Search

Your search keyword '"Galluzzi, Lorenzo"' showing total 2 results
2 results on '"Galluzzi, Lorenzo"'

1. Platinum-based chemotherapy inflames the ovarian carcinoma microenvironment through cellular senescence.

Author

Álvarez-Abril, Beatriz, García-Martínez, Elena, and Galluzzi, Lorenzo

Subjects
*CELLULAR aging, *OVARIAN epithelial cancer, *IMMUNE checkpoint inhibitors, *ANIMAL models for aging, *CANCER chemotherapy, *GENETIC recombination, *CARCINOMA
Abstract

Epithelial ovarian carcinoma (EOC) is virtually insensitive to immune checkpoint inhibitors (ICIs). Recent findings from an innovative mouse model of EOC demonstrate that senescence induction underlies the increased sensitivity of homologous recombination-defective EOCs to platinum-based chemotherapy as it initiates tumor infiltration by immune effector cells coupled to restored sensitivity to ICIs. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

2. A mitochondrial checkpoint to adaptive anticancer immunity.

Author

Kepp, Oliver, Liu, Peng, Kroemer, Guido, and Galluzzi, Lorenzo

Subjects
*MITOCHONDRIA, *IMMUNE checkpoint proteins, *CELL death, *DENDRITIC cells, *IMMUNITY
Abstract

BCL2 robustly preserves mitochondrial integrity, hence inhibiting innate immune signaling and apoptotic cell death in several cell types. Here, we comment on our recent data demonstrating that BCL2 also limits the ability of dendritic cells to elicit adaptive immune responses, lending support to a universal immunosuppressive function for the mitochondrial immune checkpoint. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results