrol-∣miRNA-520h-∣PP2A/C-∣Akt → NF-κB → FOXC2, in which resveratrol inhibited the expression of FOXC2 through regulation of miRNA-520h-mediated signal cascade. This study identified a new miRNA-520h-related signal cascade involved in resveratrol-mediated tumor suppression activity and provide the clinical significances of miR-520h, PP2A/C and FOXC2 in lung cancer patients. Our results indicated a functional link between resveratrol-mediated miRNA-520h regulation and tumor suppressing ability, and provide a new insight into the role of resveratrol-induced molecular and epigenetic regulations in tumor suppression. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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