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1. Chemoimmunotherapy targeting Wilms’ tumor 1 (WT1)-specific cytotoxic T lymphocyte and helper T cell responses for patients with pancreatic cancer.

Author

Koido, Shigeo, Homma, Sadamu, Okamoto, Masato, Takakura, Kazuki, Gong, Jianlin, Sugiyama, Haruo, Ohkusa, Toshifumi, and Tajiri, Hisao

Subjects
*PANCREATIC cancer, *T cells, *IMMUNOTHERAPY, *DENDRITIC cells, *EPITOPES, *CANCER chemotherapy
Abstract

We designed a phase 1 study using dendritic cells (DCs) pulsed with a mixture of three types of Wilms’ tumor 1 (WT1) peptides, including MHC class I/II restricted epitopes (DC/WT1-I/II). Our recent work reveals that the combination of DC/WT1-I/II and chemotherapy induced long-term WT1-specific CD4+and CD8+T cell responses. [ABSTRACT FROM AUTHOR]

Published
2014
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