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1. Anticancer activity of cardiac glycosides At the frontier between cell-autonomous and immunological effects.

Author

Kepp, Oliver, Menger, Laurie, Vacchelli, Erika, Adjemian, Sandy, Martins, Isabelle, Yuting Ma, Sukkurwala, Abdul Qader, Michaud, Mickaël, Galluzzi, Lorenzo, Zitvogel, Laurence, and Kroemer, Guido

Subjects
CARDIAC glycosides, CANCER prevention, DIGOXIN, IMMUNE response, CANCER cells, DRUG therapy
Abstract

Retrospective clinical data indicate that cardiac glycosides (CGs), notably digoxin, prolong the survival of carcinoma patients treated with conventional chemotherapy. CGs are known to influence the immune response at multiple levels. In addition, recent results suggest that CGs trigger the immunogenic demise of cancer cells, an effect that most likely contributes to their clinical anticancer activity. [ABSTRACT FROM AUTHOR]

Published
2012
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